YRC Public Data Repository - Protein Structure Prediction

Protein:	NPT1
Organism:	Saccharomyces cerevisiae
Length:	429 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPT1.

Description	E-value	Query Range	Subject Range
gi\|207341031 - gi\|207341031\|gb\|EDZ69202.1\| YOR209Cp-like protein [Saccharomyces cerevisiae AWRI1631] NPT1 - Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for... NPT1_YEAST - Nicotinate phosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPT...	0.0	[1..429]	[1..429]
gi\|107100040 - gi\|107100040\|ref\|ZP_01363958.1\| hypothetical protein PaerPA_01001061 [Pseudomonas aeruginosa PACS2] gi\|254238961, gi... - gi\|84316914\|ref\|ZP_00965372.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Pseudomonas aerugi... gi\|254244814, gi... - gi\|84323093\|ref\|ZP_00971170.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Pseudomonas aerugi... gi\|218773695, gi... - gi\|218893467\|ref\|YP_002442336.1\| nicotinate phosphoribosyltransferase [Pseudomonas aeruginosa LESB58... PNB2_PSEAE, PNCB... - Nicotinate phosphoribosyltransferase 2 OS=Pseudomonas aeruginosa GN=pncB2 PE=1 SV=1, (Q9HW26) Nicoti... gi\|32039590, gi\|... - gi\|32039590\|ref\|ZP_00137862.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Pseudomonas aerugi... PNCB2_PSEAE - Nicotinate phosphoribosyltransferase 2 OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PR...	0.0	[2..412]	[7..395]
PNCB_ECOBW - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=pncB PE=3... PNCB_ECOLI - Nicotinate phosphoribosyltransferase (EC 2.4.2.11) (NAPRTase) - Escherichia coli gi\|1651456, gi\|8... - gi\|89107781\|ref\|AP_001561.1\| nicotinate phosphoribosyltransferase [Escherichia coli str. K-12 substr... EG10742 - nicotinate phosphoribosyltransferase / Nicotinate phosphoribosyltransferase EG10742 - nicotinate phosphoribosyltransferase / Nicotinate phosphoribosyltransferase PNCB_ECODH - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain K12 / DH10B) GN=pncB PE=3 SV=1	0.0	[2..417]	[5..398]
gi\|208822263, gi... - gi\|208822263\|ref\|ZP_03262582.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. ... gi\|254792131, gi... - gi\|254792131\|ref\|YP_003076968.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str.... PNCB_ECO5E - Nicotinate phosphoribosyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=pncB PE=3... gi\|217322744, gi... - gi\|217326523\|ref\|ZP_03442607.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. ... gi\|189375324, gi... - gi\|189375324\|gb\|EDU93740.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC50... gi\|195939654 - gi\|195939654\|ref\|ZP_03085036.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. ... gi\|209774692, gi... - pir\|\|D85619 nicotinate phosphoribosyltransferase [imported] - Escherichia coli (strain O157:H7, subs... gi\|208727551, gi... - gi\|208807750\|ref\|ZP_03250087.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. ... gi\|13360473, gi\|... - gi\|15830268\|ref\|NP_309041.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. Sak... gi\|208731983, gi... - gi\|208815335\|ref\|ZP_03256514.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. ... gi\|15800792, gi\|... - gi\|15800792\|ref\|NP_286806.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 EDL933],... gi\|168769929, gi... - gi\|189361162\|gb\|EDU79581.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC44... PNCB_ECO57 - Nicotinate phosphoribosyltransferase OS=Escherichia coli O157:H7 GN=pncB PE=3 SV=3 gi\|187768382, gi... - gi\|187768382\|gb\|EDU32226.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC41... gi\|188998777, gi... - gi\|188998777\|gb\|EDU67763.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC40... gi\|189372693, gi... - gi\|189372693\|gb\|EDU91109.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC86... gi\|168751197, gi... - gi\|188014732\|gb\|EDU52854.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC41... gi\|189355902, gi... - gi\|189355902\|gb\|EDU74321.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC44... gi\|189366793, gi... - gi\|189366793\|gb\|EDU85209.1\| nicotinate phosphoribosyltransferase [Escherichia coli O157:H7 str. EC45...	0.0	[2..417]	[5..398]
lcl\|NC_016856.1_... - [gene=pncB] [protein=nicotinate phosphoribosyltransferase] [protein_id=YP_005236729.1] [location=com... gi\|197263805, gi... - gi\|197263805\|ref\|ZP_03163879.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... PNCB_SALTY - Nicotinate phosphoribosyltransferase OS=Salmonella typhimurium GN=pncB PE=3 SV=2 PNCB_SALTY - Nicotinate phosphoribosyltransferase OS=Salmonella typhimurium GN=pncB PE=3 SV=2 PNCB_SALTY - Nicotinate phosphoribosyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)...	0.0	[2..412]	[5..391]
gi\|213418672 - gi\|213418672\|ref\|ZP_03351738.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... gi\|213424617 - gi\|213424617\|ref\|ZP_03357400.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... gi\|213612498 - gi\|213612498\|ref\|ZP_03370324.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... gi\|213999482 - gi\|213999482\|ref\|ZP_03410217.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... PNCB_SALTI - Nicotinate phosphoribosyltransferase OS=Salmonella typhi GN=pncB PE=3 SV=3 gi\|213161884 - gi\|213161884\|ref\|ZP_03347594.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. ent... gi\|16759872 - gi\|16759872\|ref\|NP_455489.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. enteri... PNCB_SALTI - Nicotinate phosphoribosyltransferase OS=Salmonella typhi GN=pncB PE=3 SV=3 gi\|29142355, gi\|... - gi\|29142355\|ref\|NP_805697.1\| nicotinate phosphoribosyltransferase [Salmonella enterica subsp. enteri...	0.0	[2..412]	[5..391]
gi\|229895867, gi... - gi\|229895867\|ref\|ZP_04511037.1\| nicotinate phosphoribosyltransferase [Yersinia pestis Pestoides A], ... gi\|229678898, gi... - gi\|229903128\|ref\|ZP_04518241.1\| nicotinate phosphoribosyltransferase [Yersinia pestis Nepal516], gi\|... gi\|229841387, gi... - gi\|229841387\|ref\|ZP_04461546.1\| nicotinate phosphoribosyltransferase [Yersinia pestis biovar Orienta... gi\|229843492, gi... - gi\|229843492\|ref\|ZP_04463638.1\| nicotinate phosphoribosyltransferase [Yersinia pestis biovar Orienta... PNCB_YERPE - Nicotinate phosphoribosyltransferase OS=Yersinia pestis GN=pncB PE=1 SV=1 PNCB_YERP3 - Nicotinate phosphoribosyltransferase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) ... PNCB_YERPS - Nicotinate phosphoribosyltransferase OS=Yersinia pseudotuberculosis GN=pncB PE=3 SV=1 gi\|149366670, gi... - gi\|149366670\|ref\|ZP_01888704.1\| putative nicotinate phosphoribosyltransferase [Yersinia pestis CA88-... PNCB_YERPS - Nicotinate phosphoribosyltransferase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=p... gi\|15979462, gi\|... - gi\|218928561\|ref\|YP_002346436.1\| nicotinate phosphoribosyltransferase [Yersinia pestis CO92], gi\|161...	0.0	[2..412]	[5..392]
PNCB_XYLFA - Nicotinate phosphoribosyltransferase OS=Xylella fastidiosa GN=pncB PE=3 SV=1 PNCB_XYLFA - Nicotinate phosphoribosyltransferase OS=Xylella fastidiosa (strain 9a5c) GN=pncB PE=3 SV=1	0.0	[3..413]	[2..389]

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Predicted Domain #1

Region A:
Residues: [1-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPVIKSLL DTDMYKITMH AAVFTNFPDV TVTYKYTNRS SQLTFNKEAI NWLKEQFSYL  60
   61 GNLRFTEEEI EYLKQEIPYL PSAYIKYISS SNYKLHPEEQ ISFTSEEIEG KPTHYKLKIL 120
  121 VSGSWKDTIL YEIPLLSLIS EAYFKFVDID WDYENQLEQA EKKAETLFDN GIRFSEFGTR 180
  181 RRR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
nicotinate phosphoribosyltransferase activity	5.75487746784842	bayes_pls_golite062009
nicotinate-nucleotide diphosphorylase (carboxylating) activity	2.03818648292717	bayes_pls_golite062009
binding	1.73051405037757	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	1.28938930256604	bayes_pls_golite062009
catalytic activity	0.60409960326459	bayes_pls_golite062009
protein binding	0.294646489785198	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [184-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLKAQDLIMQ GIMKAVNGNP DRNKSLLLGT SNILFAKKYG VKPIGTVAHE WVMGVASISE  60
   61 DYLHANKNAM DCWINTFGAK NAGLALTDTF GTDDFLKSFR PPYSDAYVGV RQDSGDPVEY 120
  121 TKKISHHYHD VLKLPKFSKI ICYSDSLNVE KAITYSHAAK ENGMLATFGI GTNFTNDFRK 180
  181 KSEPQVKSEP LNIVIKLLEV NGNHAIKISD NLGKNMGDPA TVKRVKEELG YTERSWSGDN 240
  241 EAHRWT