YRC Public Data Repository - Protein Structure Prediction

Protein:	ILV5
Organism:	Saccharomyces cerevisiae
Length:	395 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ILV5.

Description	E-value	Query Range	Subject Range
ILV5 - Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosy... gi\|151940879 - gi\|151940879\|gb\|EDN59261.1\| acetohydroxyacid reductoisomerase [Saccharomyces cerevisiae YJM789] ILV5_YEAST - Ketol-acid reductoisomerase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ... gi\|190405401 - gi\|190405401\|gb\|EDV08668.1\| cetohydroxyacid reductoisomerase [Saccharomyces cerevisiae RM11-1a]	0.0	[1..395]	[1..395]
ILVC_RHIME - Ketol-acid reductoisomerase OS=Rhizobium meliloti (strain 1021) GN=ilvC PE=3 SV=2 ILVC_RHIME - Ketol-acid reductoisomerase OS=Rhizobium meliloti GN=ilvC PE=3 SV=2	0.0	[63..392]	[2..326]
ILVC_ZYMMO - Ketol-acid reductoisomerase OS=Zymomonas mobilis GN=ilvC PE=3 SV=1 gi\|241373456, gi... - gi\|241761990\|ref\|ZP_04760074.1\| ketol-acid reductoisomerase [Zymomonas mobilis subsp. mobilis ATCC 1... ILVC_ZYMMO - Ketol-acid reductoisomerase OS=Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) GN=i...	0.0	[63..392]	[2..326]
ILVC_RHILO - Ketol-acid reductoisomerase OS=Rhizobium loti (strain MAFF303099) GN=ilvC PE=3 SV=1 ILVC_RHILO - Ketol-acid reductoisomerase OS=Rhizobium loti GN=ilvC PE=3 SV=1	0.0	[63..392]	[2..326]
ILVC_PHAMO - Ketol-acid reductoisomerase OS=Phaeospirillum molischianum GN=ilvC PE=3 SV=1	0.0	[63..392]	[2..326]
gi\|25283861, gi\|... - gi\|25283861\|pir\|\|AE2824 ketol-acid reductoisomerase [imported] - Agrobacterium tumefaciens (strain C... ILVC_AGRFC - Ketol-acid reductoisomerase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=ilvC PE=3 SV=1	0.0	[63..392]	[2..326]
gi\|107103793 - gi\|107103793\|ref\|ZP_01367711.1\| hypothetical protein PaerPA_01004864 [Pseudomonas aeruginosa PACS2] gi\|254238566, gi... - gi\|84317328\|ref\|ZP_00965777.1\| COG0059: Ketol-acid reductoisomerase [Pseudomonas aeruginosa C3719], ... ILVC_PSEAE - Ketol-acid reductoisomerase OS=Pseudomonas aeruginosa GN=ilvC PE=1 SV=1 ILVC_PSEAB - Ketol-acid reductoisomerase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=ilvC PE=3 SV=1 ILVC_PSEAE - Ketol-acid reductoisomerase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG... ILVC_PSEA8 - Ketol-acid reductoisomerase OS=Pseudomonas aeruginosa (strain LESB58) GN=ilvC PE=3 SV=1	0.0	[63..392]	[2..325]
ILVC_RALSO - Ketol-acid reductoisomerase OS=Ralstonia solanacearum (strain GMI1000) GN=ilvC PE=3 SV=1 ILVC_RALSO - Ketol-acid reductoisomerase OS=Ralstonia solanacearum GN=ilvC PE=3 SV=1	0.0	[63..392]	[2..325]

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Predicted Domain #1

Region A:
Residues: [1-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTQAARLI CNSRVITAKR TFALATRAAA YSRPAARFVK PMITTRGLKQ INFGGTVETV  60
   61 YERADWPREK LLDYFKNDTF ALIGYGSQGY GQGLNLRDNG LNVIIGVRKD GASWKAAIED 120
  121 GWVPGKNLFT VEDAIKRGSY VMNLLSDAAQ SETWPAIKPL LTKGKTLYFS HGFSPVFKDL 180
  181 THVEPPKDLD VILVAPKGSG RTVRSLFKEG RGINSSYAVW NDVTGKAHEK AQALAVAIGS 240
  241 GYVYQTTFER EVNSDLYGER GCLMGGIHGM FLAQYDVLRE NGHSPSEAFN ETVEEATQSL 300
  301 YPLIGKYGMD YMYDACSTTA RRGALDWYPI FKNALKPVFQ DLYESTKNGT ETKRSLEFNS 360
  361 QPDYREKLEK ELDTIRNMEI WKVGKEVRKL RPENQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	448.211549
Match:	1qmgA_
Description:	Class II ketol-acid reductoisomerase; Class II ketol-acid reductoisomerase (KARI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
ketol-acid reductoisomerase activity	0.414784304540676	bayes_pls_golite062009
binding	0.405786564527334	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0992243118937675	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: