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View Structure Prediction Details

Protein: CLU1
Organism: Saccharomyces cerevisiae
Length: 1277 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLU1.

Description E-value Query
Range		 Subject
Range
CLU1 - eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in...
CLU_YEAST - Clustered mitochondria protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLU1 PE...
 0.0 [1..1258] [1..1258]
CG8443-PA - This gene is referred to in FlyBase by the symbol Dmel\CG8443 (CG8443, FBgn0034087). It is a protein...
 0.0 [2..1272] [94..1383]
KIAA0664 - KIAA0664
gi|162318882, gi... - gi|162318882|gb|AAI56941.1| KIAA0664 [synthetic construct], gi|162317964|gb|AAI56058.1| KIAA0664 [sy...
 0.0 [158..1272] [1..1082]
clu-1 - status:Confirmed UniProt:P34466 protein_id:CAA81605.1
 0.0 [2..1208] [5..1175]
gi|5103827, gi|2... - gi|5103827|gb|AAD39657.1|AC007591_22 ESTs gb|F20110 and gb|F20109 come from this gene. [Arabidopsis ...
 0.0 [9..1272] [28..1114]
IF3X_DICDI - Putative eukaryotic translation initiation factor 3 subunit - Dictyostelium discoideum (Slime mold)
 0.0 [3..1140] [15..1198]

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Predicted Domain #1
Region A:
Residues: [1-716] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKKEEVKN ATVKVTVKLP KEDNHSHNTK HLKKTQSSKN NDISFEIGKE SKIQTVLDVL  60
   61 AMIPSSKYLT NVGLKTIEGD SQLSDEMSIK EIVGEKSELK LQLILKPYSA REALKHVITV 120
  121 RDFIGFAQET SDGLSEFAIS TGSSFSSLPL GPIKERSKQE EKDEKSDPEE KKNTFKDVTD 180
  181 EEKLKFNEMV HEVFSSFKNS SINKLLTSES NIITPCVRSL SFAPYNPVPP FYRSKGHLFY 240
  241 LQIVTLEGES FYITAIPSGF YVNKSNSTKF DPSPKENTDE NAHSSLIYYS LFDLIASRSK 300
  301 KFISHVQAFE KKLSALDSTS YVRPSNTFLH KPWFVSSLPP NNPDYLRLQT AALDTTPERN 360
  361 FNDEFQAIKD LTTSTLQDRI EMERLFSKVV HEFSVTAASG AMSIFYSDFV AMNPESPTRD 420
  421 QIFLKDNIFY SYVSDVSGNY EGKGGDEAAI AASNQDLKTI NILNRLHMHE VRYLLTTVVE 480
  481 FAGRRILAQT PVPGLLATMG NKIVKDANTG EEVTEDFVND INVKYGLDEG LGKIVYDADF 540
  541 DSVLEKKFVK AFHLKKHKVN GTELAFSSQS KGIVGFDKRR YILDLANTYP LDINFARQNF 600
  601 DNIEETGNRY PHRQTLLRPE LVEKWWNNKV EKEGVEFEKA YEENLFSYNP DAYQVEGIED 660
  661 ANVDEMSNYL QKEVIPSVIQ DYLSGNLSTP YNGEHLADTL HKNGINMRYL GKIIEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [717-802] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQKELDSQIV HYEQNLKAVE QDNKEYEDWE KSYLQKIENM IKERQAKINK LVQEGKEVPK  60
   61 ELTEDLKLND EEIKKPTDGK PVVVAY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.600 a.4.5 "Winged helix" DNA-binding domain
View Download 0.587 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.680 a.47.2 t-snare proteins
View Download 0.665 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.636 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.575 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.565 a.24.1 Apolipoprotein
View Download 0.565 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.558 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.544 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.535 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.516 a.47.2 t-snare proteins
View Download 0.503 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.467 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.467 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.430 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.429 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.428 a.47.2 t-snare proteins
View Download 0.428 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.427 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.422 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.399 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.395 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.380 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.374 a.28.2 Colicin E immunity proteins
View Download 0.363 f.15.1 Small-conductance potassium channel
View Download 0.361 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.354 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.349 a.2.7 tRNA-binding arm
View Download 0.348 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.334 a.64.1 Saposin
View Download 0.334 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.329 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.325 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.320 a.4.5 "Winged helix" DNA-binding domain
View Download 0.320 a.47.2 t-snare proteins
View Download 0.314 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.308 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.308 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.304 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.302 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.300 f.15.1 Small-conductance potassium channel
View Download 0.298 a.4.3 ARID-like
View Download 0.297 a.83.1 Guanido kinase N-terminal domain
View Download 0.282 a.47.2 t-snare proteins
View Download 0.278 a.7.8 GAT domain
View Download 0.277 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.273 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.271 a.17.1 p8-MTCP1
View Download 0.271 a.7.7 BAG domain
View Download 0.271 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.268 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.266 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.264 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.261 a.2.7 tRNA-binding arm
View Download 0.259 a.135.1 Tetraspanin
View Download 0.250 a.24.15 FAD-dependent thiol oxidase
View Download 0.250 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.250 a.135.1 Tetraspanin
View Download 0.248 a.47.2 t-snare proteins
View Download 0.247 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.246 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.246 a.60.8 HRDC-like
View Download 0.245 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.243 a.4.5 "Winged helix" DNA-binding domain
View Download 0.239 a.25.1 Ferritin-like
View Download 0.238 a.2.7 tRNA-binding arm
View Download 0.237 d.8.1 Urease, gamma-subunit
View Download 0.237 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.236 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.233 d.53.1 Ribosomal protein S3 C-terminal domain
View Download 0.229 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.229 a.36.1 Signal peptide-binding domain
View Download 0.226 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.225 a.24.9 alpha-catenin/vinculin
View Download 0.224 a.7.7 BAG domain
View Download 0.222 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.222 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.220 d.34.1 DNA-binding domain of Mlu1-box binding protein MBP1
View Download 0.216 a.25.1 Ferritin-like
View Download 0.212 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.212 a.7.5 Tubulin chaperone cofactor A
View Download 0.211 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.204 a.16.1 S15/NS1 RNA-binding domain
View Download 0.204 a.118.1 ARM repeat
View Download 0.204 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.204 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.203 a.24.17 Group V grass pollen allergen
View Download 0.203 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.203 a.47.2 t-snare proteins
View Download 0.201 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.200 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.200 f.15.1 Small-conductance potassium channel

Predicted functions:

Term Confidence Notes
binding 1.58148987937399 bayes_pls_golite062009
protein binding 0.856276659140234 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [803-991] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELVPLIKIS ELEIVSRSLK HVLKDLSKDV PVFLVPSLVA YVFNMLVGIN YNADPKPEPV  60
   61 DEFYPVNKCS FAKLTRSELL EAVSKQAFLR FRHQLPSNWI EAYMENPFTL IRSVSYKFGI 120
  121 QLLNKEYFFT REQLESYKQS LDKKIRNKFV EPPTTFSLSD LTIIPRVKFS EYTSSVSEEF 180
  181 WAQGASMIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [992-1076] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDKQSALTLL AQSITVLEDV NNILHPAVAE KYLSLSAIYN KLALYPEAIA FCRKACTIYE  60
   61 RVSGIDSFEM MRALTNLAIL EFSNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1077-1154] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPYNATVVYN RLAEILKVYE LPKIHHPAPT SIFNHLEQLA LGVQDTKLAI EVLGQLSSYV  60
   61 VELEGKDSLA YGYTESRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.07985546140154 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
transcription regulator activity 0.921062221092247 bayes_pls_golite062009
nucleic acid binding 0.75712113503301 bayes_pls_golite062009
DNA binding 0.665813461397509 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1155-1277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNLFAALKDF HRALEHITVT QGIFTKQLGM NHTHSAQSRQ WVNGLSSLIM DLKQKKQLAQ  60
   61 DQMSTTGSNS AGHKKTNHRQ KKDDVKPELA NKSVDELLTF IEGDSSNSKS KNKTNNKKKH 120
  121 GKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle