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View Structure Prediction Details

Protein: AAD14
Organism: Saccharomyces cerevisiae
Length: 376 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AAD14.

Description E-value Query
Range
Subject
Range
AAD14 - Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; ...
AAD14_YEAST - Putative aryl-alcohol dehydrogenase AAD14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...
0.0 [1..376] [1..376]
ALKR4_ARATH - Probable aldo-keto reductase 4 OS=Arabidopsis thaliana GN=At1g60710 PE=2 SV=1
2.0E-98 [19..370] [9..344]
gi|17938565, gi|... - gi|17938565|ref|NP_535354.1| oxidoreductase [Agrobacterium tumefaciens str. C58], gi|17743396|gb|AAL...
gi|25316287, gi|... - pir||AH3156 oxidoreductase mocA [imported] - Agrobacterium tumefaciens (strain C58, Dupont), pir||...
5.0E-97 [16..373] [1..350]
gi|15075864 - gi|15075864|emb|CAC47418.1| Putative oxidoreductase [Sinorhizobium meliloti 1021]
gi|15966592 - gi|15966592|ref|NP_386945.1| putative oxidoreductase protein [Sinorhizobium meliloti 1021]
2.0E-95 [16..353] [1..331]
gi|14027685, gi|... - gi|14027685|dbj|BAB54278.1| oxido-reductase, and dehydratase; MocA [Mesorhizobium loti MAFF303099], ...
6.0E-95 [16..364] [1..337]
gi|2832783 - gi|2832783|emb|CAA12646.1| potassium channel beta subunit [Egeria densa]
2.0E-94 [16..352] [1..328]

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Predicted Domain #1
Region A:
Residues: [1-242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDLFKPLPE PPTELGRLRV LSKTAGIRVS PLILGGASIG DAWSGFMGSM NKEQAFELLD  60
   61 AFYEAGGNCI DTANSYQNEE SEIWIGEWMA SRKLRDQIVI ATKFTGDYKK YEVGGGKSAN 120
  121 YCGNHKRSLH VSVRDSLRKL QTDWIDILYI HWWDYMSSIE EVMDSLHILV QQGKVLYLGV 180
  181 SDTPAWVVSA ANYYATSHGK TPFSVYQGKW NVLNRDFERD IIPMARHFGM ALAPWDVMGG 240
  241 GR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [288-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TESVTAIAIA YVRSKAKNVF PLIGGRKIEH LKQNIEALSI KLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 223.512579
Match: 1exbA_
Description: Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
aldo-keto reductase activity 2.57303336304449 bayes_pls_golite062009
aryl-alcohol dehydrogenase activity 2.5168190536972 bayes_pls_golite062009
catalytic activity 1.68179794468736 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.48881830724998 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47641884930911 bayes_pls_golite062009
binding 1.3044513338497 bayes_pls_golite062009
aldehyde reductase activity 1.16639404121425 bayes_pls_golite062009
ion transmembrane transporter activity 1.11719422559274 bayes_pls_golite062009
cation transmembrane transporter activity 1.04422492638189 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.977252981450468 bayes_pls_golite062009
potassium channel activity 0.728547795239835 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.630972936257947 bayes_pls_golite062009
voltage-gated potassium channel activity 0.523701620407407 bayes_pls_golite062009
voltage-gated cation channel activity 0.502905594729202 bayes_pls_golite062009
voltage-gated ion channel activity 0.459652878315688 bayes_pls_golite062009
voltage-gated channel activity 0.458414323500097 bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity 0.207008954325429 bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 0.207008954325429 bayes_pls_golite062009
protein binding 0.013141318464947 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [243-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQSKKAMEER KKNGEGLRTF VGGPEQTELE VKISEALTKI AEEHG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [331-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEQIEYLESI VPFDVGFPKS LIGDDPAVTK KLSPLTSMSA RIAFDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 223.512579
Match: 1exbA_
Description: Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle