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View Structure Prediction Details

Protein: STB4
Organism: Saccharomyces cerevisiae
Length: 949 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STB4.

Description E-value Query
Range
Subject
Range
STB4 - Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteri...
STB4_YEAST - Probable transcriptional regulatory protein STB4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...
0.0 [1..949] [1..949]
gi|168849 - gi|168849|gb|AAA33602.1| pathway-specific regulatory protein [Neurospora crassa]
1.0E-43 [36..335] [2..292]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-38 [33..314] [17..337]
gi|6901427 - gi|6901427|emb|CAB71797.1| pathway-specific nitrogen regulator [Tolypocladium inflatum]
5.0E-37 [38..325] [21..285]
gi|4165298 - gi|4165298|emb|CAA22853.1| SPAC1327.01c [Schizosaccharomyces pombe]
2.0E-35 [51..314] [1..305]
QUTA_EMENI - Quinic acid utilization activator - Emericella nidulans (Aspergillus nidulans)
8.0E-34 [36..332] [1..306]
XLNR_ASPNG - Transcriptional activator xlnR OS=Aspergillus niger GN=xlnR PE=4 SV=1
1.0E-32 [36..260] [1..220]

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Predicted Domain #1
Region A:
Residues: [1-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSINHEIYYI LVFEHRSVAI KLIIVVIVLL QFFLARSRQI DRTWAHTNRK ERFREMTAIG  60
   61 NTDDALD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [68-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSTAASKENG KGRLRVQKAC ELCKKRKVKC DGNNPCLNCS KHQKECRYDF KATNRKRRRR  60
   61 QVASAVRDVS KTYAETSESF PRDLLSKSNI IINAPSDGVS SSASNSPNPN SHYHHISSTL 120
  121 PFMSGRPNHT FHSGSNLNGE NNNNSFPEDH MAKLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 1pyiA_
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 1.82012686871762 bayes_pls_golite062009
DNA binding 1.78629392205727 bayes_pls_golite062009
binding 1.76935935681721 bayes_pls_golite062009
transcription regulator activity 1.70162817919532 bayes_pls_golite062009
transcription factor activity 0.606922041618269 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.160255273911114 bayes_pls_golite062009
sequence-specific DNA binding 0.0882387940255902 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [223-949]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQLSSKLGNT TKESSIRTTR TNASDVNANP TVVNMKNSQE DCDTNHRSAI CDSAEALHNN  60
   61 NINSKENKII NSQITNTVND HFESPWQTFS LDKYRFHRRY QNILPYYLGV SILKDLSPQT 120
  121 IEYAKLKRPR VQNYGWNLSG GHYLKYKGDF RSQEKNIRHE SKFFDFDDPV HLSLINKLLR 180
  181 YYFDEINPVF SIIHEATFWQ QYNNKFLRQG KQNNSSANLF TSMLYLILST TLRFREGHLD 240
  241 GQKGQGTYSN TSLNITFEEK SILIKKPSIE ENLFKYAYLI INTLTFEWES FELIQSWLLI 300
  301 TFYFRTCYRQ TACWNALSQA VNMCNGMSLY LNKFPEIHST YDESKAWHCF WCCFIMDKLI 360
  361 SFQMGRFYQL SLPASEMCEQ MNLVKSKKFL QEEDDWFHEE TFQMLDLSII VTQFLKRDAQ 420
  421 DLNLNETVQL RSQLGQWYDT FIVGSQTNAY DDNYRYFYQV QPFMTYLDIR LTFEVRQLFC 480
  481 LIAPSSTANN KSLEYVVDTE LLISHCQMAI ENLAEITRSN LFFVPWWLNL SQLFTVNLIC 540
  541 IIYLHAGIAV TQNKAIMQSC QEIWRTLECS KPKNRPSMLP ECLWCLKMLN HMFCIRLRDS 600
  601 ALQLEATLGT DHGDDTPNRN KFEQFKKVGD NDADVEVDAG EREENADERQ ENPHNNSKRV 660
  661 PLATRSHNTT NFDGSIAISP ESAVANLGTD TGLPSDVLDT VSKIGNSPNV FDDDLFSNLL 720
  721 WFDQNFA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [245-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASDVNANPTV VNMKNSQEDC DTNHRSAICD SAEALHNNNI NSKENKIINS QITNTVNDHF  60
   61 ESPWQTFSLD KYRFHRRYQN ILPYYLGVSI LKDLSPQTIE YAKLKRPRVQ NYGWNLSGGH 120
  121 YLKYK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.25
Match: 1pyiA
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.67816066599632 bayes_pls_golite062009
nucleic acid binding 1.62620944167363 bayes_pls_golite062009
DNA binding 1.56468711383438 bayes_pls_golite062009
transcription regulator activity 1.48580372603095 bayes_pls_golite062009
transcription factor activity 0.430971106781157 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [370-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDFRSQEKNI RHESKFFDFD DPVHLSLINK LLRYYFDEIN PVFSIIHEAT FWQQYNNKFL  60
   61 RQGKQNNSSA NLFTSMLYLI LSTTLRFREG H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [461-669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDGQKGQGTY SNTSLNITFE EKSILIKKPS IEENLFKYAY LIINTLTFEW ESFELIQSWL  60
   61 LITFYFRTCY RQTACWNALS QAVNMCNGMS LYLNKFPEIH STYDESKAWH CFWCCFIMDK 120
  121 LISFQMGRFY QLSLPASEMC EQMNLVKSKK FLQEEDDWFH EETFQMLDLS IIVTQFLKRD 180
  181 AQDLNLNETV QLRSQLGQWY DTFIVGSQT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [670-837]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAYDDNYRYF YQVQPFMTYL DIRLTFEVRQ LFCLIAPSST ANNKSLEYVV DTELLISHCQ  60
   61 MAIENLAEIT RSNLFFVPWW LNLSQLFTVN LICIIYLHAG IAVTQNKAIM QSCQEIWRTL 120
  121 ECSKPKNRPS MLPECLWCLK MLNHMFCIRL RDSALQLEAT LGTDHGDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [838-949]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPNRNKFEQF KKVGDNDADV EVDAGEREEN ADERQENPHN NSKRVPLATR SHNTTNFDGS  60
   61 IAISPESAVA NLGTDTGLPS DVLDTVSKIG NSPNVFDDDL FSNLLWFDQN FA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle