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View Structure Prediction Details

Protein: FRE4
Organism: Saccharomyces cerevisiae
Length: 719 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE4.

Description E-value Query
Range
Subject
Range
FRE3_YEAST - Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
gi|151945455 - gi|151945455|gb|EDN63698.1| ferric reductase transmembrane component [Saccharomyces cerevisiae YJM78...
FRE3 - Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced...
gi|190407670 - gi|190407670|gb|EDV10937.1| ferric reductase transmembrane component [Saccharomyces cerevisiae RM11-...
0.0 [1..719] [1..711]
RBOHE_ARATH - Respiratory burst oxidase homolog protein E OS=Arabidopsis thaliana GN=RBOHE PE=2 SV=1
0.0 [69..717] [237..948]
gi|17384016 - gi|17384016|emb|CAC87256.1| NADPH oxidase [Nicotiana tabacum]
0.0 [69..717] [244..962]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [69..717] [233..944]
gi|8131846, gi|8... - gi|8131890|gb|AAF73124.1|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi|8131846...
0.0 [69..717] [214..938]

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Predicted Domain #1
Region A:
Residues: [1-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLVHIISFL LFFQLSAAKA PPSKTSLINT HERRSIYSCY VGLRKETWGF NGSAICRYEP  60
   61 AIQSMLYCLY EDTHEKGYSN KTLEKGFEEM RQFCYTPKFL NMTDAEFYTS LDNGTYYIQD 120
  121 QPKAGINITY PIRLNTTLRK AYYDAYYGYY YNHDIPYYFG GIICAYFVGV MLLAGLIRFL 180
  181 NYTPIKKIMF QQKLVNYVRG YTTLPTLYEK HA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [213-336]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPFSYLKVIT GYLPTRFETL VILGYLILHT IFMAYKYQYD PYHIIFAAHR AEVAHFVAYR  60
   61 SGILSFAHLP LIVLFAGRNN FLQLISGLKH TSFIVFHKWL GRMMFLDAII HAAGFTNYYL 120
  121 YYKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.934 N/A N/A a.7.1 Spectrin repeat

Predicted Domain #3
Region A:
Residues: [337-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNTVRLRVYW KFGIATTCLA GMLIFFSIAA FRRHYYETFM ALHIVFAALF LYTCWEHVTN  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
catalytic activity 1.45374095556065 bayes_pls_golite062009
transferase activity 1.15480450573972 bayes_pls_golite062009
binding 1.13408475648113 bayes_pls_golite062009
oxidoreductase activity 0.27336340260908 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
cofactor binding 0.0731141170494622 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [397-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSGIEWIYAA IAIWGVDRIV RITRIALLGF PKADLQLVGS DLVRVTVKKP KKFWKAKPGQ  60
   61 YVFVSFLRPL CFWQSHPFTV MDSCVNDREL VIVLKAKKGV TKLVRNFVER KGGKASMRLA 120
  121 IEGPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [522-646]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSKSTAHRFD NVLLLAGGSG LPGPISHALE LGKTTAASGK NFVQLVIAVR GLDMLNACKK  60
   61 ELMALKGLNV QVHIYNSKQE LASAEKISSN EVKNGETTAE KAPSSLSNSE KAPSESENTE 120
  121 LPLSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1cnf__
Description: Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [647-719]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDTSISDLEF ATFHVGRPNV EEILNESVNH SGSLAVVCCG PPIFVDTARN QTAKAVIRNP  60
   61 SRMIEYLEEY QAW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.833 0.000 plasma membrane d.68.3 SirA-like


YRC Informatics Platform - Version 3.0
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