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View Structure Prediction Details

Protein: HIF1
Organism: Saccharomyces cerevisiae
Length: 385 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIF1.

Description E-value Query
Range
Subject
Range
HIF1 - Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localize...
HIF1_YEAST - HAT1-interacting factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIF1 PE=1 SV=1
0.0 [1..385] [1..385]

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Predicted Domain #1
Region A:
Residues: [1-385]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLRAEDVLA NGTSRHKVQI DMERQVQIAK DLLAQKKFLE AAKRCQQTLD SLPKDGLLPD  60
   61 PELFTIFAQA VYNMEVQNSG NLFGDALLAG DDGSGSESES EPESDVSNGE EGNENGQTEI 120
  121 PNSRMFQFDQ EEEDLTGDVD SGDSEDSGEG SEEEEENVEK EEERLALHEL ANFSPANEHD 180
  181 DEIEDVSQLR KSGFHIYFEN DLYENALDLL AQALMLLGRP TADGQSLTEN SRLRIGDVYI 240
  241 LMGDIEREAE MFSRAIHHYL KALGYYKTLK PAEQVTEKVI QAEFLVCDAL RWVDQVPAKD 300
  301 KLKRFKHAKA LLEKHMTTRP KDSELQQARL AQIQDDIDEV QENQQHGSKR PLSQPTTSIG 360
  361 FPALEKPLGD FNDLSQLVKK KPRRH

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.63
Match: 1gt8A
Description: Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
N-acetyltransferase activity 4.5018555446719 bayes_pls_golite062009
N-acyltransferase activity 4.22651890245436 bayes_pls_golite062009
acetyltransferase activity 3.92209893972978 bayes_pls_golite062009
acyltransferase activity 3.39383036142893 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.35794141017853 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.18633096034095 bayes_pls_golite062009
binding 2.64850159998065 bayes_pls_golite062009
transcription regulator activity 2.36976362065221 bayes_pls_golite062009
nucleic acid binding 2.05265117445838 bayes_pls_golite062009
DNA binding 1.96740629247708 bayes_pls_golite062009
protein binding 1.51322932625387 bayes_pls_golite062009
transcription repressor activity 1.40841220242471 bayes_pls_golite062009
transcription factor activity 1.22524361832616 bayes_pls_golite062009
transcription factor binding 0.447234745044969 bayes_pls_golite062009
transcription cofactor activity 0.201108481303385 bayes_pls_golite062009
ligase activity 0.185046836723848 bayes_pls_golite062009
transcription coactivator activity 0.0645101607447045 bayes_pls_golite062009
transcription activator activity 0.0514451541233234 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle