YRC Public Data Repository - Protein Structure Prediction

Protein:	TOA1
Organism:	Saccharomyces cerevisiae
Length:	286 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOA1.

Description	E-value	Query Range	Subject Range
gi\|8778565, gi\|2... - gi\|8778565\|gb\|AAF79573.1\|AC022464_31 F22G5.18 [Arabidopsis thaliana], pir\|\|D86209 protein F22G5.18 [...	3.0E-91	[2..279]	[3..390]
gi\|151945287 - gi\|151945287\|gb\|EDN63530.1\| transcription factor IIA subunit alpha [Saccharomyces cerevisiae YJM789] TOA1_YEAST - Transcription initiation factor IIA large subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / ... TOA1 - TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator... gi\|207341051 - gi\|207341051\|gb\|EDZ69216.1\| YOR194Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407510 - gi\|190407510\|gb\|EDV10777.1\| transcription initiation factor IIA large chain [Saccharomyces cerevisia...	2.0E-82	[1..286]	[1..286]
TOA1_SCHPO - Transcription initiation factor IIA large subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24... SPBC28F2.09 - transcription factor TFIIA complex large subunit	2.0E-78	[1..286]	[1..369]
gi\|12313737, gi\|... - gi\|12963759\|ref\|NP_076119.1\| general transcription factor IIA, 1-like [Mus musculus], gi\|12313737\|gb...	1.0E-46	[146..285]	[315..468]
gi\|123996161, gi... - gi\|123996161\|gb\|ABM85682.1\| TFIIA-alpha/beta-like factor [synthetic construct], gi\|123981326\|gb\|ABM8... gi\|19684124, gi\|... - gi\|26787968\|ref\|NP_006863.2\| general transcription factor IIA, 1-like isoform 1 [Homo sapiens], gi\|1...	1.0E-44	[140..285]	[319..478]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNAEASRVY EIIVESVVNE VREDFENAGI DEQTLQDLKN IWQKKLTETK VTTFSWDNQF  60
   61 NEGNINGVQN DLNFNLATPG VNSSEFNI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	181.38764
Match:	1ytfB_
Description:	Large chain TOA1, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [89-209]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEENTGNEGL ILPNINSNNN IPHSGETNIN TNTVEATNNS GATLNTNTSG NTNADVTSQP  60
   61 KIEVKPEIEL TINNANITTV ENIDDESEKK DDEEKEEDVE KTRKEKEQIE QVKLQAKKEK 120
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.242	b.1.5	Transglutaminase, two C-terminal domains

Predicted Domain #3

Region A:
Residues: [210-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SALLDTDEVG SELDDSDDDY LISEGEEDGP DENLMLCLYD KVTRTKARWK CSLKDGVVTI  60
   61 NRNDYTFQKA QVEAEWV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	370.68867
Match:	1ytfC_
Description:	Large chain TOA1, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits