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View Structure Prediction Details

Protein: UAF30
Organism: Saccharomyces cerevisiae
Length: 228 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UAF30.

Description E-value Query
Range
Subject
Range
UAF30 - Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription sti...
gi|190407596 - gi|190407596|gb|EDV10863.1| hypothetical protein SCRG_01676 [Saccharomyces cerevisiae RM11-1a]
UAF30_YEAST - Upstream activation factor subunit UAF30 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
2.0E-57 [1..228] [1..228]
SMRD1_MOUSE, SCD... - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Mus...
4.0E-50 [39..224] [205..394]
gi|114644841, gi... - gi|114644841|ref|XP_001155587.1| PREDICTED: SWI/SNF-related matrix-associated actin-dependent regula...
gi|4566530 - gi|4566530|gb|AAD23390.1|AF109733_1 SWI/SNF-related, matrix-associated, actin-dependent regulator of...
gi|109096590 - gi|109096590|ref|XP_001110916.1| PREDICTED: similar to SWI/SNF-related matrix-associated actin-depen...
tr|G3HX65|G3HX65... - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Cri...
5.0E-49 [39..224] [146..335]
gi|195566518, gi... - gi|195566518|ref|XP_002106827.1| GD15903 [Drosophila simulans], gi|194204219|gb|EDX17795.1| GD15903 ...
Bap60-PA - The gene Brahma associated protein 60kD is referred to in FlyBase by the symbol Dmel\Bap60 (CG4303, ...
1.0E-47 [39..224] [211..397]
gi|25405318, gi|... - gi|5430749|gb|AAD43149.1|AC007504_4 Hypothetical Protein [Arabidopsis thaliana], pir||A96532 hypothe...
1.0E-46 [1..223] [1..206]
SMRD2_RAT - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Rat...
5.0E-45 [39..224] [231..413]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-45 [39..224] [231..413]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAELNDYSTM IDILLSDMDL ETVTTKKVRM ALKEVYAIDV ESQGKAINKL IRKHLDLVKE  60
   61 RPRFERSLED LLKENATLAI ELTKEITVSK RSSGEEKND

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.855 0.093 RNA polymerase I transcription factor activity a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.828 0.015 RNA polymerase I transcription factor activity a.46.1 Methionine synthase domain
View Download 0.822 0.015 RNA polymerase I transcription factor activity a.7.6 Ribosomal protein S20
View Download 0.826 N/A N/A a.46.1 Methionine synthase domain
View Download 0.734 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.716 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.708 N/A N/A a.7.7 BAG domain
View Download 0.683 N/A N/A a.118.1 ARM repeat
View Download 0.658 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.645 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.612 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.591 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.586 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.581 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.576 N/A N/A a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.571 N/A N/A a.47.2 t-snare proteins
View Download 0.570 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.565 N/A N/A a.74.1 Cyclin-like
View Download 0.564 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.553 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.542 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.533 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.528 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.514 N/A N/A a.46.1 Methionine synthase domain
View Download 0.503 N/A N/A a.74.1 Cyclin-like
View Download 0.500 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.497 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.494 N/A N/A a.118.14 FliG
View Download 0.489 N/A N/A a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.487 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.484 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.482 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.475 N/A N/A a.29.2 Bromodomain
View Download 0.465 N/A N/A a.7.7 BAG domain
View Download 0.462 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.453 N/A N/A a.118.8 TPR-like
View Download 0.447 N/A N/A c.55.4 Translational machinery components
View Download 0.440 N/A N/A a.24.11 Bacterial GAP domain
View Download 0.437 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.436 N/A N/A a.74.1 Cyclin-like
View Download 0.432 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.431 N/A N/A a.156.1 S13-like H2TH domain
View Download 0.428 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.423 N/A N/A a.24.3 Cytochromes
View Download 0.422 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.417 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.410 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.405 N/A N/A a.118.1 ARM repeat
View Download 0.403 N/A N/A a.118.1 ARM repeat
View Download 0.398 N/A N/A a.29.2 Bromodomain
View Download 0.395 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.382 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.382 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.379 N/A N/A a.23.5 Hemolysin expression modulating protein HHA
View Download 0.373 N/A N/A a.47.2 t-snare proteins
View Download 0.364 N/A N/A a.118.1 ARM repeat
View Download 0.363 N/A N/A a.130.1 Chorismate mutase II
View Download 0.361 N/A N/A a.47.2 t-snare proteins
View Download 0.360 N/A N/A a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.359 N/A N/A a.118.1 ARM repeat
View Download 0.358 N/A N/A a.74.1 Cyclin-like
View Download 0.358 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.356 N/A N/A a.83.1 Guanido kinase N-terminal domain
View Download 0.351 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.350 N/A N/A a.47.2 t-snare proteins
View Download 0.347 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.343 N/A N/A a.118.1 ARM repeat
View Download 0.339 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.339 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.338 N/A N/A a.118.1 ARM repeat
View Download 0.338 N/A N/A a.24.3 Cytochromes
View Download 0.333 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.323 N/A N/A a.39.1 EF-hand
View Download 0.321 N/A N/A a.46.1 Methionine synthase domain
View Download 0.320 N/A N/A a.39.3 Cloroperoxidase
View Download 0.320 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.316 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.314 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.312 N/A N/A a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.312 N/A N/A a.118.1 ARM repeat
View Download 0.304 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.301 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.301 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.301 N/A N/A d.55.1 Ribosomal protein L22
View Download 0.300 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.297 N/A N/A a.46.1 Methionine synthase domain
View Download 0.297 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.297 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.295 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.294 N/A N/A a.4.8 Ribosomal protein S18
View Download 0.291 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.290 N/A N/A a.23.5 Hemolysin expression modulating protein HHA
View Download 0.286 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.285 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.284 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.283 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.276 N/A N/A a.39.3 Cloroperoxidase
View Download 0.274 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.273 N/A N/A a.26.1 4-helical cytokines
View Download 0.272 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.271 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.270 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.265 N/A N/A a.81.1 N-terminal domain of DnaB helicase
View Download 0.262 N/A N/A a.118.8 TPR-like
View Download 0.262 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.259 N/A N/A a.74.1 Cyclin-like
View Download 0.258 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.258 N/A N/A a.4.1 Homeodomain-like
View Download 0.258 N/A N/A a.26.1 4-helical cytokines
View Download 0.257 N/A N/A a.118.8 TPR-like
View Download 0.256 N/A N/A a.74.1 Cyclin-like
View Download 0.256 N/A N/A a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.253 N/A N/A i.1.1 Ribosome and ribosomal fragments
View Download 0.250 N/A N/A b.88.1 Mss4-like
View Download 0.249 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.248 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.248 N/A N/A a.7.1 Spectrin repeat
View Download 0.247 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.246 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.243 N/A N/A a.46.1 Methionine synthase domain
View Download 0.242 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.242 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.237 N/A N/A a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.236 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.234 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.234 N/A N/A a.65.1 Annexin
View Download 0.232 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.232 N/A N/A a.46.1 Methionine synthase domain
View Download 0.231 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.231 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.231 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.229 N/A N/A a.46.1 Methionine synthase domain
View Download 0.229 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.229 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.229 N/A N/A a.118.8 TPR-like
View Download 0.227 N/A N/A a.46.1 Methionine synthase domain
View Download 0.227 N/A N/A a.47.2 t-snare proteins
View Download 0.226 N/A N/A a.3.1 Cytochrome c
View Download 0.226 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.226 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.225 N/A N/A a.118.1 ARM repeat
View Download 0.221 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.220 N/A N/A a.26.1 4-helical cytokines
View Download 0.219 N/A N/A a.26.1 4-helical cytokines
View Download 0.219 N/A N/A d.55.1 Ribosomal protein L22
View Download 0.219 N/A N/A a.74.1 Cyclin-like
View Download 0.218 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.218 N/A N/A a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.218 N/A N/A a.46.1 Methionine synthase domain
View Download 0.214 N/A N/A d.68.3 SirA-like
View Download 0.214 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.211 N/A N/A c.23.1 CheY-like
View Download 0.211 N/A N/A a.4.1 Homeodomain-like
View Download 0.208 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.207 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.207 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.205 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.202 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.201 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.200 N/A N/A a.83.1 Guanido kinase N-terminal domain

Predicted functions:

Term Confidence Notes
binding 2.63842828741542 bayes_pls_golite062009
transcription regulator activity 2.62775554429027 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.953438255689584 bayes_pls_golite062009
histone binding 0.948950535074526 bayes_pls_golite062009
protein binding 0.529408559970229 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.439630834571696 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [100-228]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SETKGTHVEK KKGTVSKSPI STRKVTLSKS LASLLGEHEL TRTEVVRRLW AYIKAHNLQN  60
   61 PNNKKEILCD EKLELILGKS TNMFEMHKIL ASHMTEPKKI SDCPPLIQEV RRKEKPIVSD 120
  121 SEQSDTKGI

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 49.769551
Match: PF02201
Description: SWIB/MDM2 domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.01592136607858 bayes_pls_golite062009
binding 3.20303599400601 bayes_pls_golite062009
basal transcription repressor activity 2.69162769894095 bayes_pls_golite062009
transcription coactivator activity 2.58234407051051 bayes_pls_golite062009
transcription repressor activity 1.98538788872171 bayes_pls_golite062009
transcription activator activity 1.83085389017135 bayes_pls_golite062009
transcription factor binding 1.73032563380905 bayes_pls_golite062009
transcription cofactor activity 1.60414428986898 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.51390743508971 bayes_pls_golite062009
protein binding 1.38134467541454 bayes_pls_golite062009
ligase activity 0.802664465339603 bayes_pls_golite062009
structural molecule activity 0.66106995897056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.15313128037113 bayes_pls_golite062009
catalytic activity 0.121624777548864 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle