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View Structure Prediction Details

Protein: BRX1
Organism: Saccharomyces cerevisiae
Length: 291 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRX1.

Description E-value Query
Range
Subject
Range
BRX1 - Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA pr...
3.0E-81 [1..291] [1..291]
brx1 - ribosome biogenesis protein Brx1
BRX1_SCHPO - Ribosome biogenesis protein brx1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=brx1 PE=3...
5.0E-75 [1..286] [1..292]
gi|16648689, gi|... - gi|23505881|gb|AAN28800.1| At3g15460/MJK13_12 [Arabidopsis thaliana], gi|16648689|gb|AAL25537.1| AT3...
1.0E-74 [10..286] [32..310]
BRX1_XENLA - Ribosome biogenesis protein BRX1 homolog OS=Xenopus laevis GN=brix1 PE=2 SV=1
2.0E-72 [3..284] [2..296]
gi|85082716 - gi|85082716|ref|XP_956973.1| hypothetical protein [Neurospora crassa OR74A]
gi|28918055, gi|... - gi|32414967|ref|XP_327963.1| hypothetical protein [Neurospora crassa], gi|28918055|gb|EAA27737.1| hy...
2.0E-69 [1..290] [1..324]
BXDC2_MOUSE, BRI... - (Q9DCA5) Brix domain-containing protein 2 (Ribosome biogenesis protein Brix), (Q9DCA5) Ribosome biog...
6.0E-66 [49..286] [1..228]
CE00268 - status:Confirmed UniProt:P34524 protein_id:AAA28097.1
1.0E-63 [2..286] [34..315]

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Predicted Domain #1
Region A:
Residues: [1-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSIYKALAG KSKDNKSEKK QGNVKQFMNK QRTLLISSRG VNYRHRHLIQ DLSGLLPHSR  60
   61 KEPKLDTKKD LQQLNEIAEL YNCNNVLFFE ARKHQDLYLW LSKPPNGPTI KFYIQNLHTM 120
  121 DELNFTGNCL KGSRPVLSFD QRFESSPHYQ LIKELLVHNF CVPPNARKSK PFIDHVMSFS 180
  181 IVDDKIWVRT YEISHSTKNK EEYEDGEEDI SLVEIGPRFV MTVILILEGS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
aminoacyl-tRNA ligase activity 3.87211694771248 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 3.87184649959884 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 3.87184649959884 bayes_pls_golite062009
ligase activity 2.64230127203047 bayes_pls_golite062009
proline-tRNA ligase activity 2.35871952544841 bayes_pls_golite062009
binding 1.78917266819015 bayes_pls_golite062009
catalytic activity 0.902495165806215 bayes_pls_golite062009
protein binding 0.665778090365515 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [231-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGGPKIYENK QYVSPNVVRA QIKQQAAEEA KSRAEAAVER KIKRRENVLA ADPLSNDALF  60
   61 K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.542 a.2.3 Chaperone J-domain
View Download 0.441 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.472 a.2.7 tRNA-binding arm
View Download 0.430 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.533 a.51.1 Cytochrome c oxidase subunit h
View Download 0.429 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.422 a.30.1 ROP protein
View Download 0.414 a.46.1 Methionine synthase domain
View Download 0.354 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.328 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.317 d.6.1 Prion-like
View Download 0.314 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.300 a.16.1 S15/NS1 RNA-binding domain
View Download 0.299 f.13.1 Family A G protein-coupled receptor-like
View Download 0.278 a.2.3 Chaperone J-domain
View Download 0.276 a.24.15 FAD-dependent thiol oxidase
View Download 0.274 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.264 a.24.4 Hemerythrin
View Download 0.240 a.2.7 tRNA-binding arm
View Download 0.227 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.217 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.213 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.210 a.64.1 Saposin
View Download 0.203 a.118.11 Cytochrome c oxidase subunit E


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle