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View Structure Prediction Details

Protein: NGL2
Organism: Saccharomyces cerevisiae
Length: 515 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NGL2.

Description E-value Query
Range
Subject
Range
gi|190408511 - gi|190408511|gb|EDV11776.1| RNase [Saccharomyces cerevisiae RM11-1a]
NGL2 - Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of ...
NGL2_YEAST - RNA exonuclease NGL2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NGL2 PE=1 SV=1
0.0 [1..515] [1..515]
gi|21362313, gi|... - gi|21362313|ref|NP_653107.1| angel homolog 1 [Mus musculus], gi|17512364|gb|AAH19148.1| Angel homolo...
4.0E-93 [16..514] [135..663]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-90 [27..514] [154..669]
SPBC9B6.11c - CCR4 /nocturin family endoribonuclease
YNTB_SCHPO - Probable RNA exonuclease C9B6.11c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC9B6....
2.0E-88 [28..513] [34..501]
gi|6330365 - gi|6330365|dbj|BAA86508.1| KIAA1194 protein [Homo sapiens]
6.0E-79 [77..515] [176..560]

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Predicted Domain #1
Region A:
Residues: [1-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQDKEVKVV APDVAPDQEV EINKSVKDAK HQTNDDSLLQ HKKKGKKGKK SKPIVTPEHI  60
   61 AKVRAEREVM RKAKRDAMLA QGVDPDCPPE LHFIRRPFLS LHEAEPVTGF RFKLMTYNCL 120
  121 AQALIRRKLF PDSGDALKWY RRSKVLLNEF KYYNSDVICL QEIDHIQFQS FWKDEFSKLG 180
  181 YDGQYYRNAT KNHGVAIMWR RELFHQVDKM LIDYDKESSE SISTRTTTNN VGLVLALKFS 240
  241 EKVLSNLGKK SSKKCGILIG TTHLFWHPFG TYERTRQCYI VLKKMKEFMH RVNVLQNEND 300
  301 GDLSHWFPFF CGDFNSQPFD TPYLSMTSKP VHYRNRAKTV IGCSTSYKFS KVRDGEEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.30103
Match: 1hd7A_
Description: DNA repair endonuclease Hap1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [359-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADDEEGGNIE KYGKDQPESP VPEKFHANEE QSELVDKMAQ LHNSLDMRAI SLYSVGYKNV  60
   61 HPENAGLDND RGEPEISNWA NTWRGLLDYL FYVKKWDPQS NCQEVETLGD FEKENKVKCR 120
  121 GFLRMPPGNE MTKHGQPHVG EYASDHLSMV CDLELQL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
catalytic activity 1.63030570728465 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.39690524605979 bayes_pls_golite062009
DNA binding 1.34290873898836 bayes_pls_golite062009
transcription regulator activity 1.27719902384019 bayes_pls_golite062009
nucleic acid binding 1.26094583634346 bayes_pls_golite062009
binding 1.17923253861699 bayes_pls_golite062009
hydrolase activity 1.0186117087165 bayes_pls_golite062009
nuclease activity 0.971472202981676 bayes_pls_golite062009
exonuclease activity 0.60038717760287 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.488526496507674 bayes_pls_golite062009
deoxyribonuclease activity 0.474030643465787 bayes_pls_golite062009
protein binding 0.245882909879445 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.137139876726156 bayes_pls_golite062009
phosphatase activity 0.0361187050412868 bayes_pls_golite062009
transcription activator activity 0.0201905540007417 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle