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View Structure Prediction Details

Protein: HNT3
Organism: Saccharomyces cerevisiae
Length: 217 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNT3.

Description E-value Query
Range
Subject
Range
APTX_YEAST - Aprataxin-like protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HNT3 PE=1 SV=1
HNT3 - DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucl...
4.0E-77 [1..217] [1..217]
APTX_MACFA - Aprataxin OS=Macaca fascicularis GN=APTX PE=2 SV=1
2.0E-58 [3..206] [181..350]
APTX_SCHPO - Aprataxin-like protein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hnt3 PE=1 SV=1
SPCC18.09c - conserved eukaryotic protein
3.0E-58 [2..211] [33..223]
BH140_ARATH - Transcription factor bHLH140 OS=Arabidopsis thaliana GN=BHLH140 PE=3 SV=1
3.0E-57 [2..206] [715..889]
gi|32527954, gi|... - gi|8923156|ref|NP_060162.1| aprataxin isoform d [Homo sapiens], gi|7020073|dbj|BAA90985.1| unnamed p...
6.0E-52 [11..206] [1..162]
CG5316-PA - This gene is referred to in FlyBase by the symbol Dmel\CG5316 (CG5316, FBgn0038704). It is a protein...
2.0E-34 [1..179] [1..139]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWRYALKNY VTSPETVNDD TVTYFDDKVS IIRDSFPKSE CHLLILPRTM QLSRSHPTKV  60
   61 IDAKFKNEFE SYVNSAIDHI FRHFQEKFRI KKSDDDKDPC WDDILKDKNK FVRNFVQVGI 120
  121 HSVPSMANLH IHVISKDFHS VRLKNKKHYN SFNTGFFISW D

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.62
Match: 1av5A
Description: Protein kinase C inhibitor-1, PKCI-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.15228990656368 bayes_pls_golite062009
nucleic acid binding 0.73265651460534 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.631037396994785 bayes_pls_golite062009
transferase activity 0.405724480958777 bayes_pls_golite062009
catalytic activity 0.128210794769743 bayes_pls_golite062009
protein binding 0.0801073049129787 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [162-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLPLNGKNLG TDKEIETTYL KEHDLLCCYC QRNFSNKFSL LKKHLELEFN SHFELK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.439 a.60.1 SAM/Pointed domain
View Download 0.420 a.144.2 Ribosomal protein L20
View Download 0.570 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.348 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.336 a.4.5 "Winged helix" DNA-binding domain
View Download 0.303 a.5.2 UBA-like
View Download 0.285 d.58.1 4Fe-4S ferredoxins
View Download 0.247 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.242 d.42.1 POZ domain
View Download 0.234 a.4.10 N-terminal Zn binding domain of HIV integrase
View Download 0.222 a.60.1 SAM/Pointed domain
View Download 0.221 a.4.10 N-terminal Zn binding domain of HIV integrase
View Download 0.206 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle