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View Structure Prediction Details

Protein: SRV2
Organism: Saccharomyces cerevisiae
Length: 526 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRV2.

Description E-value Query
Range
Subject
Range
CAP2 - CAP, adenylate cyclase-associated protein, 2 (yeast)
gi|61361754, gi|... - gi|61361754|gb|AAX42098.1| CAP adenylate cyclase-associated protein 2 [synthetic construct], gi|1239...
0.0 [11..524] [2..475]
CAP2_MOUSE - Adenylyl cyclase-associated protein 2 OS=Mus musculus GN=Cap2 PE=1 SV=1
0.0 [12..524] [3..474]
CAP2_RAT - Adenylyl cyclase-associated protein 2 OS=Rattus norvegicus GN=Cap2 PE=1 SV=1
0.0 [11..524] [2..475]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [11..526] [2..474]
SRV2 - CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cycl...
CAP_YEAST - Adenylyl cyclase-associated protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRV2...
0.0 [1..526] [1..526]
gi|31747011, gi|... - gi|31747011|gb|AAP57716.1| cyclase-associated protein 1a [Xenopus laevis], gi|27370990|gb|AAH41224.1...
0.0 [11..526] [2..475]
gi|13874486 - gi|13874486|dbj|BAB46867.1| hypothetical protein [Macaca fascicularis]
0.0 [109..524] [1..399]

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Predicted Domain #1
Region A:
Residues: [1-39]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDSKYTMQG YNLVKLLKRL EEATARLEDV TIYQEGYIQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [80-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AFQSYIGENI DPLVELSGKI DTVVLDALQL LKGGFQSQLT FLRAAVRS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [136-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFADSLRPIN ENIIKLGQLK ESNRQSKYFA YLSALSEGAP LFSWVAVDTP VSMVTDFKDA  60
   61 AQFWTNRILK EYRESDPNAV EWVKKFLASF DNLKAYIKEY HTTGVSWKKD GM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.03
Match: 1k7lA
Description: Peroxisome proliferator activated receptor alpha, PPAR-alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 5.81884714997094 bayes_pls_golite062009
cytoskeletal protein binding 4.39652693178112 bayes_pls_golite062009
adenylate cyclase binding 2.08284870927262 bayes_pls_golite062009
binding 1.8340549733034 bayes_pls_golite062009
enzyme binding 1.53072876683435 bayes_pls_golite062009
protein binding 0.871734119777931 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [40-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKLEASKNNK PSDSGADANT TNEPSAENAP EVEQDPKCIT 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [128-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKPDYSSQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.03
Match: 1k7lA
Description: Peroxisome proliferator activated receptor alpha, PPAR-alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [248-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFADAMAQST KNTGATSSPS PASATAAPAP PPPPPAPPAS VFEISNDTPA TSSDANKGGI  60
   61 GAVFAELNQG ENITKGLKKV DKSQQTHKNP ELRQSSTVSS TGSKSG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.338 0.066 adenylate cyclase binding a.74.1 Cyclin-like

Predicted functions:

Term Confidence Notes
actin binding 4.94933252861141 bayes_pls_golite062009
cytoskeletal protein binding 4.21664682046338 bayes_pls_golite062009
actin monomer binding 2.04365563273836 bayes_pls_golite062009
binding 1.57578562719958 bayes_pls_golite062009
adenylate cyclase binding 1.13353932343086 bayes_pls_golite062009
enzyme binding 0.705135358375 bayes_pls_golite062009
protein binding 0.651719649953198 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [354-526]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPRPKKPST LKTKRPPRKE LVGNKWFIEN YENETESLVI DANKDESIFI GKCSQVLVQI  60
   61 KGKVNAISLS ETESCSVVLD SSISGMDVIK SNKFGIQVNH SLPQISIDKS DGGNIYLSKE 120
  121 SLNTEIYTSC STAINVNLPI GEDDDYVEFP IPEQMKHSFA DGKFKSAVFE HAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 920.9897
Match: 1k4zA_
Description: C-terminal domain of adenylylcyclase associated protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle