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View Structure Prediction Details

Protein: CDC21
Organism: Saccharomyces cerevisiae
Length: 259 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC21.

Description E-value Query
Range		 Subject
Range
TYSY_YEAST - Thymidylate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC21 PE=1 SV=1
gi|190407409 - gi|190407409|gb|EDV10676.1| thymidylate synthase [Saccharomyces cerevisiae RM11-1a]
CDC21 - Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expressi...
 0.0 [1..259] [1..304]
DRTS2_ARATH - Bifunctional dihydrofolate reductase-thymidylate synthase 2 OS=Arabidopsis thaliana GN=THY-2 PE=2 SV...
 0.0 [3..259] [275..565]
TYSY_MOUSE - Thymidylate synthase OS=Mus musculus GN=Tyms PE=1 SV=1
 0.0 [6..259] [20..307]
gi|15988342, gi|... - gi|15988345|pdb|1JUJ|D Chain D, Human Thymidylate Synthase Bound To Dump And Ly231514, A Pyrrolo(2,3...
 0.0 [8..259] [28..313]
gi|61371785, gi|... - gi|61371791|gb|AAX43731.1| thymidylate synthetase [synthetic construct], gi|61371785|gb|AAX43730.1| ...
 0.0 [8..259] [28..313]
TYSY_RAT - Thymidylate synthase OS=Rattus norvegicus GN=Tyms PE=1 SV=1
 0.0 [3..259] [17..307]

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Predicted Domain #1
Region A:
Residues: [1-259] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMDGKNKEE EQYLDLCKRI IDEGEFRPDR TGTDANLLSE QGVKIWDGNG SREYLDKMGF  60
   61 KDRKVGDLGP VYGFQWRHFG AKYKTCDDDY TGQGIDQLKQ VIHKLKTNPY DRRIIMSAWN 120
  121 PADFDKMALP PCHIFSQFYV SFPKEGEGSG KPRLSCLLYQ RSCDMGLGVP FNIASYALLT 180
  181 RMIAKVVDME PGEFIHTLGD AHVYKDHIDA LKEQITRNPR PFPKLKIKRD VKDIDDFKLT 240
  241 DFEIEDYNPH PRIQMKMSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.0
Match: 1ju6A_
Description: Thymidylate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
5,10-methylenetetrahydrofolate-dependent methyltransferase activity 6.29181090719132 bayes_pls_golite062009
thymidylate synthase activity 6.13538715987923 bayes_pls_golite062009
catalytic activity 1.73427871128495 bayes_pls_golite062009
binding 1.29787993009039 bayes_pls_golite062009
transferase activity 1.02276089025842 bayes_pls_golite062009
methyltransferase activity 0.927096828883487 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.91282507161672 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle