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View Structure Prediction Details

Protein: VAC14
Organism: Saccharomyces cerevisiae
Length: 880 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VAC14.

Description E-value Query
Range
Subject
Range
VAC14 - Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some protei...
VAC14_YEAST - Vacuole morphology and inheritance protein 14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
0.0 [1..880] [1..880]
VAC14_SCHPO - Protein VAC14 homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC25H2.03 PE=3 SV=...
SPBC25H2.03 - vacuolar protein involved in phosphoinositide metabolism
0.0 [1..799] [1..740]
CE06100 - status:Partially_confirmed UniProt:Q21225 protein_id:CAB00043.1
0.0 [1..797] [9..665]
gi|10438006, gi|... - gb|AAH07214.1| FLJ10305 protein [Homo sapiens], gi|10438006|dbj|BAB15145.1| unnamed protein product ...
0.0 [393..801] [1..503]
VAC14_ARATH - Protein VAC14 homolog OS=Arabidopsis thaliana GN=VAC14 PE=1 SV=2
0.0 [144..800] [25..666]
gi|17944590 - gi|17944590|gb|AAL48182.1| SD04925p [Drosophila melanogaster]
0.0 [1..449] [8..406]

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Predicted Domain #1
Region A:
Residues: [1-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKSIAKGLS DKLYEKRKAA ALELEKLVKQ CVLEGDYDRI DKIIDELCRD YAYALHQPMA  60
   61 RNAGLMGLAA TAIALGINDV GRYLRNILPP VLACFGDQND QVRFYACESL YNIAKIAKGE 120
  121 ILVYFNEIFD VLCKISADTE NSVRGAAELL DRLIKDIVAE RASNYISIVN NGSHGLLPAI 180
  181 KTDPISGDVY QEEYEQDNQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.835 0.070 vacuole inheritance a.118.1 ARM repeat
View Download 0.571 0.070 vacuole inheritance a.87.1 DBL homology domain (DH-domain)
View Download 0.881 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.559 0.070 vacuole inheritance f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.551 0.070 vacuole inheritance a.118.1 ARM repeat
View Download 0.527 0.070 vacuole inheritance a.118.1 ARM repeat
View Download 0.504 0.070 vacuole inheritance f.18.1 F1F0 ATP synthase subunit A
View Download 0.491 0.070 vacuole inheritance a.118.9 ENTH/VHS domain
View Download 0.466 0.070 vacuole inheritance a.146.1 Telomeric repeat binding factor (TRF) dimerisation domain
View Download 0.465 0.070 vacuole inheritance a.172.1 Helical scaffold and wing domains of SecA
View Download 0.465 0.070 vacuole inheritance a.25.1 Ferritin-like
View Download 0.446 0.070 vacuole inheritance a.95.1 Influenza virus matrix protein M1
View Download 0.444 0.070 vacuole inheritance a.24.1 Apolipoprotein
View Download 0.418 0.070 vacuole inheritance f.13.1 Family A G protein-coupled receptor-like
View Download 0.400 0.070 vacuole inheritance f.13.1 Family A G protein-coupled receptor-like
View Download 0.395 0.070 vacuole inheritance f.13.1 Family A G protein-coupled receptor-like
View Download 0.383 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.372 0.070 vacuole inheritance a.118.9 ENTH/VHS domain
View Download 0.371 0.070 vacuole inheritance a.118.1 ARM repeat
View Download 0.367 0.070 vacuole inheritance c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.364 0.070 vacuole inheritance c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.364 0.070 vacuole inheritance a.118.9 ENTH/VHS domain
View Download 0.361 0.070 vacuole inheritance d.210.1 Argininosuccinate synthetase, C-terminal domain
View Download 0.361 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.358 0.070 vacuole inheritance c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.357 0.070 vacuole inheritance f.18.1 F1F0 ATP synthase subunit A
View Download 0.349 0.070 vacuole inheritance a.24.9 alpha-catenin/vinculin
View Download 0.344 0.070 vacuole inheritance a.118.9 ENTH/VHS domain
View Download 0.337 0.070 vacuole inheritance a.1.1 Globin-like
View Download 0.323 0.070 vacuole inheritance a.118.10 Phosphoinositide-binding clathrin adaptor, N-terminal domain
View Download 0.305 0.070 vacuole inheritance a.146.1 Telomeric repeat binding factor (TRF) dimerisation domain
View Download 0.304 0.070 vacuole inheritance c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.302 0.070 vacuole inheritance a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.289 0.070 vacuole inheritance a.87.1 DBL homology domain (DH-domain)
View Download 0.289 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.287 0.070 vacuole inheritance a.118.9 ENTH/VHS domain
View Download 0.280 0.070 vacuole inheritance a.25.1 Ferritin-like
View Download 0.269 0.070 vacuole inheritance d.90.1 NADH oxidase/flavin reductase
View Download 0.267 0.070 vacuole inheritance a.118.1 ARM repeat
View Download 0.266 0.070 vacuole inheritance f.18.1 F1F0 ATP synthase subunit A
View Download 0.262 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.259 0.070 vacuole inheritance a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.257 0.070 vacuole inheritance e.6.1 Acyl-CoA dehydrogenase NM domain-like
View Download 0.254 0.070 vacuole inheritance a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.254 0.070 vacuole inheritance d.173.1 Methionine synthase activation domain-like
View Download 0.251 0.070 vacuole inheritance c.6.1 Cellulases
View Download 0.250 0.070 vacuole inheritance c.108.1 HAD-like
View Download 0.242 0.070 vacuole inheritance a.146.1 Telomeric repeat binding factor (TRF) dimerisation domain
View Download 0.242 0.070 vacuole inheritance a.24.9 alpha-catenin/vinculin
View Download 0.242 0.070 vacuole inheritance f.1.1 Colicin
View Download 0.240 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.240 0.070 vacuole inheritance a.172.1 Helical scaffold and wing domains of SecA
View Download 0.239 0.070 vacuole inheritance d.67.3 Ribosome recycling factor, RRF
View Download 0.237 0.070 vacuole inheritance a.138.1 Multiheme cytochromes
View Download 0.235 0.070 vacuole inheritance d.173.1 Methionine synthase activation domain-like
View Download 0.232 0.070 vacuole inheritance d.67.3 Ribosome recycling factor, RRF
View Download 0.230 0.070 vacuole inheritance a.146.1 Telomeric repeat binding factor (TRF) dimerisation domain
View Download 0.225 0.070 vacuole inheritance a.102.5 Family 10 polysaccharide lyase
View Download 0.223 0.070 vacuole inheritance a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.223 0.070 vacuole inheritance a.63.1 Apolipophorin-III
View Download 0.221 0.070 vacuole inheritance a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.220 0.070 vacuole inheritance a.26.1 4-helical cytokines
View Download 0.217 0.070 vacuole inheritance d.110.2 GAF domain-like
View Download 0.215 0.070 vacuole inheritance a.24.1 Apolipoprotein
View Download 0.211 0.070 vacuole inheritance c.101.1 Undecaprenyl diphosphate synthase
View Download 0.208 0.070 vacuole inheritance c.80.1 SIS domain
View Download 0.207 0.070 vacuole inheritance c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.207 0.070 vacuole inheritance d.153.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View Download 0.207 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.206 0.070 vacuole inheritance a.118.9 ENTH/VHS domain
View Download 0.206 0.070 vacuole inheritance a.118.8 TPR-like
View Download 0.203 0.070 vacuole inheritance c.108.1 HAD-like
View Download 0.203 0.070 vacuole inheritance c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.200 0.070 vacuole inheritance f.25.1 Cytochrome c oxidase subunit III-like

Predicted Domain #2
Region A:
Residues: [200-653]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAFSLPKFIP LLTERIYAIN PDTRVFLVDW LKVLLNTPGL ELISYLPSFL GGLFTFLGDS  60
   61 HKDVRTVTHT LMDSLLHEVD RISKLQTEIK MKRLERLKML EDKYNNSSTP TKKADGALIA 120
  121 EKKKTLMTAL GGLSKPLSME TDDTKLSNTN ETDDERHLTS QEQLLDSEAT SQEPLRDGEE 180
  181 YIPGQDINLN FPEVITVLVN NLASSEAEIQ LIALHWIQVI LSISPNVFIP FLSKILSVLL 240
  241 KLLSDSDPHI TEIAQLVNGQ LLSLCSSYVG KETDGKIAYG PIVNSLTLQF FDSRIDAKIA 300
  301 CLDWLILIYH KAPNQILKHN DSMFLTLLKS LSNRDSVLIE KALSLLQSLC SDSNDNYLRQ 360
  361 FLQDLLTLFK RDTKLVKTRA NFIMRQISSR LSPERVYKVI SSILDNYNDT TFVKMMIQIL 420
  421 STNLITSPEM SSLRNKLRTC EDGMFFNSLF KSWC

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.67
Match: 1b89A
Description: Clathrin heavy chain proximal leg segment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [654-880]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPVSVISLC FVAENYELAY TVLQTYANYE LKLNDLVQLD ILIQLFESPV FTRMRLQLLE  60
   61 QQKHPFLHKC LFGILMIIPQ SKAFETLNRR LNSLNIWTSQ SYVMNNYIRQ RENSNFCDSN 120
  121 SDISQRSVSQ SKLHFQELIN HFKAVSEEDE YSSDMIRLDH GANNKSLLLG SFLDGIDEDK 180
  181 QEIVTPISPM NEAINEEMES PNDNSSVILK DSGSLPFNRN VSDKLKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.53151481871847 bayes_pls_golite062009
nucleic acid binding 1.70854853801477 bayes_pls_golite062009
protein binding 1.61131270705552 bayes_pls_golite062009
transcription regulator activity 1.1879835276438 bayes_pls_golite062009
DNA binding 1.03880684185645 bayes_pls_golite062009
signal transducer activity 0.862740830365635 bayes_pls_golite062009
molecular transducer activity 0.862740830365635 bayes_pls_golite062009
structural molecule activity 0.851103372489505 bayes_pls_golite062009
translation regulator activity 0.642878560112121 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.620348955429476 bayes_pls_golite062009
transcription factor activity 0.389120912139882 bayes_pls_golite062009
translation initiation factor activity 0.286790642914928 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [787-880]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HFQELINHFK AVSEEDEYSS DMIRLDHGAN NKSLLLGSFL DGIDEDKQEI VTPISPMNEA  60
   61 INEEMESPND NSSVILKDSG SLPFNRNVSD KLKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle