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View Structure Prediction Details

Protein: PHO80
Organism: Saccharomyces cerevisiae
Length: 293 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO80.

Description E-value Query
Range
Subject
Range
gi|151945629 - gi|151945629|gb|EDN63870.1| Pho80p cyclin [Saccharomyces cerevisiae YJM789]
PHO80_YEAST - PHO85 cyclin PHO80 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO80 PE=1 SV=3
PHO80 - Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and...
gi|190407341 - gi|190407341|gb|EDV10608.1| Pho80p cyclin [Saccharomyces cerevisiae RM11-1a]
1.0E-95 [1..293] [1..293]
CCNA1 - cyclin A1
1.0E-42 [2..202] [163..377]
CCU22_ARATH - Cyclin-U2-2 OS=Arabidopsis thaliana GN=CYCU2-2 PE=1 SV=1
4.0E-42 [28..211] [25..217]
gi|25493992, gi|... - gi|2982283|gb|AAC32127.1| PREG-like protein [Picea mariana], pir||T52062 PREG-like protein [imported...
2.0E-40 [28..188] [66..222]

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Predicted Domain #1
Region A:
Residues: [1-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESTSGERSE NIHEDQGIPK VILPADFNKC SRTDLVVLIS RMLVSLIAIN ENSATKKSDD  60
   61 QITLTRYHSK IPPNISIFNY FIRLTKFSSL EHCVLMTSLY YIDLLQTVYP DFTLNSLTAH 120
  121 RFLLTATTVA TKGLCDSFST NAHYAKVGGV RCHELNILEN DFLKRVNYRI IPRDHNITLC 180
  181 SIEQKQKKFV IDKNALGSLD LDSYSYVNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 1vin__
Description: Cyclin A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 6.12919068656167 bayes_pls_golite062009
cyclin-dependent protein kinase activity 3.81462270101479 bayes_pls_golite062009
protein kinase regulator activity 2.90083336559452 bayes_pls_golite062009
kinase regulator activity 2.84789294954357 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
nucleic acid binding 2.04886889839181 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.94297811210385 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.86347643875964 bayes_pls_golite062009
enzyme regulator activity 1.65951279073909 bayes_pls_golite062009
protein binding 1.47106731485576 bayes_pls_golite062009
transcription repressor activity 1.42956126861466 bayes_pls_golite062009
transcription factor activity 1.21921365719206 bayes_pls_golite062009
protein kinase activity 0.957590284872001 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.806564872314381 bayes_pls_golite062009
kinase activity 0.79567569649664 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
protein serine/threonine kinase activity 0.567809158275482 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.561985718866596 bayes_pls_golite062009
kinase binding 0.451409627821468 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [210-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSGYNVLDK YYRRIVQLVG SFNASPDKSR KVDYVLPPNI DIVSESGSQT TQLKGSSSPN  60
   61 SHSSQKRYSE AKDAHIYNKR SKPD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle