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View Structure Prediction Details

Protein: ECM5
Organism: Saccharomyces cerevisiae
Length: 1411 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECM5.

Description E-value Query
Range
Subject
Range
ECM5_YEAST - Protein ECM5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ECM5 PE=1 SV=1
ECM5 - Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibi...
0.0 [1..1411] [1..1411]
gi|19923370, gi|... - gi|6572291|emb|CAB63108.1| RB-binding protein [Homo sapiens], ref|NP_006609.2| Jumonji, AT rich inte...
0.0 [94..1367] [144..1427]
FBpp0311492, FBp... - The gene little imaginal discs is referred to in FlyBase by the symbol Dmel\lid (CG9088, FBgn0031759...
0.0 [105..1393] [148..1448]
gi|9937325 - gi|9937325|gb|AAG02418.1|AF286030_1 regulator Ustilago maydis 1 protein; Rum1
0.0 [95..1371] [207..1560]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [246..1367] [42..1096]
gi|25404909, gi|... - gi|6633837|gb|AAF19696.1|AC008047_3 F2K11.14 [Arabidopsis thaliana], pir||D96660 protein F2K11.14 [i...
0.0 [96..1191] [11..1065]
gi|16944479, gi|... - gi|32412502|ref|XP_326731.1| hypothetical protein [Neurospora crassa], gi|28923151|gb|EAA32368.1| hy...
gi|85103796 - gi|85103796|ref|XP_961604.1| hypothetical protein NCU01238 [Neurospora crassa OR74A]
0.0 [282..1386] [383..1473]
LID2_SCHPO - Lid2 complex component lid2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lid2 PE=1 SV=1
lid2 - Lid2 complex subunit Lid2
0.0 [130..1385] [68..1235]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGHDSVTKI SHILNEPVNE KVMVQNGFHE SSKIADIELE IQERPSIKQW ESPRSAVIPT  60
   61 SNHNFSPFLY TQFKSRGAAP FAPETIKSVD LVELPEGVPA RVFHEKTGLF YQIS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [115-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSIPTFILA KKELPDPIKF YELVEDLGSV YGCVKLKIIP DADKFTQLNV DVDRLWFKAR  60
   61 KQFFNSNEFQ RTKIVDFYAK LYNFHNKIKK STLTRIP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.0103
Match: 1kqqA_
Description: DNA-binding domain from the dead ringer protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [212-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIDKRTLDLY RLRSCVKLRG GFNAVCEKKL WAQIGRELGY SGRIMSSLST SLRSAYAKIL  60
   61 LDFDIYEEEE QAARNNEKNE DMVESEIFRH SNSRSRDEEE PLHKKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.0103
Match: 1kqqA_
Description: DNA-binding domain from the dead ringer protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.82429745664596 bayes_pls_golite062009
nucleic acid binding 1.96196521368194 bayes_pls_golite062009
DNA binding 1.95175882800914 bayes_pls_golite062009
transcription regulator activity 1.69129851237145 bayes_pls_golite062009
transcription coactivator activity 0.9777334079728 bayes_pls_golite062009
protein binding 0.923807406971133 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.89101605547219 bayes_pls_golite062009
transcription activator activity 0.302416902310042 bayes_pls_golite062009
transcription factor activity 0.143417837230029 bayes_pls_golite062009
transcription factor binding 0.0217863068537998 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [318-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIHRDVFRAG SINHEFKRMR DIKHIKGFPT YFNSLTEFKL GYTQSTETTL PGYDFTFWEN  60
   61 GMEIYDKSKY ETKTSPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [395-739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNLRQYYEKS LAVFTAIVAK FGSSYPDLFA KHTTLPQKEF ERLYFHLLSE HFIDFEIDTG  60
   61 LGLPCSMRSP GNNSSNEKFA IKNILDQWNL DNIPLNELSL LQHLDLDMAN FTRTTYDIGM 120
  121 LFSCQGWSVS DHFLPSIDFN HLGSTKLVYS IAPKDMEKFE ALIARGKSEW DTIQSRPRYS 180
  181 TSDDELKSFI ETDFYKSFLD AEQSADYSNT GDNSKNSFPE DKIAGNTLHD GSQSDFIFEP 240
  241 NFILANGIKL YKTTQEQGSY IFKFPKAFTC SIGSGFYLSQ NAKFAPSSWL RFSSEAAKWT 300
  301 SKMGFLPGLD VNQLLINALL NSNNPVLRKK CRDLISNYVV EEAEN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [740-824]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKKLGELIGT VDVVYNKLNY ISDISLESTG LSKIVVTHGA LQRNLSLKEF VVLLEKPENG  60
   61 AHSICGIPIR DQSGNLNVCL HSYFD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [825-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASLGIALDG LDKPPTSYLL VHNEDFEKKW DVLMTSTFRN RTVPLNIIQY LISHTDSNTE  60
   61 FN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.09691
Match: 1dg3A_
Description: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [887-1219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RMLRSNFDDS LLLIEKCKKF IKTFVDVSCS VKDVDFGNGF NLRHLPLKFS DNMADNLESL  60
   61 YESVRKCSIE FSEKPTIIRL YHVSRQFPID NRDIIDGNNL DLLKELYQKS LTIPLKVSYW 120
  121 TKLTRKICRL EWLSVYEHIF IERCDIKNED PAKYSLPLLY SYFEFGLKYC DSEDIDKLGE 180
  181 VRKLILKYQD MMQKVRVFLK KDPPSKISLS DLEDVLLDIE EYRLPIQSSF FSELDYVIRE 240
  241 IENAKKMNDV NILYNTDNID KIDELIRKND PKFVKFANQF NGSRLDKRPL ASDNSGSVKA 300
  301 KQELKVFKLW NQHLDQIMQK NKFIEILPSI FRC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.30103
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [1220-1299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLKSDKYIP LESCSKRQTK YCFCRRVEEG TAMVECEICK EWYHVDCISN GELVPPDDPN  60
   61 VLFVCSICTP PCMAVDNIEG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.30103
Match: 1fp0A_
Description: Nuclear corepressor KAP-1 (TIF-1beta)
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1300-1411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTFELDDLKR ILVESLKLSL IPDPPILKNL FDVFAFALNF KNEMEKELFT NGYVNQLSST  60
   61 HKIKYYLRKL KGSQCGFTNL TDPLRKHCQV KDAEAIKWLT DNGRIIITGI PN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.373 0.952 cellular cell wall organization c.30.1 PreATP-grasp domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle