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View Structure Prediction Details

Protein: LCB5
Organism: Saccharomyces cerevisiae
Length: 687 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LCB5.

Description E-value Query
Range
Subject
Range
LCB5_YEAST - Sphingoid long chain base kinase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCB5 ...
LCB5 - Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total ac...
0.0 [1..687] [1..687]
Sk1-PA, Sk1-PB - The gene Sphingosine kinase 1 is referred to in FlyBase by the symbol Dmel\Sk1 (CG1747, FBgn0030300)...
gi|220948786 - gi|220948786|gb|ACL86936.1| Sk1-PA [synthetic construct]
3.0E-83 [261..678] [181..641]
DGK1_ARATH - Diacylglycerol kinase 1 OS=Arabidopsis thaliana GN=DGK1 PE=1 SV=2
7.0E-80 [152..586] [224..683]
SPHK2_MOUSE - Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2
3.0E-78 [259..678] [136..613]
gi|119609799, gi... - gi|21361088|ref|NP_068807.2| sphingosine kinase 1 isoform 1 [Homo sapiens], gi|14495625|gb|AAH09419....
4.0E-77 [265..668] [25..371]

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Predicted Domain #1
Region A:
Residues: [1-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLKPSKRRK GRSRHSRKKQ ITSAILTEEG IMIKAKPSSP YTYANRMADK RSRSSIDNIS  60
   61 RTSFQSNISR TSFQSNSDNN SIFETASLIS CVTCLSDTDT IDRSETSTTD TSKDDLSANP 120
  121 KLHYPSVNGQ LPANTVIPYG RILDARYIEK EPLHYYDANS SPSSPLSSSM SNISEKCDLD 180
  181 ELESSQKKER KGNSLSRGSN S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [202-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSLLTSRSP FTKLVEVIFA RPRRHDVVPK RVSLYIDYKP HSSSHLKEED DLVEEILKRS  60
   61 YKNTRRNKSI FVIINPFGGK GKAKKLFMTK AKPLLLASRC SIEVVYTKYP GHAIEIAREM 120
  121 DIDKYDTIAC ASGDGIPHEV INGLYQRPDH VKAFNNIAIT EIPCGSGNAM SVSCHWTNNP 180
  181 SYSTLCLIKS IETRIDLMCC SQPSYAREHP K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 44.60206
Match: PF00781
Description: Diacylglycerol kinase catalytic domain (presumed)

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
kinase activity 0.697281815339077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.541546416312833 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.416174911659548 bayes_pls_golite062009
catalytic activity 0.33446102778142 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [413-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSFLSQTYGL IAETDINTEF IRWMGPARFE LGVAFNIIQK KKYPCEIYVK YAAKSKNELK  60
   61 NHYLEHKNKG SLEFQHITMN KDNEDCDNYN YENEYETENE DEDEDADADD EDSHLISRDL 120
  121 ADSSADQIKE EDFKIKYPLD EGIPSDWERL DPNISNNLGI FYTGKMPYVA ADTKFFPAA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [592-687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPSDGTMDMV ITDARTSLTR MAPILLGLDK GSHVLQPEVL HSKILAYKII PKLGNGLFSV  60
   61 DGEKFPLEPL QVEIMPRLCK TLLRNGRYVD TDFDSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle