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View Structure Prediction Details

Protein: CEP3
Organism: Saccharomyces cerevisiae
Length: 608 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CEP3.

Description E-value Query
Range
Subject
Range
CEP3 - Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the cen...
CBF3B_YEAST - Centromere DNA-binding protein complex CBF3 subunit B OS=Saccharomyces cerevisiae (strain ATCC 20450...
0.0 [1..608] [1..608]
YAS8_SCHPO - Uncharacterized transcriptional regulatory protein C3H8.08c OS=Schizosaccharomyces pombe (strain 972...
SPAC3H8.08c - transcription factor
0.008 [9..38] [14..43]
gi|5059357 - gi|5059357|gb|AAD38984.1| unknown [Aspergillus niger]
0.008 [5..35] [8..38]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNRTTQLKS KHPCSVCTRR KVKCDRMIPC GNCRKRGQDS ECMKSTKLIT ASSSKEYLPD  60
   61 LLLFWQNYEY WITNIGLYKT K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.071898
Match: 2hapC_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.82809978070212 bayes_pls_golite062009
transcription regulator activity 2.56733746771213 bayes_pls_golite062009
DNA binding 2.39669003719518 bayes_pls_golite062009
nucleic acid binding 2.24073515120143 bayes_pls_golite062009
transcription factor activity 1.37656394138073 bayes_pls_golite062009
sequence-specific DNA binding 0.671744152078418 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.600827672357843 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.444119306269532 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [82-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRDLTRTPAN LDTDTEECMF WMNYLQKDQS FQLMNFAMEN LGALYFGSIG DISELYLRVE  60
   61 QYWDRRADKN HSVDGKYWDA LIWSVFTMCI YYMPVEKLAE IFSVYPLHEY LGSNKRLNWE 120
  121 DGMQLVMCQN FARCSLFQLK QCDFMAHPDI RLVQAYLILA TTTFPYDEPL LANSLLTQCI 180
  181 HTFKNFHVDD FRPLLNDDPV ESIAKVTLGR IFYRLCGCDY LQSGPRKPIA LHTEVSSLLQ 240
  241 HAAYLQDLPN VDVYREENST EVLYWKIISL DRDLDQYLNK SSKPPLKTLD AIRRELDIFQ 300
  301 YKVDSLEEDF RSNNSRFQKF IALFQISTVS WKLFKMYLIY YDTADSLLKV IHYSKVIISL 360
  361 IVNNFHAKSE FFNRHPMVMQ TITRVVSFIS FYQIFVESAA VKQLLVDLTE LTANLPTIFG 420
  421 SKLDKLVYLT ERLSKLKLLW DKVQLLDSGD SFYHPVFKIL QNDIKIIELK NDEMFSLIKG 480
  481 LGSLVPLNKL RQESLLEEED ENNTEPSDFR TIVEEFQSEY NISDILS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [194-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNKRLNWEDG MQLVMCQNFA RCSLFQLKQC DFMAHPDIRL VQAYLILATT TFPYDEPLLA  60
   61 NSLLTQCIHT FKNFHVDDFR PLLNDDPVES IAKVTLGRIF YRLCGCDYLQ SGPRKPIALH 120
  121 TEVSSLLQHA AYLQDLPNVD VYREENSTEV LYWKIISLDR DLDQYLNKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [363-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPPLKTLDA IRRELDIFQY KVDSLEEDFR SNNSRFQKFI ALFQISTVSW KLFKMYLIYY  60
   61 DTADSLLKVI HYSKVIISLI VNNFHAKSEF FNRHPMVMQT ITRVVSFISF YQIFVESAAV 120
  121 KQLLVDLTEL TANLPTIFGS KLDKLVYLTE RLSKLKLLWD KVQLLDSGDS FYHPVFKILQ 180
  181 NDIKIIELKN DEMFSLIKGL GSLVPLNKLR QESLLEEEDE NNTEPSDFRT IVEEFQSEYN 240
  241 ISDILS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle