YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: SMC4
Organism: Saccharomyces cerevisiae
Length: 1418 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMC4.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [213..1280] [837..1911]
gi|179508, gi|10... - sp|P12883|MYH7_HUMAN Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta), gi|4557773|ref|NP...
 0.0 [213..1297] [835..1926]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [213..1297] [51..1142]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 0.0 [138..1280] [774..1914]
MYH7_MOUSE - Myosin-7 OS=Mus musculus GN=Myh7 PE=1 SV=1
 0.0 [213..1297] [835..1926]

Back

Predicted Domain #1
Region A:
Residues: [1-135] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSPLSKRQ KRKSAQEPEL SLDQGDAEED SQVENRVNLS ENTPEPDLPA LEASYSKSYT  60
   61 PRKLVLSSGE NRYAFSQPTN STTTSLHVPN LQPPKTSSRG RDHKSYSQSP PRSPGRSPTR 120
  121 RLELLQLSPV KNSRV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.324 0.816 mitotic chromosome condensation c.37.1 P-loop containing nucleoside triphosphate hydrolases

Predicted Domain #2
Region A:
Residues: [136-213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELQKIYDRHQ SSSKQQSRLF INELVLENFK SYAGKQVVGP FHTSFSAVVG PNGSGKSNVI  60
   61 DSMLFVFGFR ANKMRQDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1ii8A_
Description: Rad50
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [214-511] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSDLIHKSEA FPSLQSCSVA VHFQYVIDES SGTSRIDEEK PGLIITRKAF KNNSSKYYIN  60
   61 EKESSYTEVT KLLKNEGIDL DHKRFLILQG EVENIAQMKP KAEKESDDGL LEYLEDIIGT 120
  121 ANYKPLIEER MGQIENLNEV CLEKENRFEI VDREKNSLES GKETALEFLE KEKQLTLLRS 180
  181 KLFQFKLLQS NSKLASTLEK ISSSNKDLED EKMKFQESLK KVDEIKAQRK EIKDRISSCS 240
  241 SKEKTLVLER RELEGTRVSL EERTKNLVSK MEKAEKTLKS TKHSISEAEN MLEELRGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.045757
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [512-655] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTEHETEIKD LTQLLEKERS ILDDIKLSLK DKTKNISAEI IRHEKELEPW DLQLQEKESQ  60
   61 IQLAESELSL LEETQAKLKK NVETLEEKIL AKKTHKQELQ DLILDLKKKL NSLKDERSQG 120
  121 EKNFTSAHLK LKEMQKVLNA HRQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.0
Match: 1cii__
Description: Colicin Ia; Colicin Ia, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [656-691] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AMEARSSLSK AQNKSKVLTA LSRLQKSGRI NGFHGR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [714-746] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDVVVDTVEC AQHCIDYLRK NKLGYARFIL LDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1gxlA_
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.87197012801422 bayes_pls_golite062009
protein binding 1.11054097120015 bayes_pls_golite062009
protein heterodimerization activity 0.87613701344509 bayes_pls_golite062009
structure-specific DNA binding 0.655291890141256 bayes_pls_golite062009
DNA secondary structure binding 0.597643104953011 bayes_pls_golite062009
protein dimerization activity 0.423916142680929 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.340360347691162 bayes_pls_golite062009
pyrophosphatase activity 0.287295057420232 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.273916899375488 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.271570433187831 bayes_pls_golite062009
ATPase activity 0.142237490738159 bayes_pls_golite062009
DNA binding 0.0749274471142563 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [692-713] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGDLGVIDDS FDVAISTACP RL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [747-750] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRQF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [766-784] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLVKPKNPKF SNAFYSVLR

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [828-854] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAKGLMKLGT NQSDKVDDYT PEEVDKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1gxlA_
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [751-765] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLQPISTPEN VPRLF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [785-827] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTLVAQNLKQ ANNVAYGKKR FRVVTVDGKL IDISGTMSGG GNH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1gxlA_
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [855-918] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERELSERENN FRVASDTVHE MEEELKKLRD HEPDLESQIS KAEMEADSLA SELTLAEQQV  60
   61 KEAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.221849
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [919-1131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYVKAVSDK AQLNVVMKNL ERLRGEYNDL QSETKTKKEK IKGLQDEIMK IGGIKLQMQN  60
   61 SKVESVCQKL DILVAKLKKV KSASKKSGGD VVKFQKLLQN SERDVELSSD ELKVIEEQLK 120
  121 HTKLALAEND TNMNETLNLK VELKEQSEQL KEQMEDMEES INEFKSIEIE MKNKLEKLNS 180
  181 LLTYIKSEIT QQEKGLNELS IRDVTHTLGM LDD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.221849
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1132-1219] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKMDSVKEDV KNNQELDQEY RSCETQDESE IKDAETSCDN YHPMNIDETS DEVSRGIPRL  60
   61 SEDELRELDV ELIESKINEL SYYVEETN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1jchA_
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #11
Region A:
Residues: [1220-1418] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDIGVLEEYA RRLAEFKRRK LDLNNAVQKR DEVKEQLGIL KKKRFDEFMA GFNIISMTLK  60
   61 EMYQMITMGG NAELELVDSL DPFSEGVTFS VMPPKKSWRN ITNLSGGEKT LSSLALVFAL 120
  121 HKYKPTPLYV MDEIDAALDF RNVSIVANYI KERTKNAQFI VISLRNNMFE LAQQLVGVYK 180
  181 RDNRTKSTTI KNIDILNRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 170.751666
Match: 1e69A_
Description: Smc head domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle