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View Structure Prediction Details

Protein: SWI6
Organism: Saccharomyces cerevisiae
Length: 803 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SWI6.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [5..741] [125..890]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [5..741] [125..890]
gi|178646 - gi|178646|gb|AAA51732.1| ankyrin [Homo sapiens]
 0.0 [5..741] [125..890]
ANK1_MOUSE - (Q02357) Ankyrin-1 (Erythrocyte ankyrin)
 0.0 [5..741] [121..886]

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Predicted Domain #1
Region A:
Residues: [1-201] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEEVVRYL GPHNEIPLTL TRDSETGHFL LKHFLPILQQ YHDTGNINET NPDSFPTDEE  60
   61 RNKLLAHYGI AVNTDDRGEL WIELEKCLQL LNMLNLFGLF QDAFEFEEPE TDQDEEDPSH 120
  121 SKLPENKTKS ENSKDNISSK RINNLQDMSL DSDAHRELGS PLKKLKIDTS VIDAESDSTP 180
  181 NTARGKPNDD INKGPSGDNE N

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [202-511] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGTDDNDRTA GPIITFTHDL TSDFLSSPLK IMKALPSPVV NDNEQKMKLE AFLQRLLFPE  60
   61 IQEMPTSLNN DSSNRNSEGG SSNQQQQHVS FDSLLQEVND AFPNTQLNLN IPVDEHGNTP 120
  121 LHWLTSIANL ELVKHLVKHG SNRLYGDNMG ESCLVKAVKS VNNYDSGTFE ALLDYLYPCL 180
  181 ILEDSMNRTI LHHIIITSGM TGCSAAAKYY LDILMGWIVK KQNRPIQSGT NEKESKPNDK 240
  241 NGERKDSILE NLDLKWIIAN MLNAQDSNGD TCLNIAARLG NISIVDALLD YGADPFIANK 300
  301 SGLRPVDFGA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10043.0
Match: 1sw6A_
Description: Swi6 ankyrin-repeat fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
transcription regulator activity 2.37103377984038 bayes_pls_golite062009
nucleic acid binding 1.8957142857582 bayes_pls_golite062009
DNA binding 1.78305438715057 bayes_pls_golite062009
transcription activator activity 1.6418915400902 bayes_pls_golite062009
transcription factor activity 1.2667825651547 bayes_pls_golite062009
transcription factor binding 1.06366405671195 bayes_pls_golite062009
RNA binding 0.969928411729387 bayes_pls_golite062009
sequence-specific DNA binding 0.949906091645366 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.590503097160372 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.0462605323512499 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [512-600] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSKLQNTNG GDENSKMVSK GDYDGQKNGK AKKIRSQLLK NPPETTSLIN DVQNLLNSIS  60
   61 KDYENETVQY NEKLEKLHKE LNEQREELA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
transcription regulator activity 2.37103377984038 bayes_pls_golite062009
nucleic acid binding 1.8957142857582 bayes_pls_golite062009
DNA binding 1.78305438715057 bayes_pls_golite062009
transcription activator activity 1.6418915400902 bayes_pls_golite062009
transcription factor activity 1.2667825651547 bayes_pls_golite062009
transcription factor binding 1.06366405671195 bayes_pls_golite062009
RNA binding 0.969928411729387 bayes_pls_golite062009
sequence-specific DNA binding 0.949906091645366 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.590503097160372 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.0462605323512499 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [601-803] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSREQLANVK QLKDEYSLMQ EQLTNLKAGI EEEEESFREE SKKLGIIADE SSGIDWDSSE  60
   61 YDADEPFKVE FLSDFLEDKL QKNYEGDISK LLEAESKEQI MEQIRNQLPA EKIQSMLPPT 120
  121 VLLKARINAY KRNDKHLTNV LDTISTKQSE LENKFRRVLS LCLKIDENKV DNMLDGLLQA 180
  181 ISSEDPQDID TDEMQDFLKK HAS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.12
Match: 1f6fA
Description: Prolactin (placental lactogen)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.32153200117175 bayes_pls_golite062009
binding 3.246345109977 bayes_pls_golite062009
receptor binding 2.75738439909781 bayes_pls_golite062009
transcription regulator activity 2.27089567891838 bayes_pls_golite062009
cytokine receptor binding 1.13209989837612 bayes_pls_golite062009
cytokine activity 0.865612008604712 bayes_pls_golite062009
growth factor activity 0.805183150393473 bayes_pls_golite062009
catalytic activity 0.263255675478865 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle