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View Structure Prediction Details

Protein: MLS1
Organism: Saccharomyces cerevisiae
Length: 554 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLS1.

Description E-value Query
Range		 Subject
Range
MASY_YEAST - Malate synthase 1, glyoxysomal OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MLS1 PE=1...
MLS1 - Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon s...
 0.0 [1..554] [1..554]
MASY_SOYBN - Malate synthase, glyoxysomal (Fragment) OS=Glycine max PE=2 SV=1
 0.0 [12..554] [17..564]
MASY_GOSHI - Malate synthase, glyoxysomal OS=Gossypium hirsutum PE=2 SV=1
 0.0 [5..553] [13..565]
MASY_RICCO - Malate synthase, glyoxysomal OS=Ricinus communis PE=2 SV=1
 0.0 [10..554] [17..567]
MASY_BRANA - Malate synthase, glyoxysomal OS=Brassica napus PE=2 SV=1
 0.0 [8..554] [11..561]
MASY_ARATH - Malate synthase OS=Arabidopsis thaliana GN=MLS PE=1 SV=1
 0.0 [8..554] [11..562]
MASY_CUCSA - Malate synthase, glyoxysomal OS=Cucumis sativus PE=2 SV=2
 0.0 [11..554] [20..568]

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Predicted Domain #1
Region A:
Residues: [1-104] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKVSLDNVK LLVDVDKEPF FKPSSTTVGD ILTKDALEFI VLLHRTFNNK RKQLLENRQV  60
   61 VQKKLDSGSY HLDFLPETAN IRNDPTWQGP ILAPGLINRS TEIT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.93
Match: 1d8cA
Description: Malate synthase G
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 4.27762948199878 bayes_pls_golite062009
transferase activity, transferring acyl groups 2.61158006337608 bayes_pls_golite062009
catalytic activity 1.23634637968745 bayes_pls_golite062009
transferase activity 0.263512092168681 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [105-421] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPPLRNMLIN ALNAPVNTYM TDFEDSASPT WNNMVYGQVN LYDAIRNQID FDTPRKSYKL  60
   61 NGNVANLPTI IVRPRGWHMV EKHLYVDDEP ISASIFDFGL YFYHNAKELI KLGKGPYFYL 120
  121 PKMEHHLEAK LWNDVFCVAQ DYIGIPRGTI RATVLIETLP AAFQMEEIIY QLRQHSSGLN 180
  181 CGRWDYIFST IKRLRNDPNH ILPNRNQVTM TSPFMDAYVK RLINTCHRRG VHAMGGMAAQ 240
  241 IPIKDDPAAN EKAMTKVRND KIRELTNGHD GSWVAHPALA PICNEVFINM GTPNQIYFIP 300
  301 ENVVTAANLL ETKIPNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 138.228787
Match: 1d8cA_
Description: Malate synthase G
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [422-554] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EITTEGIVQN LDIGLQYMEA WLRGSGCVPI NNLMEDAATA EVSRCQLYQW VKHGVTLKDT  60
   61 GEKVTPELTE KILKEQVERL SKASPLGDKN KFALAAKYFL PEIRGEKFSE FLTTLLYDEI 120
  121 VSTKATPTDL SKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 138.228787
Match: 1d8cA_
Description: Malate synthase G
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle