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View Structure Prediction Details

Protein: HSH155
Organism: Saccharomyces cerevisiae
Length: 971 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSH155.

Description E-value Query
Range
Subject
Range
SF3B1_MOUSE - Splicing factor 3B subunit 1 OS=Mus musculus GN=Sf3b1 PE=1 SV=1
0.0 [72..971] [387..1304]
SF3B1_YEAST - U2 snRNP component HSH155 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSH155 PE=1 SV...
HSH155 - U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice...
0.0 [1..971] [1..971]
SF3B1_XENLA - Splicing factor 3B subunit 1 OS=Xenopus laevis GN=sf3b1 PE=2 SV=1
0.0 [72..971] [390..1307]
CE03641 - status:Partially_confirmed UniProt:Q21909 protein_id:CAA90777.1
0.0 [70..971] [392..1322]
gi|15237657, gi|... - gi|9759403|dbj|BAB09858.1| nuclear protein-like [Arabidopsis thaliana], gi|15237657|ref|NP_201232.1|...
0.0 [72..971] [350..1267]
SF3B1_SCHPO - U2 snRNP component prp10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp10 PE=1 SV=2
prp10 - U2 snRNP-associated protein Sap155
0.0 [22..960] [270..1192]
SF3B1_SCHPO - U2 snRNP component prp10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp10 PE=1 SV=2
prp10 - U2 snRNP-associated protein Sap155
0.0 [22..960] [253..1175]
gi|7494200 - pir||T18434 hypothetical protein C0375c - malaria parasite (Plasmodium falciparum)
gi|16805179, gi|... - gi|3649762|emb|CAB11111.1| U2 snRNP spliceosome subunit, putative [Plasmodium falciparum 3D7], gi|16...
0.0 [119..971] [531..1386]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHPIQFVNA NNSDKSHQLG GQYSIPQDLR ENLQKEAARI GENEKDVLQE KMETRTVQNR  60
   61 EDSYHKRRFD M

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [72-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFEPDSDTQT VTSSENTQDA VVPRKRKSRW DVKGYEPPDE SSTAVKENSD SALVNVEGIH  60
   61 DLMFFKPSDH KYFADVISKK PIDELNKDEK KERTLSMLLL KI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [174-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNGNTASRRT SMRILTDKAV TFGPEMIFNR LLPILLDRSL EDQERHLMIK TIDRVLYQLG  60
   61 DLTKPYVHKI LVVAAPLLID 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.964 0.054 U2 snRNP a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #4
Region A:
Residues: [254-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDPMVRSTGQ EIITNLSTVA GLKTILTVMR PDIENEDEYV RNVTSRAAAV VAKALGVNQL  60
   61 LPFINAACHS RKSWKARHTG IKIVQQIGIL LGIGVLNHLT GLMSCIKDCL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.39794
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.20683443264388 bayes_pls_golite062009
binding 2.91891696274037 bayes_pls_golite062009
mRNA binding 2.49094746544717 bayes_pls_golite062009
protein binding 1.75981610748679 bayes_pls_golite062009
nucleic acid binding 1.64539435934931 bayes_pls_golite062009
structural molecule activity 1.39201458088376 bayes_pls_golite062009
transcription regulator activity 1.06250847754412 bayes_pls_golite062009
DNA binding 0.946847037737779 bayes_pls_golite062009
RNA cap binding 0.66277586901495 bayes_pls_golite062009
transcription factor activity 0.362911773502049 bayes_pls_golite062009
signal sequence binding 0.289133192719901 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [364-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDHVPVRIV TAHTLSTLAE NSYPYGIEVF NVVLEPLWKG IRSHRGKVLS SFLKAVGSMI  60
   61 PLMDPEYAGY YTTEAMRIIR REFDSPDDEM KKTILLVLQK CSAVESITPK FLREEIAPEF 120
  121 FQKFWVRRVA LDRPLNKVVT YTTVTLAKKL GCSYTIDKLL TPLRDEAEPF RTMAVHAVTR 180
  181 TVNLLGTADL DERLETRLID ALLIAFQEQT NSDSIIFKGF GAVTVSLDIR MKPFLAPIVS 240
  241 TILNHLKHKT PLVRQHAADL CAILIPVIKN CHEFEMLNKL NIILYESLGE VYPEVLGSII 300
  301 NAMYCITSVM DLDKLQPPIN QILPTLTPIL RNKHRKVEVN TIKFVGLIGK LAPTYAPPKE 360
  361 WMRICFELLE LLKSTNKEIR RSAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [748-971]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATFGFIAEAI GPHDVLVALL NNLKVQERQL RVCTAVAIGI VAKVCGPYNV LPVIMNEYTT  60
   61 PETNVQNGVL KAMSFMFEYI GNMSKDYIYF ITPLLEDALT DRDLVHRQTA SNVITHLALN 120
  121 CSGTGHEDAF IHLMNLLIPN IFETSPHAIM RILEGLEALS QALGPGLFMN YIWAGLFHPA 180
  181 KNVRKAFWRV YNNMYVMYQD AMVPFYPVTP DNNEEYIEEL DLVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle