YRC Public Data Repository - Protein Structure Prediction

Protein:	LPX1
Organism:	Saccharomyces cerevisiae
Length:	387 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LPX1.

Description	E-value	Query Range	Subject Range
LPX1_YEAST - Peroxisomal membrane protein LPX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LPX1 P... LPX1 - Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p alon...	2.0E-83	[1..387]	[1..387]
HYES_RAT - Bifunctional epoxide hydrolase 2 OS=Rattus norvegicus GN=Ephx2 PE=1 SV=1	3.0E-53	[7..342]	[210..542]
HYES_MOUSE - Bifunctional epoxide hydrolase 2 OS=Mus musculus GN=Ephx2 PE=1 SV=2	1.0E-52	[7..342]	[210..542]
gi\|10197684 - gi\|10197684\|gb\|AAG14968.1\|AF233336_1 soluble epoxide hydrolase [Homo sapiens]	3.0E-51	[20..349]	[226..551]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	7.0E-49	[7..342]	[210..541]
gi\|25533254 - pir\|\|AF2333 hypothetical protein all4221 [imported] - Nostoc sp. (strain PCC 7120) gi\|17231713, gi\|... - gi\|17231713\|ref\|NP_488261.1\| hypothetical protein all4221 [Nostoc sp. PCC 7120], gi\|17133356\|dbj\|BAB...	3.0E-46	[34..341]	[10..285]
gi\|15230018, gi\|... - gi\|6714450\|gb\|AAF26137.1\|AC011620_13 putative epoxide hydrolase [Arabidopsis thaliana], gi\|21436463\|...	2.0E-44	[34..344]	[6..324]

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Predicted Domain #1

Region A:
Residues: [1-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQNRFKKET KTCSASWPRA PQSTLCATDR LELTYDVYTS AERQRRSRTA TRLNLVFLHG  60
   61 SGMSKVVWEY YLPRLVAADA EGNYAIDKVL LIDQVNHGDS AVRNRGRLGT NFNWIDGARD 120
  121 VLKIATCELG SIDSHPALNV VIGHSMGGFQ ALACDVLQPN LFHLLILIEP VVITRKAIGA 180
  181 GRPGLPPDSP QIPENLYNSL RLKTCDHFAN ESEYVKYMRN GSFFTNAHSQ ILQNIIDFER 240
  241 TKASGDDEDG GPVRTKMEQA QNLLCYMNMQ TFAPFLISNV KFVRKRTIHI VGARSNWCPP 300
  301 QNQLFLQKTL QNYHLDVIPG GSHLVNVEAP DLVIERINHH IHEFVLTSPL QSSHIPQLTL 360
  361 EERAVMFDRA FDSFKNEALV KTTKQKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.39794
Match:	1cqzA_
Description:	Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.08737094589901	bayes_pls_golite062009
catalytic activity	0.853693238072967	bayes_pls_golite062009
binding	0.401633301499824	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.0490144635545247	bayes_pls_golite062009
protein binding	0.0473186402188429	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: