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View Structure Prediction Details

Protein: HIS3
Organism: Saccharomyces cerevisiae
Length: 220 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS3.

Description E-value Query
Range
Subject
Range
gi|39754102 - gi|39754102|gb|AAR30559.1| His3 [Cloning vector pTARBAC2.1]
gi|5853045 - gi|5853045|gb|AAD54288.1| HIS3 protein [Cloning vector pRS4213]
gi|23506930 - gi|23506930|gb|AAN31949.1| imidazoleglycerol-phosphate dehydratase; His3p [Cloning vector YDp-H]
gi|207341048 - gi|207341048|gb|EDZ69214.1| YOR202Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|39754098 - gi|39754098|gb|AAR30556.1| His3 [Cloning vector pTARBAC1.3]
gi|224155855, gi... - gi|224155855|ref|XP_002337643.1| predicted protein [Populus trichocarpa], gi|222869493|gb|EEF06624.1...
gi|63259111 - gi|63259111|gb|AAY40259.1| HIS3 [Cloning vector pHR307a]
HIS7_YEAST - Imidazoleglycerol-phosphate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
gi|151945293 - gi|151945293|gb|EDN63536.1| imidazoleglycerol-phosphate dehydratase [Saccharomyces cerevisiae YJM789...
HIS3 - Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutatio...
gi|94963137 - gi|94963137|gb|ABF48726.1| HIS3 [HIS3/URA3 reporter vector pH3U3]
gi|89954460 - gi|89954460|gb|ABD83652.1| imidazoleglycerolphosphate dehydratase [synthetic construct]
gi|118200046 - gi|118200046|gb|ABK79084.1| HIS3 [Cloning vector pTARBAC6]
1.0E-96 [1..220] [1..220]
gi|13591410 - gi|13591410|gb|AAK29770.1| His3 [YTT vector B]
gi|13591413 - gi|13591413|gb|AAK29772.1| His3 [YTT vector C]
HIS7_LACK1 - Imidazoleglycerol-phosphate dehydratase OS=Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 2...
gi|13591416 - gi|13591416|gb|AAK29774.1| His3 [YTT vector D]
HIS7_LACKL, HIS7... - Imidazoleglycerol-phosphate dehydratase OS=Saccharomyces kluyveri GN=HIS3 PE=3 SV=1, Imidazoleglycer...
8.0E-95 [3..220] [15..232]
HIS7_ZYGRO - Imidazoleglycerol-phosphate dehydratase OS=Zygosaccharomyces rouxii GN=HIS3 PE=3 SV=1
7.0E-93 [3..220] [7..226]
HIS7_ZYGBA - Imidazoleglycerol-phosphate dehydratase OS=Zygosaccharomyces bailii GN=HIS3 PE=2 SV=1
2.0E-92 [3..220] [4..223]
HIS7_CYBJA - Imidazoleglycerol-phosphate dehydratase OS=Cyberlindnera jadinii GN=HIS3 PE=3 SV=1
6.0E-90 [2..219] [8..223]
HIS7_PICST - Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD) - Pichia stipitis (Yeast)
2.0E-89 [4..219] [3..221]
HIS7_CANAX - Imidazoleglycerol-phosphate dehydratase OS=Candida albicans GN=HIS3 PE=3 SV=1
2.0E-88 [4..219] [3..221]
jgi|Picpa1|39082... - null
HIS7_PICPA - Imidazoleglycerol-phosphate dehydratase OS=Komagataella pastoris GN=HIS3 PE=3 SV=1
gi|238032819, gi... - gi|254571823|ref|XP_002493021.1| Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step i...
2.0E-87 [4..219] [7..223]
HIS7_NEUCR - Imidazoleglycerol-phosphate dehydratase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 7...
HIS7_NEUCR - Imidazoleglycerol-phosphate dehydratase OS=Neurospora crassa GN=65E11.030 PE=3 SV=1
4.0E-86 [2..219] [7..227]

Back

Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEQKALVKR ITNETKIQIA ISLKGGPLAI EHSIFPEKEA EAVAEQATQS QVINVHTGIG  60
   61 FLDHMIHALA KHSGWSLIVE CIGDLHIDDH HTTEDCGIAL GQAFKEALGA VRGVKRFGSG 120
  121 FAPLDEALSR AVVDLSNRPY AVVELGLQRE KVGDLSCEMI PHFLESFAEA SRITLHVDCL 180
  181 RGKNDHHRSE SAFKALAVAI REATSPNGTN DVPSTKGVLM 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 109.508638
Match: PF00475
Description: Imidazoleglycerol-phosphate dehydratase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
imidazoleglycerol-phosphate dehydratase activity 1.6337728630325 bayes_pls_golite062009
catalytic activity 0.878454819018611 bayes_pls_golite062009
nucleic acid binding 0.369771518688522 bayes_pls_golite062009
structural constituent of ribosome 0.325699575011026 bayes_pls_golite062009
transcription regulator activity 0.212099606954236 bayes_pls_golite062009
structural molecule activity 2.19428886088058E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle