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View Structure Prediction Details

Protein: PNP1
Organism: Saccharomyces cerevisiae
Length: 311 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNP1.

Description E-value Query
Range
Subject
Range
gi|190405275 - gi|190405275|gb|EDV08542.1| purine nucleoside phosphorylase [Saccharomyces cerevisiae RM11-1a]
gi|207342958 - gi|207342958|gb|EDZ70568.1| YLR209Cp-like protein [Saccharomyces cerevisiae AWRI1631]
PNP1 - Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involve...
PNPH_YEAST - Purine nucleoside phosphorylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNP1 PE=...
gi|151941050 - gi|151941050|gb|EDN59430.1| purine nucleoside phosphorylase [Saccharomyces cerevisiae YJM789]
0.0 [1..311] [1..311]
gi|2624420, gi|1... - gi|2624420|pdb|1VFN| Chain , Purine Nucleoside Phosphorylase, gi|157834116|pdb|1VFN|A Chain A, Pur...
2.0E-95 [37..311] [21..279]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
8.0E-95 [37..311] [24..282]

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Predicted Domain #1
Region A:
Residues: [1-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDILNVSQQ REAITKAAAY ISAILEPHFK NTTNFEPPRT LIICGSGLGG ISTKLSRDNP  60
   61 PPVTVPYQDI PGFKKSTVPG HSGTLMFGSM NGSPVVLMNG RLHGYEGNTL FETTFPIRVL 120
  121 NHMGHVRNLI VTNAAGGINA KYQACDLMCI YDHLNIPGLA GQHPLRGPNL DEDGPRFLAL 180
  181 SDAYDLELRK LLFKKWKELK IQRPLHEGTY TFVSGPTFET RAESKMIRML GGDAVGMSTV 240
  241 PEVIVARHCG WRVLALSLIT NTCVVDSPAS ALDESPVPLE KGKATHAEVL ENGKIASNDV 300
  301 QNLIAAVMGE L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 843.29073
Match: 1vfn__
Description: Purine nucleoside phosphorylase, PNP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
purine-nucleoside phosphorylase activity 3.68206997938506 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 3.66765825367784 bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds 2.28129906270728 bayes_pls_golite062009
catalytic activity 2.18268586151113 bayes_pls_golite062009
transferase activity, transferring pentosyl groups 2.01261001022129 bayes_pls_golite062009
S-methyl-5-thioadenosine phosphorylase activity 1.6959166270803 bayes_pls_golite062009
binding 1.58090357201399 bayes_pls_golite062009
nicotinamide riboside hydrolase activity 1.38986205931368 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 1.38135070025071 bayes_pls_golite062009
protein binding 1.28444435808613 bayes_pls_golite062009
nucleoside binding 1.11256863177576 bayes_pls_golite062009
purine binding 1.00226077276304 bayes_pls_golite062009
nucleobase binding 0.914372836742171 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle