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View Structure Prediction Details

Protein: REH1
Organism: Saccharomyces cerevisiae
Length: 432 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for REH1.

Description E-value Query
Range
Subject
Range
gi|2224593 - gi|2224593|dbj|BAA20784.1| KIAA0326 [Homo sapiens]
0.0 [3..360] [205..590]
Z287_MOUSE, ZN28... - Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=1, (Q9EQB9) Zinc finger protein 287 (Zfp-2...
0.0 [3..362] [391..750]
ZN252_CANLF - Zinc finger protein 252 OS=Canis lupus familiaris GN=ZNF252 PE=2 SV=1
0.0 [2..362] [396..812]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTFFTCNC CVIQFKTSDL QRYHMKTEWH RYNLKRRIAN LPPIGAEQFA EKLQISEKEQ  60
   61 AENQVDEFGF PVLKPVMNQS NALPQKQKKP IKSKRG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.0
Match: 1meyG_
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [97-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKVGTNLLKR KDRDIAKEKQ NRSVSPSGSI SSQLSNLTVG TENTNTDYGE DTVSEYGFTS  60
   61 DSNYEYATSD EELDIADKPS DKENEKITIT ECIYCGKDNK EVERNVKHMF SEHGLFIPER 120
  121 SYLIDLNGLL EFLIKMIVID HNCLCCNFHG SGLESIRAHM ASKRHCRLPY ETKEERQLFA 180
  181 PFYDFTYDDH SIS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.36961042761402 bayes_pls_golite062009
DNA binding 1.83298509797997 bayes_pls_golite062009
nucleic acid binding 1.81905872620454 bayes_pls_golite062009
transcription regulator activity 1.79634171647159 bayes_pls_golite062009
RNA binding 1.69160965456631 bayes_pls_golite062009
transcription factor activity 0.972881822816115 bayes_pls_golite062009
transcription activator activity 0.953363449552372 bayes_pls_golite062009
protein binding 0.852654490075478 bayes_pls_golite062009
sequence-specific DNA binding 0.246568450747506 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.095249486073484 bayes_pls_golite062009
chromatin binding 0.0383915131562336 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [290-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNLQNDRAIT SKLSSVYGAK NDEEDGEVDI TLVSSENDIN ANYTTVSIDE SGLELTLPTG  60
   61 ARLGHRAGQR YYRQNLPSQP NPNESRRTIT AADRRMVSGV TEKQYKKGMK KMQQLEKNAI 120
  121 NTQIRREIKR VNFQTHYRDE LLQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle