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View Structure Prediction Details

Protein: PET309
Organism: Saccharomyces cerevisiae
Length: 965 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PET309.

Description E-value Query
Range
Subject
Range
gi|15221621 - gi|15221621|ref|NP_176479.1| pentatricopeptide (PPR) repeat-containing protein [Arabidopsis thaliana...
0.0 [56..956] [53..927]

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Predicted Domain #1
Region A:
Residues: [1-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRCAPAVLR NYNYKKGIWS TGVPDHIRKL LRDKSTSPLC SQDERNLVSY FMARGSVPLK  60
   61 SVGSGLTKKA TTSITSNSAT TTFERQYLIK YLYRHQAYGN VIKIAQKFLY TTIGSQRLLK 120
  121 QDASLPELKK FLLSLLILQR GIQLDQAISD IIQRFLLTQK TMVIDLINSI FSRMVIMNMH 180
  181 EEAVYKWVKW MKLVNGHCEF TNYMENKIVL RNFLSFMRQS NVRPDYLSYL KAIQLTQGPA 240
  241 IASQFATTLL FLLTYIRKFS SAEAVWNYKC EHNLPIVSSD LTCILKTYCH MQKFNLVSST 300
  301 YWKYPDAQHD QNQFDYLLVA HSRLHNWDAL QQQFNALFGI GKLPSIQHYG ILMYTMARIG 360
  361 ELDSVNKLYT QLLRRGMIPT YAVLQSLLYA HYKVGDFAAC FSHFELFKKY DITPSTATHT 420
  421 IMLKVYRGLN DLDGAFRILK RLSEDPSVEI TEGHFALLIQ MCCKTTNHLI AQELFNLMTE 480
  481 HYNIQHTGKS ISALMDVYIE SNRPTEAIAL FEKHSKNLSW RDGLISVYNK AIKAYIGLRN 540
  541 ANKCEELFDK ITTSKLAVNS EFYKMMIKFL VTLNEDCETA LSIIDQLIKH SVIKVDATHF 600
  601 EIIMEAYDKE GYRDGIINLY KTMSQNKVPA NSKILYYILK AVAKKSLQNN EEIKETINMV 660
  661 EDIMENAANG TLDVTYNKLH PSVMAWPMRM IV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [693-824]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHDSPQRALE LYNRYNELFF KKHDWISNNN KFVMMRSLLV LLAQIEQWKD FETLFAKYMD  60
   61 RIENIENLPS STTPNIKLRS IFSGLFPYKV SQLIAMNKID ELPLLWKKLR EKGFILDNIS 120
  121 WNSAVEALFK DP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.874 0.055 aerobic respiration a.118.8 TPR-like
View Download 0.459 0.021 aerobic respiration a.74.1 Cyclin-like
View Download 0.838 0.004 aerobic respiration a.7.6 Ribosomal protein S20
View Download 0.510 0.002 aerobic respiration a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.453 0.002 aerobic respiration a.46.1 Methionine synthase domain
View Download 0.440 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.419 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.401 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.392 N/A N/A a.126.1 Serum albumin-like
View Download 0.378 N/A N/A a.1.1 Globin-like
View Download 0.371 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.368 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.325 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.319 N/A N/A a.29.2 Bromodomain
View Download 0.316 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.314 N/A N/A a.7.8 GAT domain
View Download 0.295 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.294 N/A N/A a.74.1 Cyclin-like
View Download 0.290 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.286 N/A N/A a.74.1 Cyclin-like
View Download 0.270 N/A N/A a.74.1 Cyclin-like
View Download 0.266 N/A N/A a.63.1 Apolipophorin-III
View Download 0.264 N/A N/A a.118.8 TPR-like
View Download 0.264 N/A N/A a.118.8 TPR-like
View Download 0.259 N/A N/A i.1.1 Ribosome and ribosomal fragments
View Download 0.257 N/A N/A a.1.1 Globin-like
View Download 0.254 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.252 N/A N/A g.36.1 Ferredoxin thioredoxin reductase (FTR), catalytic beta chain
View Download 0.251 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.249 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.249 N/A N/A a.24.12 Outer surface protein C (OspC)
View Download 0.245 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.223 N/A N/A a.118.8 TPR-like
View Download 0.219 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.213 N/A N/A a.118.8 TPR-like
View Download 0.210 N/A N/A a.74.1 Cyclin-like
View Download 0.209 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.207 N/A N/A a.160.1 Poly(A) polymerase, middle domain
View Download 0.206 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.205 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.203 N/A N/A a.26.1 4-helical cytokines
View Download 0.202 N/A N/A a.160.1 Poly(A) polymerase, middle domain
View Download 0.201 N/A N/A a.48.1 N-terminal domain of cbl (N-cbl)

Predicted Domain #3
Region A:
Residues: [825-965]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTLSYGMKIV DDTLIHGYNL IHKFRLLTKL SEDKTQSSDK SWPTLKMKEK EPNKFQPRLY  60
   61 LKSDTYNSIM RQLDTYLDGI DDLKTLEDQV RDFISNYKYF MKDYLLMPRS KINKWEQIEM 120
  121 RHLSYFKELR KSKRVLPVSK F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.600 0.110 aerobic respiration a.133.1 Phospholipase A2, PLA2
View Download 0.494 0.039 RNA metabolic process a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.491 0.018 aerobic respiration a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.609 0.017 aerobic respiration a.47.2 t-snare proteins
View Download 0.560 0.005 aerobic respiration a.63.1 Apolipophorin-III
View Download 0.474 N/A N/A a.7.8 GAT domain
View Download 0.449 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.429 N/A N/A a.24.4 Hemerythrin
View Download 0.394 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.345 N/A N/A d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.322 N/A N/A a.89.1 Methyl-coenzyme M reductase alpha and beta chain C-terminal domain
View Download 0.322 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.304 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.287 N/A N/A a.1.1 Globin-like
View Download 0.287 N/A N/A a.24.1 Apolipoprotein
View Download 0.254 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.248 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.246 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.234 N/A N/A a.7.4 Smac/diablo
View Download 0.233 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.216 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.215 N/A N/A a.1.1 Globin-like
View Download 0.212 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.210 N/A N/A a.25.1 Ferritin-like
View Download 0.210 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.206 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.203 N/A N/A a.29.2 Bromodomain
View Download 0.202 N/A N/A c.65.1 Formyltransferase

Predicted Domain #4
Region A:
Residues: [274-626]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPIVSSDLTC ILKTYCHMQK FNLVSSTYWK YPDAQHDQNQ FDYLLVAHSR LHNWDALQQQ  60
   61 FNALFGIGKL PSIQHYGILM YTMARIGELD SVNKLYTQLL RRGMIPTYAV LQSLLYAHYK 120
  121 VGDFAACFSH FELFKKYDIT PSTATHTIML KVYRGLNDLD GAFRILKRLS EDPSVEITEG 180
  181 HFALLIQMCC KTTNHLIAQE LFNLMTEHYN IQHTGKSISA LMDVYIESNR PTEAIALFEK 240
  241 HSKNLSWRDG LISVYNKAIK AYIGLRNANK CEELFDKITT SKLAVNSEFY KMMIKFLVTL 300
  301 NEDCETALSI IDQLIKHSVI KVDATHFEII MEAYDKEGYR DGIINLYKTM SQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.154902
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.67835748923436 bayes_pls_golite062009
binding 2.29041171814244 bayes_pls_golite062009
transcription regulator activity 1.36301889945421 bayes_pls_golite062009
nucleic acid binding 1.04482640570705 bayes_pls_golite062009
DNA binding 1.03582297487751 bayes_pls_golite062009
oxidoreductase activity 0.967526235944614 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.853542267130676 bayes_pls_golite062009
signal transducer activity 0.730941324269551 bayes_pls_golite062009
molecular transducer activity 0.730941324269551 bayes_pls_golite062009
transcription activator activity 0.628603889499786 bayes_pls_golite062009
receptor activity 0.393899879588134 bayes_pls_golite062009
transcription factor activity 0.39224150319016 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [627-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVPANSKILY YILKAVAKKS LQNNEEIKET INMVEDIMEN AANGTLDVTY NKLHPSVMAW  60
   61 PMRMIVKHDS PQRALELYNR YNELFFKKHD WISNNNKFVM MRSLLVLLAQ IEQWKDFETL 120
  121 FAKYMDRIEN IENLPSSTTP NIKLRSIFSG LFPYKVSQLI AMNKIDELPL LWKKLREKGF 180
  181 I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.874 a.118.8 TPR-like
View Download 0.838 a.7.6 Ribosomal protein S20
View Download 0.510 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.459 a.74.1 Cyclin-like
View Download 0.453 a.46.1 Methionine synthase domain

Predicted Domain #6
Region A:
Residues: [808-965]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDNISWNSAV EALFKDPRTL SYGMKIVDDT LIHGYNLIHK FRLLTKLSED KTQSSDKSWP  60
   61 TLKMKEKEPN KFQPRLYLKS DTYNSIMRQL DTYLDGIDDL KTLEDQVRDF ISNYKYFMKD 120
  121 YLLMPRSKIN KWEQIEMRHL SYFKELRKSK RVLPVSKF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.609 N/A N/A a.47.2 t-snare proteins
View Download 0.600 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.560 N/A N/A a.63.1 Apolipophorin-III
View Download 0.494 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.491 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle