YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: KEX2
Organism: Saccharomyces cerevisiae
Length: 814 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KEX2.

Description E-value Query
Range
Subject
Range
KEX2 - Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in th...
KEX2_YEAST - Kexin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KEX2 PE=1 SV=1
0.0 [1..814] [1..814]
gi|19698549 - gi|19698549|gb|AAL93202.1|AF486805_1 Kex protein [Paracoccidioides brasiliensis]
0.0 [5..755] [2..813]
PCSK6 - proprotein convertase subtilisin/kexin type 6
0.0 [3..648] [41..693]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..648] [41..693]
PCSK6_RAT - Proprotein convertase subtilisin/kexin type 6 OS=Rattus norvegicus GN=Pcsk6 PE=2 SV=1
0.0 [4..619] [29..645]
gi|13183375 - gi|13183375|gb|AAK15173.1|AF292937_1 Kex2 proprotein convertase [Candida glabrata]
0.0 [11..782] [11..791]

Back

Predicted Domain #1
Region A:
Residues: [1-126]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVRKYITLC FWWAFSTSAL VSSQQIPLKD HTSRQYFAVE SNETLSRLEE MHPNWKYEHD  60
   61 VRGLPNHYVF SKELLKLGKR SSLEELQGDN NDHILSVHDL FPRNDLFKRL PVPAPPMDSS 120
  121 LLPVKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.154902
Match: 1kn6A_
Description: Prohormone convertase 1 pro-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [127-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEDKLSINDP LFERQWHLVN PSFPGSDINV LDLWYNNITG AGVVAAIVDD GLDYENEDLK  60
   61 DNFCAEGSWD FNDNTNLPKP RLSDDYHGTR CAGEIAAKKG NNFCGVGVGY NAKISGIRIL 120
  121 SGDITTEDEA ASLIYGLDVN DIYSCSWGPA DDGRHLQGPS DLVKKALVKG VTEGRDSKGA 180
  181 IYVFASGNGG TRGDNCNYDG YTNSIYSITI GAIDHKDLHP PYSEGCSAVM AVTYSSGSGE 240
  241 YIHSSDINGR CSNSHGGTSA AAPLAAGVYT LLLEANPNLT WRDVQYLSIL SAVGLEKNAD 300
  301 GDWRDSAMGK KYSHRYGFGK IDAHKLIEMS KTWENVNAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 145.08661
Match: 1meeA_
Description: Messentericopeptidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nerve growth factor binding 3.24561213884463 bayes_pls_golite062009
neurotrophin binding 2.55889134368092 bayes_pls_golite062009
peptidase activity 1.00880393712776 bayes_pls_golite062009
binding 0.861331602166808 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.786519779876448 bayes_pls_golite062009
catalytic activity 0.597535457699629 bayes_pls_golite062009
endopeptidase activity 0.498073926095918 bayes_pls_golite062009
hydrolase activity 0.409855173053541 bayes_pls_golite062009
serine hydrolase activity 0.163200450825161 bayes_pls_golite062009
serine-type peptidase activity 0.151304815307398 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [466-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TWFYLPTLYV SQSTNSTEET LESVITISEK SLQDANFKRI EHVTVTVDID TEIRGTTTVD  60
   61 LISPAGIISN LGVVRPRDVS SEGFKDWTFM SVAHWGENGV GDWKIKVKTT ENGHRIDFHS 120
  121 WRLKLFGESI DSSKTETFVF GNDKEE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [612-814]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEPAATESTV SQYSASSTSI SISATSTSSI SIGVETSAIP QTTTASTDPD SDPNTPKKLS  60
   61 SPRQAMHYFL TIFLIGATFL VLYFMFFMKS RRRIRRSRAE TYEFDIIDTD SEYDSTLDNG 120
  121 TSGITEPEEV EDFDFDLSDE DHLASLSSSE NGDAEHTIDS VLTNENPFSD PIKQKFPNDA 180
  181 NAESASNKLQ ELQPDVPPSS GRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle