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View Structure Prediction Details

Protein: DIA2
Organism: Saccharomyces cerevisiae
Length: 746 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DIA2.

Description E-value Query
Range
Subject
Range
DIA2 - Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays...
0.0 [1..746] [1..746]
gi|13277819 - gi|13277819|gb|AAH03794.1| Stress-induced phosphoprotein 1 [Mus musculus]
8.0E-4 [36..208] [367..513]
STIP1_RAT - Stress-induced-phosphoprotein 1 OS=Rattus norvegicus GN=Stip1 PE=1 SV=1
8.0E-4 [36..208] [367..513]
STIP1_CRIGR - Stress-induced-phosphoprotein 1 OS=Cricetulus griseus GN=STIP1 PE=2 SV=1
0.001 [36..208] [367..513]
FBL8_ARATH - Putative F-box/LRR-repeat protein 8 OS=Arabidopsis thaliana GN=FBL8 PE=3 SV=1
0.001 [164..251] [10..104]
gi|61356797, gi|... - gi|61356797|gb|AAX41286.1| stress-induced-phosphoprotein 1 [synthetic construct], gi|61356792|gb|AAX...
STIP1 - stress-induced-phosphoprotein 1
gi|114638257 - gi|114638257|ref|XP_508521.2| PREDICTED: stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing pro...
0.002 [36..208] [367..513]
sti-1 - status:Confirmed UniProt:O16259 protein_id:AAG24172.1
0.005 [36..206] [147..288]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKFITKNK KYTPMSSPGN SGVAIDSTVL KAIELGTRLF KSGEYLQAKR IFTNALRVCD  60
   61 SYSQEQIMRI RNAYQLDTAR PDNKRLYHPR YIKILDNICA CYEKLNDLKS CLDVSQRLLK 120
  121 LEPGNIKCYI RCTRTLIKLK DWKRAYKTCS RGLQLCNNDS NHLRQQKQFI KNNMVQKQDG 180
  181 KRSYIDPLEE TKIAKKKKNN NVLESLPKKK IKGST

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.61
Match: 1qqeA
Description: Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.838457647933563 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 0.788209490718562 bayes_pls_golite062009
cis-trans isomerase activity 0.728844238348547 bayes_pls_golite062009
binding 0.436537606536136 bayes_pls_golite062009
transcription regulator activity 0.238548113422564 bayes_pls_golite062009
protein binding 0.218634943775696 bayes_pls_golite062009
protein kinase activity 0.0817192853858701 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0284131677759829 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [216-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKTDLVGNLP IEILPIIFQR FTTKELVTLS LVCNKWRDKI LYHLDCFQEF N

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 3.05061
Match: PF00646
Description: F-box domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [267-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPINFKNFV KFMDFLQQNF TRTYRKYILS QVKVSSRITS EELRITQLLF SKMPKCINIE  60
   61 RLILSMPTLT TTQIFKLMVR GGTDFFTRLL ELSLMITYRP DKQHELEILQ TCPLLKKIEL 120
  121 IFVNSLVPIF DGNNSVGRDG SFNVMARHTN MQISTADNDE QGIVEEKVIY SELEKITLIC 180
  181 DKKKIKNFPL CRALLRGQFP LLQKLTITGV TFPMNNQDIM NFQWLLNFPD LKELWIEDND 240
  241 NCELSKFLQL LKFSNVWKNL EKLTFRENKL YPIVNLDEDQ PVTNDDEVPS MLFYKENLQN 300
  301 LEKLDLMGTS ISGSALTRLC EQEYLDGRKL RSLNIGNCPN IQFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [611-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNHAHTARMI LDVNAVLKRL SKLEEINLSH LSSLNDSTMK SFIINVPFLE NLKRLDISHN  60
   61 FEITGISIYE FLKKFQMDHD NEAGGQPLAY LNIDGCSQVS HITVNMIRAQ NLVTQVDCVY 120
  121 ERDVWRKFGI NSYSYS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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