YRC Public Data Repository - Protein Structure Prediction

Protein:	ERG6
Organism:	Saccharomyces cerevisiae
Length:	383 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG6.

Description	E-value	Query Range	Subject Range
ERG6_YEAST - Sterol 24-C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG6 PE=1 ... gi\|151946153 - gi\|151946153\|gb\|EDN64384.1\| delta(24)-sterol C-methyltransferase [Saccharomyces cerevisiae YJM789] ERG6 - Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthet...	0.0	[1..383]	[1..383]
ERG6_PNECA - Sterol 24-C-methyltransferase OS=Pneumocystis carinii GN=erg6 PE=2 SV=1	7.0E-95	[3..369]	[6..376]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-89	[3..370]	[8..379]
gi\|3560474 - gi\|3560474\|gb\|AAC34951.1\| S-adenosyl-methionine-sterol-C- methyltransferase [Nicotiana tabacum]	2.0E-89	[20..370]	[5..343]
ERG6_SCHPO - Sterol 24-C-methyltransferase erg6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg6 PE... erg6 - delta-sterol C-methyltransferase	2.0E-88	[10..369]	[12..375]
ERG6_CANAL - Sterol 24-C-methyltransferase OS=Candida albicans GN=ERG6 PE=3 SV=1 ERG6_CANAL - Sterol 24-C-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG6 PE=3 SV=1	2.0E-88	[1..369]	[6..372]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETELRKRQ AQFTRELHGD DIGKKTGLSA LMSKNNSAQK EAVQKYLRNW DGRTDKDAEE  60
   61 RRLEDYNEAT HSYYNVVTDF YE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [229-248]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKYDENNPEH RKIAYEIELG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [295-334]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYVQNLANLA TFFRTSYLGR QFTTAMVTVM EKLGLAPEGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.30103
Match:	1kp9A_
Description:	CmaA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25333584501255	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
binding	0.422181371325275	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.181420092548185	bayes_pls_golite062009
DNA binding	0.00720144044916005	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [83-228]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGWGSSFHFS RFYKGESFAA SIARHEHYLA YKAGIQRGDL VLDVGCGVGG PAREIARFTG  60
   61 CNVIGLNNND YQIAKAKYYA KKYNLSDQMD FVKGDFMKMD FEENTFDKVY AIEATCHAPK 120
  121 LEGVYSEIYK VLKPGGTFAV YEWVMT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [249-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGIPKMFHVD VARKALKNCG FEVLVSEDLA DNDDEIPWYY PLTGEW

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [335-383]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEVTAALENA AVGLVAGGKS KLFTPMMLFV ARKPENAETP SQTSQEATQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.30103
Match:	1kp9A_
Description:	CmaA1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: