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View Structure Prediction Details

Protein: GAD1
Organism: Saccharomyces cerevisiae
Length: 585 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAD1.

Description E-value Query
Range
Subject
Range
GAD1 - Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate cat...
gi|151945957 - gi|151945957|gb|EDN64189.1| glutamate decarboxylase [Saccharomyces cerevisiae YJM789]
gi|190408476 - gi|190408476|gb|EDV11741.1| glutamate decarboxylase [Saccharomyces cerevisiae RM11-1a]
DCE_YEAST - Glutamate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAD1 PE=1 SV=1
0.0 [1..585] [1..585]
DCE4_ARATH - Glutamate decarboxylase 4 OS=Arabidopsis thaliana GN=GAD4 PE=1 SV=1
0.0 [31..559] [1..486]
DCE_PETHY - Glutamate decarboxylase OS=Petunia hybrida GN=GAD PE=1 SV=1
0.0 [31..562] [1..482]
amd-PA - The gene Ã?ŽÃ?± methyl dopa-resistant is referred to in FlyBase by the symbol Dmel\amd (CG1050...
0.0 [7..551] [1..504]
gi|112984466, gi... - gi|13899133|gb|AAK48988.1|AF372836_1 dopa decarboxylase [Bombyx mori], gi|112984466|ref|NP_001037174...
0.0 [7..529] [1..473]
gi|113623967, gi... - gi|50946625|ref|XP_482840.1| glutamate decarboxylase [Oryza sativa (japonica cultivar-group)], gi|42...
0.0 [48..570] [22..496]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLHRHGSKQK NFENIAGKVV HDLAGLQLLS NDVQKSAVQS GHQGSNNMRD TSSQGMANKY  60
   61 SVPKKGLPAD LSYQLIHNEL TLDGN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 107.0
Match: 1js3A_
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity 1.44093490824786 bayes_pls_golite062009
glutamate decarboxylase activity 1.34215658716536 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.05524734914785 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.05524734914785 bayes_pls_golite062009
binding 0.252160165096264 bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity 0.223759435414525 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 0.13686553668007 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [86-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHLNLASFVN TFTTDQARKL IDENLTKNLA DNDEYPQLIE LTQRCISMLA QLWHANPDEE  60
   61 PIGCATTGSS EAIMLGGLAM KKRWEHRMKN AGKDASKPNI IMSSACQVAL EKFTRYFEVE 120
  121 CRLVPVSHRS HHMLDPESLW DYVDENTIGC FVILGTTYTG HLENVEKVAD VLSQIEAKHP 180
  181 DWSNTDIPIH ADGASGGFII PFGFEKEHMK AYGMERWGFN HPRVVSMNTS GHKFGLTTPG 240
  241 LGWVLWRDES LLADELRFKL KYLGGVEETF GLNFSRPGFQ VVHQYFNFVS LGHSGYRTQF 300
  301 QNSLFVARAF SFELLNSSKL PGCFEIVSSI HESIENDSAP KSVKDYWEHP QAYKPGVPLV 360
  361 AFKLSKKFHE EYPEVPQAIL SSLLRGRGWI IPNYPLPKAT DGSDEKEVLR VVFRSEMKLD 420
  421 LAQLLIVDIE SILTKLIHSY EKVCHHIELA SEQTPERKSS FIYEMLLALA SPQDDIPTPD 480
  481 EIEKKNKLKE TTTRNYRGTC 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 107.0
Match: 1js3A_
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle