YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC65
Organism:	Saccharomyces cerevisiae
Length:	273 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC65.

Description	E-value	Query Range	Subject Range
gi\|190408142 - gi\|190408142\|gb\|EDV11407.1\| signal recognition particle SEC65 subunit [Saccharomyces cerevisiae RM11... gi\|207342603 - gi\|207342603\|gb\|EDZ70323.1\| YML105Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151946058 - gi\|151946058\|gb\|EDN64289.1\| secretory subuint [Saccharomyces cerevisiae YJM789] SEC65 - Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts... SEC65_YEAST - Signal recognition particle subunit SEC65 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...	8.0E-91	[1..273]	[1..273]
SEC65_CANAX - Signal recognition particle SEC65 subunit OS=Candida albicans GN=SEC65 PE=3 SV=1	3.0E-67	[2..272]	[7..272]
SC65_YARLI, SEC6... - Signal recognition particle SEC65 subunit OS=Yarrowia lipolytica GN=SEC65 PE=3 SV=1, (P41922) Signal... SEC65_YARLI - Signal recognition particle SEC65 subunit OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SEC65 ...	1.0E-66	[1..272]	[1..310]
gi\|28916785, gi\|... - gi\|32404260\|ref\|XP_322743.1\| hypothetical protein [Neurospora crassa], gi\|28916785\|gb\|EAA26541.1\| co... gi\|85075489 - gi\|85075489\|ref\|XP_955777.1\| hypothetical protein NCU03485 [Neurospora crassa OR74A]	3.0E-64	[2..247]	[5..280]
SEC65_KLULA - Signal recognition particle SEC65 subunit OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM... SC65_KLULA, SEC6... - Signal recognition particle SEC65 subunit OS=Kluyveromyces lactis GN=SEC65 PE=3 SV=2, (O13475) Signa...	5.0E-58	[98..273]	[2..181]
sec65 - signal recognition particle subunit Sec65 SEC65_SCHPO - Signal recognition particle sec65 subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...	2.0E-39	[99..251]	[4..144]
gi\|8778511 - gi\|8778511\|gb\|AAF79519.1\|AC023673_7 F21D18.11 [Arabidopsis thaliana]	2.0E-35	[95..193]	[8..107]
gi\|12846431 - gi\|12846431\|dbj\|BAB27165.1\| unnamed protein product [Mus musculus]	9.0E-32	[88..199]	[5..118]

Back

Predicted Domain #1

Region A:
Residues: [1-81]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRLEEIDDF NDIDDLDMEL AELDPSLRTP IAPKITPKVV RSQDQENPAF LPGTNNNSNS  60
   61 NNNSSNEKEQ LSFINPKTGK V

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [82-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERSEAISKKD LEEVKRFQVL YPCYFDINRS HKEGRRVPKE LAVENPLAKT MADAVRELGI  60
   61 LCIFEGEKCH PQDFGNPGRI RVLFKENGQL IGAATKFKGG KRQLMKAVGE YMKRHPTTI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.512579
Match:	1jidA_
Description:	SRP19
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
7S RNA binding	9.78481287368136	bayes_pls_golite062009
binding	1.18350763063367	bayes_pls_golite062009
RNA binding	0.908575257318977	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [201-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESLREIPYGP DFDNIEFKKI PRVKGFKMNE IVPLHSPFLM GHPMTKSVYE TPKITAAEKS  60
   61 FKPPKNKYKV VRR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: