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View Structure Prediction Details

Protein: NOP8
Organism: Saccharomyces cerevisiae
Length: 484 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOP8.

Description E-value Query
Range
Subject
Range
NOP8 - Nucleolar protein required for 60S ribosomal subunit biogenesis
NOP8_YEAST - 60S ribosome subunit biogenesis protein NOP8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
0.0 [1..484] [1..484]
SPBP16F5.06 - ribosome biogenesis protein Nop6
YNW6_SCHPO - Uncharacterized RNA-binding protein P16F5.06 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
0.0 [5..479] [3..473]
gi|19347816 - gi|19347816|gb|AAL86321.1| putative poly(A)-binding protein [Arabidopsis thaliana]
3.0E-34 [8..145] [200..342]
gi|12853154 - gi|12853154|dbj|BAB29660.1| unnamed protein product [Mus musculus]
3.0E-28 [2..122] [21..142]
gi|7022076 - gi|7022076|dbj|BAA91479.1| unnamed protein product [Homo sapiens]
3.0E-28 [7..122] [8..124]
gi|7673355 - gi|7673355|gb|AAF66823.1|AF190655_1 poly(A)-binding protein [Nicotiana tabacum]
5.0E-25 [8..154] [207..358]
gi|7528270 - gi|7528270|gb|AAF63202.1|AF240679_1 poly(A)-binding protein [Cucumis sativus]
7.0E-25 [8..145] [209..351]
gi|13560783 - gi|13560783|gb|AAK30205.1|AF349964_1 poly(A)-binding protein [Daucus carota]
6.0E-23 [2..145] [210..362]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSVIQKRIF VGNIFHNADD CYSELLDRFG KFGDCQDFQF EKHNHFAFID IRFNDEADFN  60
   61 KLRKSFNNVK FKGNILKVDE AKPNWESTWA VQHAKDLKED IILNAKMKKK NWQHYKKMEN 120
  121 VAKSWKDHKE VIAGRMREAP RKRSQLRNIT FRINV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1b7fA_
Description: Sex-lethal protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.72964573417386 bayes_pls_golite062009
binding 3.0101982407193 bayes_pls_golite062009
nucleic acid binding 2.34356093608328 bayes_pls_golite062009
1.46562488829931 bayes_pls_golite062009
structural molecule activity 1.10982714865204 bayes_pls_golite062009
protein binding 0.89093640300829 bayes_pls_golite062009
mRNA binding 0.554135435832456 bayes_pls_golite062009
ribosomal large subunit binding 0.13509933485234 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [156-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGSLKVYKCY KTKLWGYERN KELNDLVYKF TNNFWKNGYN HIVDRLDYSR AVKTVRFKNG  60
   61 LKQLTVSKDE NVCSGEMDSD ENMSEEEKEK NNVILNDLLK DFDFDKPMTL NDSDEELLTE 120
  121 QRKGEEEEEE EEEKEVNAPE YENVNKTKDQ STLPQEKPEE RKEQDEGDGQ EDNEFIPTFT 180
  181 KEIGQGTISN TETLRNLFNP NEAEPVSQFK LIEDSDNDID HAKDVDVNQL EEEVSKSSDT 240
  241 LGLTSAPVPH VSRDKDNKNF LFFPHLQSPF LVGQTQLSKV RAPGRETMLS NWDEEFWANR 300
  301 GNWTRDMRRK MKDALKHRKR KQSKSGLLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [328-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEFIPTFTKE IGQGTISNTE TLRNLFNPNE AEPVSQFKLI EDSDNDIDHA KDVDVNQLEE  60
   61 EV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [390-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKSSDTLGLT SAPVPHVSRD KDNKNFLFFP HLQSPFLVGQ TQLSKVRAPG RETMLSNWDE  60
   61 EFWANRGNWT RDMRRKMKDA LKHRKRKQSK SGLLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle