YRC Public Data Repository - Protein Structure Prediction

Protein:	AIF1
Organism:	Saccharomyces cerevisiae
Length:	378 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AIF1.

Description	E-value	Query Range	Subject Range
FBpp0304195, CG7... - This gene is referred to in FlyBase by the symbol Dmel\CG7430 (CG7430, FBgn0036762). It is a protein... gi\|220946510 - gi\|220946510\|gb\|ACL85798.1\| CG7430-PA [synthetic construct]	6.0E-79	[7..363]	[39..435]
DLDH_CHLMU - Dihydrolipoyl dehydrogenase OS=Chlamydia muridarum (strain MoPn / Nigg) GN=lpdA PE=3 SV=1 DLDH_CHLMU - Dihydrolipoyl dehydrogenase OS=Chlamydia muridarum GN=lpdA PE=3 SV=1	3.0E-78	[6..362]	[5..391]
gi\|10862871 - gi\|10862871\|emb\|CAC13956.1\| glutathione reductase [Mesembryanthemum crystallinum]	5.0E-77	[2..378]	[12..415]
gi\|15966801 - gi\|15966801\|ref\|NP_387154.1\| dihydrolipoamide dehydrogenase [Sinorhizobium meliloti 1021] gi\|15076073 - gi\|15076073\|emb\|CAC47627.1\| Probable dihydrolipoamide dehydrogenase (E3 component of 2-oxoglutarate ...	6.0E-77	[6..363]	[3..400]
gi\|231274220, gi... - gi\|237802986\|ref\|YP_002888180.1\| dihydrolipoamide dehydrogenase [Chlamydia trachomatis], gi\|23127422... gi\|255311375 - gi\|255311375\|ref\|ZP_05353945.1\| dihydrolipoamide dehydrogenase [Chlamydia trachomatis 6276] DLDH_CHLTR - Dihydrolipoyl dehydrogenase OS=Chlamydia trachomatis (strain D/UW-3/Cx) GN=lpdA PE=3 SV=1 gi\|255317676 - gi\|255317676\|ref\|ZP_05358922.1\| dihydrolipoamide dehydrogenase [Chlamydia trachomatis 6276s] gi\|76789294, gi\|... - gi\|76789294\|ref\|YP_328380.1\| dihydrolipoamide dehydrogenase [Chlamydia trachomatis A/HAR-13], gi\|761... DLDH_CHLTR - Dihydrolipoyl dehydrogenase OS=Chlamydia trachomatis GN=lpdA PE=3 SV=1	9.0E-77	[6..362]	[5..391]
gi\|25284939 - pir\|\|AD3270 dihydrolipoamide dehydrogenase (EC 1.8.1.4) [imported] - Brucella melitensis (strain 16M... gi\|17982024, gi\|... - gi\|17986429\|ref\|NP_539063.1\| dihydrolipoamide dehydrogenase [Brucella melitensis 16M], gi\|17982024\|g...	1.0E-76	[5..363]	[2..399]
GSHRP_SPIOL - Glutathione reductase, chloroplastic (Fragment) OS=Spinacia oleracea PE=2 SV=1	1.0E-76	[2..378]	[12..415]
gi\|25284909 - pir\|\|D83981 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase) pdhD [imported] - Bacillus ha... gi\|10175273, gi\|... - gi\|15615215\|ref\|NP_243518.1\| dihydrolipoamide dehydrogenase [Bacillus halodurans C-125], gi\|10175273...	2.0E-76	[4..364]	[8..400]
DLDH3_PSEPU - Dihydrolipoyl dehydrogenase 3 OS=Pseudomonas putida GN=lpd3 PE=1 SV=1	2.0E-76	[3..363]	[1..398]
gi\|8778521, gi\|2... - gi\|8778521\|gb\|AAF79529.1\|AC023673_17 F21D18.28 [Arabidopsis thaliana], pir\|\|F96520 dihydrolipoamide ...	2.0E-76	[4..363]	[40..437]

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Predicted Domain #1

Region A:
Residues: [1-45]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTINTKNIVV VGAGVFGVSV ANHLYRELGG TYAIKLVTAS NYVYF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [58-109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTKSILPLKN VLDSGIEVIK DTAASFDDKE VVLGSDRAIK FDILVLATGS KW

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [243-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISPNVPVNSI SDLCDKKGFI QVEKNFRVKA VEAGNVFAIG DVTNFRYHGL VKRDNWVDVL  60
   61 TRNVISSLQE GTEASLVDAD CLETGHAPSG VSLGPNAGFG QFPLPLLGTI NIPSFLISRA 120
  121 KSKNLFSDKM EPLFKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.512579
Match:	1ndaA_
Description:	Trypanothione reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	3.37477730756688	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.17769237742078	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.86780802427711	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.6431755180135	bayes_pls_golite062009
binding	1.4227698123368	bayes_pls_golite062009
protein binding	1.16738144711505	bayes_pls_golite062009
thioredoxin-disulfide reductase activity	1.11021120187216	bayes_pls_golite062009
oxidoreductase activity	0.48971304115416	bayes_pls_golite062009
disulfide oxidoreductase activity	0.0160065137614933	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [46-57]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPSAVRLTVS KD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [110-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADPIGSTYTF GDNYKEYFER EASRISDADH ILFLGGGFVN CELAGELLFK YLEEIRSGKK  60
   61 RISIIHNSDK LLPDSGLYND TLRKNVTDYL SKNGITLYLN TVGASLDTSP KRIFLGEGSS 120
  121 KYIDADLIYR GVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.512579
Match:	1ndaA_
Description:	Trypanothione reductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: