YRC Public Data Repository - Protein Structure Prediction

Protein:	TOA1
Organism:	Saccharomyces cerevisiae
Length:	286 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOA1.

Description	E-value	Query Range	Subject Range
gi\|8778565, gi\|2... - gi\|8778565\|gb\|AAF79573.1\|AC022464_31 F22G5.18 [Arabidopsis thaliana], pir\|\|D86209 protein F22G5.18 [...	3.0E-91	[2..279]	[3..390]
gi\|151945287 - gi\|151945287\|gb\|EDN63530.1\| transcription factor IIA subunit alpha [Saccharomyces cerevisiae YJM789] TOA1_YEAST - Transcription initiation factor IIA large subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / ... TOA1 - TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator... gi\|207341051 - gi\|207341051\|gb\|EDZ69216.1\| YOR194Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407510 - gi\|190407510\|gb\|EDV10777.1\| transcription initiation factor IIA large chain [Saccharomyces cerevisia...	2.0E-82	[1..286]	[1..286]
TOA1_SCHPO - Transcription initiation factor IIA large subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24... SPBC28F2.09 - transcription factor TFIIA complex large subunit	2.0E-78	[1..286]	[1..369]
gi\|12313737, gi\|... - gi\|12963759\|ref\|NP_076119.1\| general transcription factor IIA, 1-like [Mus musculus], gi\|12313737\|gb...	1.0E-46	[146..285]	[315..468]
gi\|123996161, gi... - gi\|123996161\|gb\|ABM85682.1\| TFIIA-alpha/beta-like factor [synthetic construct], gi\|123981326\|gb\|ABM8... gi\|19684124, gi\|... - gi\|26787968\|ref\|NP_006863.2\| general transcription factor IIA, 1-like isoform 1 [Homo sapiens], gi\|1...	1.0E-44	[140..285]	[319..478]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNAEASRVY EIIVESVVNE VREDFENAGI DEQTLQDLKN IWQKKLTETK VTTFSWDNQF  60
   61 NEGNINGVQN DLNFNLATPG VNSSEFNI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	181.38764
Match:	1ytfB_
Description:	Large chain TOA1, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [89-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEENTGNEGL ILPNINSNNN IPHSGETNIN TNTVEATNNS GATLNTNTSG NTNADVTSQP  60
   61 KIEVKPEIEL TINNANITTV ENIDDESEKK DDEEKEEDVE KTRKEKEQIE QVKLQAKKEK 120
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [210-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SALLDTDEVG SELDDSDDDY LISEGEEDGP DENLMLCLYD KVTRTKARWK CSLKDGVVTI  60
   61 NRNDYTFQKA QVEAEWV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	370.68867
Match:	1ytfC_
Description:	Large chain TOA1, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits