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View Structure Prediction Details

Protein: TRM12
Organism: Saccharomyces cerevisiae
Length: 462 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM12.

Description E-value Query
Range		 Subject
Range
TYW2_YEAST - tRNA wybutosine-synthesizing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=T...
gi|151946157 - gi|151946157|gb|EDN64388.1| tRNA methyltransferase [Saccharomyces cerevisiae YJM789]
TRM12 - S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybut...
 0.0 [1..462] [1..462]
TYW23_ARATH - tRNA wybutosine-synthesizing protein 2/3/4 OS=Arabidopsis thaliana GN=At4g04670 PE=2 SV=1
 6.0E-61 [37..457] [663..993]
TRM5_MACFA - tRNA (guanine(37)-N1)-methyltransferase OS=Macaca fascicularis GN=TRMT5 PE=2 SV=1
 3.0E-53 [64..461] [81..471]
gi|7243167 - gi|7243167|dbj|BAA92631.1| KIAA1393 protein [Homo sapiens]
 2.0E-51 [64..461] [72..462]
TRM5_MOUSE - tRNA (guanine(37)-N1)-methyltransferase OS=Mus musculus GN=Trmt5 PE=1 SV=1
 6.0E-51 [64..462] [74..465]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-40 [73..459] [61..466]
ANM3_RAT - Protein arginine N-methyltransferase 3 OS=Rattus norvegicus GN=Prmt3 PE=1 SV=1
 3.0E-36 [84..421] [95..393]

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Predicted Domain #1
Region A:
Residues: [1-226] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDETMPVEF LVSDKRLLKT IKVKLETNGL FVTPIYSDND NKVIKSSIED LNHPLAVEIN  60
   61 NIAGVKARFH ESGNLERSEG HLKHQSNSIT EFTKSFLKDH GLANDKIFLS HLLDHLPLKY 120
  121 TIYPPVVLFN NSTVRSFNHP IWQKAFQLKL FDPNEYYREL LCFLSPGKPS KGTSLHPNNR 180
  181 LLTHLAINNP ITEADVLRRP FNIQPLYGKL IDDSILDDND NTLWEN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [227-462] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQEQLNSSI WCKVIQNGVT QIWSPVFTMF SRGNIKEKKR VLTTFPDICN NDVVDLYAGI  60
   61 GYFTFSYLTK GARTLFAFEL NPWSVEGLKR GLKANGFNKS GNCHVFQESN EMCVQRLTEF 120
  121 LSQNPGFRLR IRHINLGLLP SSKQGWPLAI KLIYLQGASL EKVTMHIHEN VHIDAIEDGS 180
  181 FEKNVIVELD AINESIALIR NRGIKLQFVR SKLERIKTFA PDIWHVCVDV DVIVST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.221849
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
rRNA methyltransferase activity 2.29640050660273 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.533090627724779 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.455449410561251 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.364369105571521 bayes_pls_golite062009
hydrolase activity 0.33020971648583 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle