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View Structure Prediction Details

Protein: WHI3
Organism: Saccharomyces cerevisiae
Length: 661 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WHI3.

Description E-value Query
Range
Subject
Range
WHI3_YEAST - Protein WHI3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=WHI3 PE=1 SV=1
WHI3 - RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for ...
0.0 [1..661] [1..661]
gi|12746392 - gi|12746392|gb|AAK07474.1|AF329264_1 CUG-BP and ETR-3 like factor 3 [Homo sapiens]
4.0E-76 [240..627] [54..462]
gi|606976 - gi|606976|gb|AAA81375.1| ribonucleoprotein
6.0E-71 [240..627] [54..462]
gi|26334239, gi|... - gi|74191391|dbj|BAE30277.1| unnamed protein product [Mus musculus], gi|26353506|dbj|BAC40383.1| unna...
6.0E-62 [286..625] [221..553]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-61 [286..625] [221..554]
PTBP3_RAT - Polypyrimidine tract-binding protein 3 OS=Rattus norvegicus GN=Ptbp3 PE=2 SV=1
2.0E-61 [286..625] [191..521]
gi|2136595 - pir||S68857 polypyrimidine tract-binding protein - pig
PTBP1_PIG - Polypyrimidine tract-binding protein 1 OS=Sus scrofa GN=PTBP1 PE=2 SV=1
7.0E-61 [286..625] [222..555]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSSVYFDQT GSFASSSDNV VSSTTNTHNI SPSHRSSLNL NTTSHPHEAS GRGSASGELY  60
   61 LNDTNSPLAI SSMLNTLALG SMPQDIASSN ISNHDNNIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [100-504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSYSLKLSNV AKDITLRECY AIFALAEGVK SIELQKKNSS SSITSASLED ENDIFIIARF  60
   61 ELLNLAINYA VILNSKNELF GPSFPNKTTV EIIDDTTKNL VSFPSSAIFN DTSRLNKSNS 120
  121 GMKRPSLLSQ RSRFSFSDPF SNDSPLSQQQ SQQQQQQPQQ PQQHSTQKHS PQQCNQQQVN 180
  181 SSIPLSSQGQ VIGLHSNHSH QDLSVESTIQ TSDIGKSFLL RDNTEINEKI WGTSGIPSSI 240
  241 NGYMSTPQPS TPTLEWGNTS ASQHGSSFFL PSAASTAIAP TNSNTSANAN ASSNNGASNN 300
  301 GANQALSASS QQPMMQIGNT INTSLTSSNS LPPYGLMSSQ SQHISNMVNT SDMNITPQKQ 360
  361 NRFMQQPQPE HMYPVNQSNT PQKVPPARLS SSRNSHKNNS TTSLS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.98
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [505-661]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNITGSASIS QADLSLLARI PPPANPADQN PPCNTLYVGN LPSDATEQEL RQLFSGQEGF  60
   61 RRLSFRNKNT TSNGHSHGPM CFVEFDDVSF ATRALAELYG RQLPRSTVSS KGGIRLSFSK 120
  121 NPLGVRGPNS RRGGSGNPNP NVNMLSSYNS NVGHIKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.522879
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
mRNA binding 2.76744192669109 bayes_pls_golite062009
RNA binding 2.41328743949172 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle