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View Structure Prediction Details

Protein: GLO1
Organism: Saccharomyces cerevisiae
Length: 326 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLO1.

Description E-value Query
Range
Subject
Range
gi|190408236 - gi|190408236|gb|EDV11501.1| lactoylglutathione lyase [Saccharomyces cerevisiae RM11-1a]
gi|11182130 - gi|11182130|emb|CAC16163.1| glyoxalase I [Saccharomyces cerevisiae]
gi|207342459 - gi|207342459|gb|EDZ70220.1| YML004Cp-like protein [Saccharomyces cerevisiae AWRI1631]
4.0E-74 [1..326] [1..326]
glo1 - glyoxalase I
LGUL_SCHPO - Lactoylglutathione lyase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=glo1 PE=1 SV=1
5.0E-54 [20..323] [9..302]
LGUC_ARATH - Probable lactoylglutathione lyase, chloroplastic OS=Arabidopsis thaliana GN=At1g67280 PE=1 SV=1
6.0E-48 [17..316] [83..336]
gi|125560421 - gi|125560421|gb|EAZ05869.1| hypothetical protein OsI_28106 [Oryza sativa Indica Group]
LGUL_ORYSA - Lactoylglutathione lyase (EC 4.4.1.5) (Methylglyoxalase) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ke...
LGUL_ORYSJ - Lactoylglutathione lyase OS=Oryza sativa subsp. japonica GN=GLX-I PE=1 SV=2
1.0E-45 [16..324] [18..285]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-44 [17..326] [17..280]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTDSTRYPI QIEKASNDPT LLLNHTCLRV KDPARTVKFY TEHFGMKLLS RKDFEEAKFS  60
   61 LYFLSFPKDD IPKNKNGEPD VFSAHGVLEL THNWGTEKNP DYKINNGNEE P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 360.9897
Match: 1froA_
Description: Glyoxalase I (lactoylglutathione lyase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lactoylglutathione lyase activity 3.91334658149719 bayes_pls_golite062009
binding 1.68530537296561 bayes_pls_golite062009
carbon-sulfur lyase activity 1.44168339433372 bayes_pls_golite062009
catalytic activity 1.21778090213032 bayes_pls_golite062009
protein binding 0.28912087714501 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 0.0991913830827656 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-176]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRGFGHICFS VSDINKTCEE LESQGVKFKK RLSEGRQKDI AFALGPDGYW IELITYSREG  60
   61 QEYPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 360.9897
Match: 1froA_
Description: Glyoxalase I (lactoylglutathione lyase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lactoylglutathione lyase activity 3.91334658149719 bayes_pls_golite062009
binding 1.68530537296561 bayes_pls_golite062009
carbon-sulfur lyase activity 1.44168339433372 bayes_pls_golite062009
catalytic activity 1.21778090213032 bayes_pls_golite062009
protein binding 0.28912087714501 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 0.0991913830827656 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [177-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSVGNKFNHT MIRIKNPTRS LEFYQNVLGM KLLRTSEHES AKFTLYFLGY GVPKTDSVFS  60
   61 CESVLELTHN WGTENDPNFH YHNGNSEPQG YGHICISCDD AGALCKEIEV KYGDKIQWSP 120
  121 KFNQGRMKNI AFLKDPDGYS IEVVPHGLIA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1jc5A_
Description: Methylmalonyl-CoA epimerase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle