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View Structure Prediction Details

Protein: LAG2
Organism: Saccharomyces cerevisiae
Length: 660 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LAG2.

Description E-value Query
Range
Subject
Range
LAG2 - Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing ned...
LAG2_YEAST - Cullin-associated NEDD8-dissociated protein 1 homolog OS=Saccharomyces cerevisiae (strain ATCC 20450...
gi|190407318 - gi|190407318|gb|EDV10585.1| longevity-assurance protein 2 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..660] [1..660]

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Predicted Domain #1
Region A:
Residues: [1-83]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLHISKLIE QYRSTKDNDL KYMLLRQNFK INDIEDELAP LVNELLLPVL VEEQDMEILN  60
   61 LVSFQVLPDL VLSMISDPAA AQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.414 a.4.1 Homeodomain-like
View Download 0.422 a.74.1 Cyclin-like
View Download 0.570 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.500 a.46.1 Methionine synthase domain
View Download 0.403 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.397 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.394 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.393 a.4.5 "Winged helix" DNA-binding domain
View Download 0.362 a.28.1 ACP-like
View Download 0.350 a.4.5 "Winged helix" DNA-binding domain
View Download 0.331 a.4.5 "Winged helix" DNA-binding domain
View Download 0.325 a.4.5 "Winged helix" DNA-binding domain
View Download 0.315 a.3.1 Cytochrome c
View Download 0.303 a.4.5 "Winged helix" DNA-binding domain
View Download 0.291 a.4.1 Homeodomain-like
View Download 0.286 a.130.1 Chorismate mutase II
View Download 0.285 a.4.5 "Winged helix" DNA-binding domain
View Download 0.282 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.259 a.46.1 Methionine synthase domain
View Download 0.247 a.4.5 "Winged helix" DNA-binding domain
View Download 0.246 a.46.1 Methionine synthase domain
View Download 0.244 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.237 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.236 a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.234 a.1.1 Globin-like
View Download 0.227 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.220 a.4.1 Homeodomain-like
View Download 0.216 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.212 a.130.1 Chorismate mutase II
View Download 0.204 a.4.5 "Winged helix" DNA-binding domain
View Download 0.201 a.4.1 Homeodomain-like
View Download 0.201 a.4.5 "Winged helix" DNA-binding domain
View Download 0.201 a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #2
Region A:
Residues: [84-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GWVISLICDP LLNQSMIHAN RSFVLIETLR NVLQKIENSP HLDYHQPVNS SLEFISKFIV  60
   61 EMKRHMCDVD AAQLSHSLSE SNMLIYIESL NLLLKFSFFS DAASPSVMVT LPFDILNDVF 120
  121 TIAQDY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [329-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSILNDSLTR TQNENDHGSD NLIDSDDGFG SDNDPEQQAY LDELVSEGYD ENMYDGDTDD  60
   61 EDADDINVEK NDEATKDITE TNKILLIFSE LHYPQEERFS ELLVELQTKI AINTSLIDKI 120
  121 LSKETTELPT HNGEIADLNE ILNEVKGNKP IRKNVIFCTL AHTLSLQSGS ELSVLQLSIE 180
  181 VIDHLLVKNH SNNITRGEQF QLIKLILPHL KTNKSFIDTL KA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.67
Match: 1e6vA
Description: Alpha chain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [210-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SATNTNESID RITEKLLLTS TQLTHPVDLE NLCPKMKYNT LAAVSRIWYK FGPIVDKLFT  60
   61 NRLLPVLFPP QMGEECNVED VLEIVHNFHP YFSIRRLKDN RPLLSDSTIS QLREGLFGM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.67
Match: 1e6vA
Description: Alpha chain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [551-660]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNFTQKIDEG VTLRTMILSL LLQLFPLDYS MLGEILPTIA RYSVRDKDLG VRDLSFQLLD  60
   61 QILRTYYNYL IGIDWEWYKD DFYQVLQETC IKKDINTNLL LQFPPYLPHD 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.59
Match: 1l9uD
Description: DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle