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View Structure Prediction Details

Protein: PUB1
Organism: Saccharomyces cerevisiae
Length: 453 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUB1.

Description E-value Query
Range
Subject
Range
gi|2665654 - gi|2665654|gb|AAB88449.1| polyadenylate binding protein [Petromyzon marinus]
0.0 [66..453] [2..420]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
0.0 [66..452] [2..417]
PABP1_MOUSE - Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2
0.0 [66..452] [2..417]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
0.0 [66..452] [2..417]
gi|64970 - gi|64970|emb|CAA40721.1| polyA binding protein [Xenopus laevis]
0.0 [66..453] [2..417]
gi|19526272 - gi|19526272|gb|AAL89666.1|AF411956_7 polyA-binding protein [Takifugu rubripes]
0.0 [71..452] [7..416]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSENNEEQHQ QQQQQQPVAV ETPSAVEAPA SADPSSEQSV AVEGNSEQAE DNQGENDPSV  60
   61 VPANAITGGR ETSDRVLYVG NLDKAITEDI LKQYFQVGGP IANIKIMIDK NNKNVNYAFV 120
  121 EYHQSHDANI ALQTLNGKQI ENNIVKINWA FQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 261.211549
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
4.08350076268185 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
structural molecule activity 2.78501986457503 bayes_pls_golite062009
poly-pyrimidine tract binding 2.47215943693079 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
snRNA binding 1.12690941758278 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.425042944899091 bayes_pls_golite062009
hydrolase activity 0.389390547875764 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [153-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQQSSSDDTF NLFVGDLNVN VDDETLRNAF KDFPSYLSGH VMWDMQTGSS RGYGFVSFTS  60
   61 QDDAQNAMDS MQGQDLNGRP LRINWAAKRD NNNNNNYQQR RNYGNNNRGG FRQYNSNNNN 120
  121 NMN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 261.211549
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [276-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGMNMNMNMN MNNSRGMPPS SMGMPIGAMP LPSQGQPQQS QTIGLPPQVN PQAVDH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [332-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIRSAPPRVT TAYIGNIPHF ATEADLIPLF QNFGFILDFK HYPEKGCCFI KYDTHEQAAV  60
   61 CIVALANFPF QGRNLRTGWG KERSNFMPQQ QQQGGQPLIM NDQQQPVMSE QQQQQQQQQQ 120
  121 QQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.045757
Match: 1bnyA_
Description: No description for 1bnyA_ was found.

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