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View Structure Prediction Details

Protein: CTL1
Organism: Saccharomyces cerevisiae
Length: 320 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CTL1.

Description E-value Query
Range
Subject
Range
CTL1 - RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
gi|190408404 - gi|190408404|gb|EDV11669.1| RNA triphosphatase [Saccharomyces cerevisiae RM11-1a]
CTL1_YEAST - Polynucleotide 5'-triphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTL1 PE...
0.0 [1..320] [1..320]
CET1_CANAL - mRNA-capping enzyme subunit beta OS=Candida albicans GN=CET1 PE=3 SV=2
CET1_CANAL - mRNA-capping enzyme subunit beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CET1 PE=3 SV...
3.0E-67 [72..304] [270..508]
pct1 - RNA 5'-triphosphatase
CET1_SCHPO - mRNA-capping enzyme subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pct1 PE=1...
4.0E-61 [81..281] [72..266]

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Predicted Domain #1
Region A:
Residues: [1-57]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQPETPSN SRNSHENVGA KKADANVASK FRSLHISETT KPLTSTRALY KTTRNNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.372 a.4.1 Homeodomain-like
View Download 0.391 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.269 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.389 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.233 d.48.1 RecA protein, C-terminal domain
View Download 0.233 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.230 a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.223 a.30.1 ROP protein
View Download 0.218 a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.203 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.200 a.144.1 PABC (PABP) domain

Predicted functions:

Term Confidence Notes
binding 1.32114964285132 bayes_pls_golite062009
catalytic activity 1.17990683373825 bayes_pls_golite062009
hydrolase activity 0.709889322437172 bayes_pls_golite062009
polynucleotide 5'-phosphatase activity 0.435579003310852 bayes_pls_golite062009
protein binding 0.17471074625109 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [58-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGATEFHKHV CKLAWKYLAC IDKSSISHIE IEMKFGVITD KRTHRRMTPH NKPFIVQNRN  60
   61 GRLVSNVPEQ MFSSFQELLR SKSENPSKCA PRVVKQVQKY TKDSIYNCNN ASKVGKLTSW 120
  121 RCSEDLRNKE LKLTYIKKVR VKDFLIRYPQ SSLDAKISIS LEVPEYETSA AFRNGFILQR 180
  181 TKSRSTYTFN DKMPLHLDLT KVTTTRRNSH QYTSHEVEVE MDPIFKETIS ANDREKFNEY 240
  241 MCSFLNASDL IRKAAERDNM LTT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 224.67837
Match: 1d8hA_
Description: mRNA triphosphatase CET1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle