YRC Public Data Repository - Protein Structure Prediction

Protein:	SRT1
Organism:	Saccharomyces cerevisiae
Length:	343 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRT1.

Description	E-value	Query Range	Subject Range
gi\|190408330 - gi\|190408330\|gb\|EDV11595.1\| hypothetical protein SCRG_01991 [Saccharomyces cerevisiae RM11-1a] SRT1 - Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as oppose... gi\|151946257 - gi\|151946257\|gb\|EDN64488.1\| cis-prenyltransferase [Saccharomyces cerevisiae YJM789] SRT1_YEAST - Dehydrodolichyl diphosphate syntase complex subunit SRT1 OS=Saccharomyces cerevisiae (strain ATCC 20...	0.0	[1..343]	[1..343]
DHDDS - dehydrodolichyl diphosphate synthase	7.0E-89	[38..322]	[2..269]
DHDDS_MOUSE - Dehydrodolichyl diphosphate syntase complex subunit Dhdds OS=Mus musculus GN=Dhdds PE=2 SV=1	1.0E-87	[38..322]	[2..269]
UPPS_PYRAB - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Pyrococc... UPPS_PYRAB - Undecaprenyl pyrophosphate synthase OS=Pyrococcus abyssi GN=uppS PE=3 SV=1	9.0E-87	[36..301]	[5..264]
UPPS_PYRHO - Undecaprenyl pyrophosphate synthase OS=Pyrococcus horikoshii GN=uppS PE=3 SV=1 UPPS_PYRHO - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Pyrococc...	7.0E-86	[35..301]	[4..264]
gi\|25314098 - pir\|\|AI2234 undecaprenyl pyrophosphate synthetase [imported] - Nostoc sp. (strain PCC 7120) ISPT2_NOSS1 - Isoprenyl transferase 2 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=uppS2 PE=3 SV=1	1.0E-85	[46..303]	[3..253]
UPPS_PYRFU - Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) OS=Pyrococc... UPPS_PYRFU - Undecaprenyl pyrophosphate synthase OS=Pyrococcus furiosus GN=uppS PE=3 SV=1	2.0E-85	[35..301]	[4..264]
gi\|170714048, gi... - gi\|170714048\|gb\|EDT26230.1\| undecaprenyl diphosphate synthase [Clostridium perfringens CPE str. F496... gi\|110676017, gi... - gi\|110801370\|ref\|YP_696383.1\| undecaprenyl diphosphate synthase [Clostridium perfringens ATCC 13124]... gi\|182380984, gi... - gi\|182380984\|gb\|EDT78463.1\| undecaprenyl diphosphate synthase [Clostridium perfringens NCTC 8239], g... ISPT_CLOPE - Isoprenyl transferase OS=Clostridium perfringens (strain 13 / Type A) GN=uppS PE=3 SV=1 gi\|169299227, gi... - gi\|169342721\|ref\|ZP_02863762.1\| undecaprenyl diphosphate synthase [Clostridium perfringens C str. JG... gi\|177907477, gi... - gi\|182627140\|ref\|ZP_02954855.1\| undecaprenyl diphosphate synthase [Clostridium perfringens D str. JG... gi\|110803535, gi... - gi\|110803535\|ref\|YP_698983.1\| undecaprenyl diphosphate synthase [Clostridium perfringens SM101], gi\|... gi\|168208113, gi... - gi\|170660606\|gb\|EDT13289.1\| undecaprenyl diphosphate synthase [Clostridium perfringens E str. JGS198... UPPS_CLOPE - Undecaprenyl pyrophosphate synthase OS=Clostridium perfringens GN=uppS PE=3 SV=1 gi\|170710581, gi... - gi\|170710581\|gb\|EDT22763.1\| undecaprenyl diphosphate synthase [Clostridium perfringens B str. ATCC 3...	3.0E-85	[61..303]	[18..253]
ISPT_SYNY3 - Isoprenyl transferase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=uppS PE=3 SV=1 UPPS_SYNY3 - Undecaprenyl pyrophosphate synthase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=upp... gi\|7447507 - pir\|\|S75982 hypothetical protein sll0506 - Synechocystis sp. (strain PCC 6803)	6.0E-84	[55..301]	[9..248]

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Predicted Domain #1

Region A:
Residues: [1-343]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMPSIIQIQ FVALKRLLVE TKEQMCFAVK SIFQRVFAWV MSLSLFSWFY VNLQNILIKA  60
   61 LRVGPVPEHV SFIMDGNRRY AKSRRLPVKK GHEAGGLTLL TLLYICKRLG VKCVSAYAFS 120
  121 IENFNRPKEE VDTLMNLFTV KLDEFAKRAK DYKDPLYGSK IRIVGDQSLL SPEMRKKIKK 180
  181 VEEITQDGDD FTLFICFPYT SRNDMLHTIR DSVEDHLENK SPRINIRKFT NKMYMGFHSN 240
  241 KCELLIRTSG HRRLSDYMLW QVHENATIEF SDTLWPNFSF FAMYLMILKW SFFSTIQKYN 300
  301 EKNHSLFEKI HESVPSIFKK KKTAMSLYNF PNPPISVSVT GDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	324.512579
Match:	1jp3A_
Description:	Undecaprenyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
prenyltransferase activity	4.40397054534951	bayes_pls_golite062009
di-trans,poly-cis-decaprenylcistransferase activity	3.07573514495519	bayes_pls_golite062009
dehydrodolichyl diphosphate synthase activity	2.65131914933987	bayes_pls_golite062009
transferase activity	1.42376896518855	bayes_pls_golite062009
binding	1.19249144486008	bayes_pls_golite062009
catalytic activity	0.878978773660153	bayes_pls_golite062009
protein binding	0.555364167462951	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	0.256467886977999	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: