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View Structure Prediction Details

Protein: IMP4
Organism: Saccharomyces cerevisiae
Length: 290 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMP4.

Description E-value Query
Range
Subject
Range
gi|190409064 - gi|190409064|gb|EDV12329.1| U3 small nucleolar ribonucleoprotein protein IMP4 [Saccharomyces cerevis...
IMP4_YEAST - U3 small nucleolar ribonucleoprotein protein IMP4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
gi|207341687 - gi|207341687|gb|EDZ69673.1| YNL075Wp-like protein [Saccharomyces cerevisiae AWRI1631]
IMP4 - Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10...
7.0E-90 [1..290] [1..290]
gi|12850634, gi|... - gi|30519917|ref|NP_848716.1| U3 snoRNP protein 4 homolog [Mus musculus], gi|12850634|dbj|BAB28797.1|...
3.0E-82 [1..290] [1..288]
IMP4 - IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
gi|124000169, gi... - gi|157929232|gb|ABW03901.1| IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) [synthetic c...
2.0E-81 [1..290] [1..288]
CE18464 - status:Confirmed UniProt:O62518 protein_id:CAB05841.1
3.0E-81 [1..290] [1..283]
gi|32405940, gi|... - gi|32405940|ref|XP_323583.1| probable component of the U3 small nucleolar ribonucleoprotein [MIPS] [...
gi|85101912 - gi|85101912|ref|XP_961234.1| U3 small nucleolar ribonucleoprotein protein IMP4 [Neurospora crassa OR...
7.0E-81 [1..289] [1..294]
IMP4_SCHPO - U3 small nucleolar ribonucleoprotein protein imp4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24...
SPAC19A8.07c - U3 snoRNP-associated protein Imp4
4.0E-80 [1..290] [1..287]
gi|19577368, gi|... - gi|42820709|emb|CAF32022.1| imp4 protein, putative [Aspergillus fumigatus], gi|19577368|emb|CAD28449...
gi|66850312, gi|... - gi|70995844|ref|XP_752677.1| U3 small nucleolar ribonucleoprotein protein IMP4 [Aspergillus fumigatu...
2.0E-79 [1..290] [1..299]
gi|20260206, gi|... - pir||H96662 hypothetical protein T12P18.20 [imported] - Arabidopsis thaliana, gi|21593725|gb|AAM656...
6.0E-77 [1..290] [1..292]
gi|4262378 - gi|4262378|gb|AAD14602.1| stage specific peptide 24 [Trypanosoma cruzi]
7.0E-77 [1..290] [1..287]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRRQARERR EYLYRKAQEL QDSQLQQKRQ IIKQALAQGK PLPKELAEDE SLQKDFRYDQ  60
   61 SLKESEEADD LQVDDEYAAT SGIMDPR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.639 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.642 a.2.7 tRNA-binding arm
View Download 0.646 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.696 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.696 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.657 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.657 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.646 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.642 a.2.7 tRNA-binding arm
View Download 0.639 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.625 a.2.7 tRNA-binding arm
View Download 0.623 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.622 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.616 a.26.1 4-helical cytokines
View Download 0.577 a.30.1 ROP protein
View Download 0.572 i.1.1 Ribosome and ribosomal fragments
View Download 0.534 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.532 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.531 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.522 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.515 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.515 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.515 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.493 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.491 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.482 a.25.1 Ferritin-like
View Download 0.474 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.466 a.7.6 Ribosomal protein S20
View Download 0.465 a.47.2 t-snare proteins
View Download 0.456 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.452 a.2.7 tRNA-binding arm
View Download 0.451 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.439 a.63.1 Apolipophorin-III
View Download 0.430 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.430 a.55.1 IHF-like DNA-binding proteins
View Download 0.419 a.4.1 Homeodomain-like
View Download 0.419 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.415 a.7.6 Ribosomal protein S20
View Download 0.376 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.371 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.354 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.342 a.7.7 BAG domain
View Download 0.331 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.330 a.7.1 Spectrin repeat
View Download 0.330 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.313 a.7.6 Ribosomal protein S20
View Download 0.313 a.7.6 Ribosomal protein S20
View Download 0.312 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.311 a.47.2 t-snare proteins
View Download 0.309 f.17.2 Cytochrome c oxidase subunit II-like, transmembrane region
View Download 0.299 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.297 a.7.6 Ribosomal protein S20
View Download 0.295 a.7.1 Spectrin repeat
View Download 0.294 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.293 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.290 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.287 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.283 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.282 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.280 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.275 a.47.2 t-snare proteins
View Download 0.269 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.269 a.77.1 DEATH domain
View Download 0.267 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.265 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.265 i.1.1 Ribosome and ribosomal fragments
View Download 0.262 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.259 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.253 a.74.1 Cyclin-like
View Download 0.246 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.246 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.239 a.74.1 Cyclin-like
View Download 0.239 a.7.1 Spectrin repeat
View Download 0.238 a.133.1 Phospholipase A2, PLA2
View Download 0.238 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.234 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.234 a.7.6 Ribosomal protein S20
View Download 0.227 a.7.6 Ribosomal protein S20
View Download 0.223 d.8.1 Urease, gamma-subunit
View Download 0.221 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.220 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.218 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.216 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.216 a.7.7 BAG domain
View Download 0.216 a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 a.130.1 Chorismate mutase II
View Download 0.212 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.209 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.209 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.208 d.58.4 Dimeric alpha+beta barrel
View Download 0.205 a.118.1 ARM repeat
View Download 0.204 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.201 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.200 a.2.7 tRNA-binding arm

Predicted Domain #2
Region A:
Residues: [88-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIVTTSRDPS TRLSQFAKEI KLLFPNAVRL NRGNYVMPNL VDACKKSGTT DLVVLHEHRG  60
   61 VPTSLTISHF PHGPTAQFSL HNVVMRHDII NAGNQSEVNP HLIFDNFTTA LGKRVVCILK 120
  121 HLFNAGPKKD SERVITFANR GDFISVRQHV YVRTREGVEI AEVGPRFEMR LFELRLGTLE 180
  181 NKDADVEWQL RRFIRTANKK DYL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 87.017729
Match: PF01945
Description: No description for PF01945 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
aminoacyl-tRNA ligase activity 3.58650371779212 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 3.58624422951947 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 3.58624422951947 bayes_pls_golite062009
ligase activity 2.71574082295198 bayes_pls_golite062009
proline-tRNA ligase activity 2.35871952544841 bayes_pls_golite062009
binding 1.73857064375258 bayes_pls_golite062009
catalytic activity 0.902495165806215 bayes_pls_golite062009
protein binding 0.358563180490135 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [177-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INAGNQSEVN PHLIFDNFTT ALGKRVVCIL KHLFNAGPKK DSERVITFAN RGDFISVRQH  60
   61 VYVRTREGVE IAEVGPRFEM RLFELRLGTL ENKDADVEWQ LRRFIRTANK KDYL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.84
Match: 1w94A
Description: Crystal Structure of Mil (Mth680), an archaeal Imp4-like protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle