YRC Public Data Repository - Protein Structure Prediction

Protein:	FRE1
Organism:	Saccharomyces cerevisiae
Length:	686 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE1.

Description	E-value	Query Range	Subject Range
FRE1_YEAST - Ferric/cupric reductase transmembrane component 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ... gi\|151941055 - gi\|151941055\|gb\|EDN59435.1\| cupric reductase [Saccharomyces cerevisiae YJM789] FRE1 - Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u...	0.0	[1..686]	[1..686]
gi\|68489271, gi\|... - gi\|68489271\|ref\|XP_711522.1\| likely ferric reductase [Candida albicans SC5314], gi\|68489228\|ref\|XP_7... gi\|238881428 - gi\|238881428\|gb\|EEQ45066.1\| conserved hypothetical protein [Candida albicans WO-1] gi\|9963984 - gi\|9963984\|gb\|AAG09788.1\|AF254143_1 repressed by TUP1 protein 2; Rbt2p [Candida albicans]	0.0	[22..686]	[33..706]
RBOHD_ARATH - Respiratory burst oxidase homolog protein D OS=Arabidopsis thaliana GN=RBOHD PE=1 SV=1	0.0	[172..684]	[335..921]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[172..684]	[335..921]
gi\|8131846, gi\|8... - gi\|8131890\|gb\|AAF73124.1\|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi\|8131846...	0.0	[174..684]	[330..938]

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Predicted Domain #1

Region A:
Residues: [1-144]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRTRVLFCL FISFFATVQS SATLISTSCI SQAALYQFGC SSKSKSCYCK NINWLGSVTA  60
   61 CAYENSKSNK TLDSALMKLA SQCSSIKVYT LEDMKNIYLN ASNYLRAPEK SDKKTVVSQP 120
  121 LMANETAYHY YYEENYGIHL NLMR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [145-331]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQWCAWGLVF FWVAVLTAAT ILNILKRVFG KNIMANSVKK SLIYPSVYKD YNERTFYLWK  60
   61 RLPFNFTTRG KGLVVLIFVI LTILSLSFGH NIKLPHPYDR PRWRRSMAFV SRRADLMAIA 120
  121 LFPVVYLFGI RNNPFIPITG LSFSTFNFYH KWSAYVCFML AVVHSIVMTA SGVKRGVFQS 180
  181 LVRKFYF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [332-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RWGIVATILM SIIIFQSEKV FRNRGYEIFL LIHKAMNIMF IIAMYYHCHT LGWMG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [387-516]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WIWSMAGILC FDRFCRIVRI IMNGGLKTAT LSTTDDSNVI KISVKKPKFF KYQVGAFAYM  60
   61 YFLSPKSAWF YSFQSHPFTV LSERHRDPNN PDQLTMYVKA NKGITRVLLS KVLSAPNHTV 120
  121 DCKIFLEGPY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.69897
Match:	1cnf__
Description:	Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.45374095556065	bayes_pls_golite062009
transferase activity	1.15480450573972	bayes_pls_golite062009
binding	1.13408475648113	bayes_pls_golite062009
oxidoreductase activity	0.27336340260908	bayes_pls_golite062009
protein binding	0.144900113694048	bayes_pls_golite062009
cofactor binding	0.0731141170494622	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [517-686]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVTVPHIAKL KRNLVGVAAG LGVAAIYPHF VECLRLPSTD QLQHKFYWIV NDLSHLKWFE  60
   61 NELQWLKEKS CEVSVIYTGS SVEDTNSDES TKGFDDKEES EITVECLNKR PDLKELVRSE 120
  121 IKLSELENNN ITFYSCGPAT FNDDFRNAVV QGIDSSLKID VELEEESFTW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.69897
Match:	1cnf__
Description:	Nitrate reductase core domain; Nitrate reductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: