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View Structure Prediction Details

Protein: LAG2
Organism: Saccharomyces cerevisiae
Length: 660 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAG2.

Description E-value Query
Range
Subject
Range
LAG2 - Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing ned...
LAG2_YEAST - Cullin-associated NEDD8-dissociated protein 1 homolog OS=Saccharomyces cerevisiae (strain ATCC 20450...
gi|190407318 - gi|190407318|gb|EDV10585.1| longevity-assurance protein 2 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..660] [1..660]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLHISKLIE QYRSTKDNDL KYMLLRQNFK INDIEDELAP LVNELLLPVL VEEQDMEILN  60
   61 LVSFQVLPDL VLSMISDPAA AQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [84-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWVISLICDP LLNQSMIHAN RSFVLIETLR NVLQKIENSP HLDYHQPVNS SLEFISKFIV  60
   61 EMKRHMCDVD AAQLSHSLSE SNMLIYIESL NLLLKFSFFS DAASPSVMVT LPFDILNDVF 120
  121 TIAQDY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [329-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSILNDSLTR TQNENDHGSD NLIDSDDGFG SDNDPEQQAY LDELVSEGYD ENMYDGDTDD  60
   61 EDADDINVEK NDEATKDITE TNKILLIFSE LHYPQEERFS ELLVELQTKI AINTSLIDKI 120
  121 LSKETTELPT HNGEIADLNE ILNEVKGNKP IRKNVIFCTL AHTLSLQSGS ELSVLQLSIE 180
  181 VIDHLLVKNH SNNITRGEQF QLIKLILPHL KTNKSFIDTL KA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.67
Match: 1e6vA
Description: Alpha chain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [210-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SATNTNESID RITEKLLLTS TQLTHPVDLE NLCPKMKYNT LAAVSRIWYK FGPIVDKLFT  60
   61 NRLLPVLFPP QMGEECNVED VLEIVHNFHP YFSIRRLKDN RPLLSDSTIS QLREGLFGM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.67
Match: 1e6vA
Description: Alpha chain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [551-660]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNFTQKIDEG VTLRTMILSL LLQLFPLDYS MLGEILPTIA RYSVRDKDLG VRDLSFQLLD  60
   61 QILRTYYNYL IGIDWEWYKD DFYQVLQETC IKKDINTNLL LQFPPYLPHD 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.59
Match: 1l9uD
Description: DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle