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View Structure Prediction Details

Protein: YLR278C
Organism: Saccharomyces cerevisiae
Length: 1341 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLR278C.

Description E-value Query
Range
Subject
Range
YLR278C - Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defe...
YL278_YEAST - Uncharacterized transcriptional regulatory protein YLR278C OS=Saccharomyces cerevisiae (strain ATCC ...
0.0 [1..1341] [1..1341]
gi|166488 - gi|166488|gb|AAA32686.1| regulatory protein
0.0 [38..748] [16..664]
UAY_EMENI - Positive regulator of purine utilization - Emericella nidulans (Aspergillus nidulans)
0.0 [35..761] [62..828]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [25..697] [23..630]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRPRKNVSQ EKIQQLKREL ELAGNRTDVL LQDKKGRSRS CLLCRRRKQR CDHKLPSCTA  60
   61 CLKAGIKCVQ PSKYSSSTSN SNTNNNTPTA GTVPPTPHPV IKRELQDSSI GAGAGAATSL 120
  121 NDMTIIKPIS TSNSNVDAGD ANEFRKTIKS VTTNSNPNLM RQDKDQYTIF LEKKLKSLET 180
  181 LLDLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.522879
Match: 1pyiA_
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.226078362275538 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [186-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGCNQYNYEL SQYKKVSHLF SNNTSDYSRP NSSNMVILPL PSPSNKPLEN TNNNGSNVNA  60
   61 ATNDTSASTN NINNNNAIC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 0.134879671454648 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [265-681]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSASLLNDPL ETLDFTKCIF AKYNLKKEFL MYDPIFELNE KLSRSFLDTF FTRLQFKYPI  60
   61 LDEQEIYTFY DHYLHNKILI PPSSPATSSA APPSNSHSYS EIEFHFLSGR MWLVFSISAY 120
  121 LLMTTGKYKG FPPHRYFSTA IRHITKCGLH LNYVQQIELL TLLVLYIIRT DRDSLILYDI 180
  181 IKDVMGISKK KLHLNQWYPN DPFANKKLRL FWCVYLLERM ICVAVGKPYT IKESEINLPL 240
  241 FNNDSFYTKG VHAAAPSTND HGVQFINQSL KLRRIESQFV ETLQLLKNDS RSVKQSIDQL 300
  301 PLVRKFFEDL EVWRKSYSTL DVKNFENETL KLYYYRSVRL LIQPYLEFFA PEDRLFRECQ 360
  361 AAAGQICQLY KIFHQKTLNG HSTPAVHTVF VAGVTLIYCM WLARNFDDQR RKKLGDA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [682-1341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKHTRPLISA SLFSTMDDLR ACSVCLYVMT ERSNFARTFR DTFDQLMNAT VGNLIERCGP  60
   61 DSSELIFMAS SVAKRTEPKN INDEANKAIS SGDTLHDSNS ANAANLSNSN DKNISHNGGM 120
  121 PPAVARIFGK GQAEEHAGFV ENSQVDLAEQ EKFKKKQGVL EKTSVPKSLA HLLTKMDDRS 180
  181 RISNSSMSYT TSSSSSSSSS SSSSTLSFPS SQEKNLKINV NNDNNGMTIS SVNREHNNNH 240
  241 NNNNDNNNNN NNNNNNSNNN NNVNNNDNES NSRSTTNNSC NNGNNSQYVR NNNVTMENDV 300
  301 ERPIQDQYIV KKPTNQTEFD WQVFQQQAFL QQQLAQHNLQ AYLSSLNTDT MTNRSPSKSS 360
  361 SISTASSHSD PIPIAMTQSP TPYPQTSNML PQQHVSRPLP QQQREQPQQH ITSPQRFSES 420
  421 NFTNQLNNGM INSNPLQSAI FSNHTSENKQ LRDVEESNFS TSPLRADYGN NIISSIPASF 480
  481 TSNSIPVSVK QARNGSSSGD ILFSNGAHDM INNISTWTNN SVLDALNSKS ILQTIFPQSQ 540
  541 EPSSLSMDKQ QQQHQQQNMC SENNVTANNF QQTQNDPSYN RNLFMMSNQE GVQYNLDETE 600
  601 KNGPKTQVEA NTSANLHFDN VIPTVTNADI RKKRSNWDNM MTSGPVEDFW TINDDYGFLT 660
  661 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [505-732]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNNDSFYTKG VHAAAPSTND HGVQFINQSL KLRRIESQFV ETLQLLKNDS RSVKQSIDQL  60
   61 PLVRKFFEDL EVWRKSYSTL DVKNFENETL KLYYYRSVRL LIQPYLEFFA PEDRLFRECQ 120
  121 AAAGQICQLY KIFHQKTLNG HSTPAVHTVF VAGVTLIYCM WLARNFDDQR RKKLGDASKH 180
  181 TRPLISASLF STMDDLRACS VCLYVMTERS NFARTFRDTF DQLMNATV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [733-1052]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNLIERCGPD SSELIFMASS VAKRTEPKNI NDEANKAISS GDTLHDSNSA NAANLSNSND  60
   61 KNISHNGGMP PAVARIFGKG QAEEHAGFVE NSQVDLAEQE KFKKKQGVLE KTSVPKSLAH 120
  121 LLTKMDDRSR ISNSSMSYTT SSSSSSSSSS SSSTLSFPSS QEKNLKINVN NDNNGMTISS 180
  181 VNREHNNNHN NNNDNNNNNN NNNNNSNNNN NVNNNDNESN SRSTTNNSCN NGNNSQYVRN 240
  241 NNVTMENDVE RPIQDQYIVK KPTNQTEFDW QVFQQQAFLQ QQLAQHNLQA YLSSLNTDTM 300
  301 TNRSPSKSSS ISTASSHSDP 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.26
Match: 1dv4A
Description: 30S subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1053-1249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPIAMTQSPT PYPQTSNMLP QQHVSRPLPQ QQREQPQQHI TSPQRFSESN FTNQLNNGMI  60
   61 NSNPLQSAIF SNHTSENKQL RDVEESNFST SPLRADYGNN IISSIPASFT SNSIPVSVKQ 120
  121 ARNGSSSGDI LFSNGAHDMI NNISTWTNNS VLDALNSKSI LQTIFPQSQE PSSLSMDKQQ 180
  181 QQHQQQNMCS ENNVTAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1r17A
Description: Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1250-1341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFQQTQNDPS YNRNLFMMSN QEGVQYNLDE TEKNGPKTQV EANTSANLHF DNVIPTVTNA  60
   61 DIRKKRSNWD NMMTSGPVED FWTINDDYGF LT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle