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View Structure Prediction Details

Protein: TRZ1
Organism: Saccharomyces cerevisiae
Length: 838 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRZ1.

Description E-value Query
Range
Subject
Range
RNZ_YEAST - Ribonuclease Z OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRZ1 PE=1 SV=1
TRZ1 - tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetical...
0.0 [1..838] [1..838]
gi|22330184, gi|... - gi|22330184|ref|NP_175628.2| TRZ3 (TRNASE Z 3); 3'-tRNA processing endoribonuclease/ catalytic [Arab...
0.0 [4..831] [106..888]
gi|148678451, gi... - gi|148678451|gb|EDL10398.1| elaC homolog 2 (E. coli), isoform CRA_a [Mus musculus], gi|13540342|gb|A...
0.0 [4..826] [51..784]
gi|48146639, gi|... - gi|48146639|emb|CAG33542.1| ELAC2 [Homo sapiens], gi|21359941|ref|NP_060597.3| elaC homolog 2 [Homo ...
0.0 [4..813] [59..775]
RNZ2_GORGO - Zinc phosphodiesterase ELAC protein 2 OS=Gorilla gorilla gorilla GN=ELAC2 PE=2 SV=1
gi|10946489 - gi|10946489|gb|AAG24916.1|AF308694_1 ELAC2 [Gorilla gorilla]
0.0 [4..813] [59..775]
RNZ2_PANTR - Zinc phosphodiesterase ELAC protein 2 OS=Pan troglodytes GN=ELAC2 PE=2 SV=1
0.0 [4..813] [59..775]

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Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTFIPITHP TSDTKHPLLL VQSAHGEKYF FGKIGEGSQR SLTENKIRIS KLKDIFLTGE  60
   61 LNWSDIGGLP GMILTIADQG KSNLVLHYGN DILNYIVSTW RYFVFRFGID LNDHIMKDKE 120
  121 VYKDKIIAVK SFNVLKNGGE DRLGVFDSFQ KGVLRSIVAK MFPKHAPTDR YDPSSDPHLN 180
  181 VELPDLDAKV EVSTNYEISF SPVR

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.66
Match: 1qh5A
Description: Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.25638799652541 bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity 0.998280249151351 bayes_pls_golite062009
nucleic acid binding 0.980281910076056 bayes_pls_golite062009
catalytic activity 0.941400907161877 bayes_pls_golite062009
RNA binding 0.794779546418275 bayes_pls_golite062009
protein binding 0.0732519352239051 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [205-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKFKVEEAIK LGVPKGPLFA KLTKGQTITL DNGIVVTPEQ VLENERHFAK VLILDIPDDL  60
   61 YLNAFVEKFK DYDCAELGMV YYFLGDEVTI NDNLFAFIDI FEKN

[Run NCBI BLAST on this sequence.]

Detection Method: Pcons
Confidence: 1.66
Match: 1qh5A
Description: Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.31163219351982 bayes_pls_golite062009
nucleic acid binding 0.995499818152009 bayes_pls_golite062009
catalytic activity 0.888964130802536 bayes_pls_golite062009
RNA binding 0.752641444664237 bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity 0.6076643116915 bayes_pls_golite062009
protein binding 0.104060533429009 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [309-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYGKVNHMIS HNKISPNTIS FFGSALTTLK LKALQVNNYN LPKTDRVFSK DFYDRFDTPL  60
   61 SRGTSMCKSQ EEPLNTIIEK DNIHIFSQNK TVTFEPFRMN EEPMKCNING EVADFSWQEI 120
  121 FEEHVKPLEF PLADVDTVIN NQLHVDNF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.595 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.339 a.4.5 "Winged helix" DNA-binding domain
View Download 0.725 d.82.2 Frataxin-like
View Download 0.481 a.74.1 Cyclin-like
View Download 0.321 b.60.1 Lipocalins
View Download 0.489 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.418 a.19.1 Fertilization protein
View Download 0.506 a.167.1 Porin chaperone SurA, peptide-binding domain
View Download 0.352 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.408 a.1.1 Globin-like
View Download 0.399 a.182.1 GatB/YqeY domain
View Download 0.397 a.66.1 Transducin (alpha subunit), insertion domain
View Download 0.370 a.1.1 Globin-like
View Download 0.368 d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.342 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.320 d.19.1 MHC antigen-recognition domain
View Download 0.316 a.4.5 "Winged helix" DNA-binding domain
View Download 0.314 a.74.1 Cyclin-like
View Download 0.307 a.126.1 Serum albumin-like
View Download 0.297 d.19.1 MHC antigen-recognition domain
View Download 0.295 c.52.3 Eukaryotic RPB5 N-terminal domain
View Download 0.286 d.92.1 Metalloproteases ("zincins"), catalytic domain
View Download 0.285 b.60.1 Lipocalins
View Download 0.282 d.2.1 Lysozyme-like
View Download 0.272 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.272 a.24.11 Bacterial GAP domain
View Download 0.271 a.19.1 Fertilization protein
View Download 0.269 b.60.1 Lipocalins
View Download 0.263 a.5.4 Elongation factor TFIIS domain 2
View Download 0.257 c.26.1 Nucleotidylyl transferase
View Download 0.250 a.22.1 Histone-fold
View Download 0.244 i.11.1 Computational models partly based on NMR data
View Download 0.230 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.224 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.217 c.56.3 Peptidyl-tRNA hydrolase
View Download 0.216 a.7.5 Tubulin chaperone cofactor A
View Download 0.206 a.133.1 Phospholipase A2, PLA2
View Download 0.203 a.126.1 Serum albumin-like
View Download 0.203 b.88.1 Mss4-like

Predicted Domain #4
Region A:
Residues: [457-639]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSAEKKKHV EIITLGTGSA LPSKYRNVVS TLVKVPFTDA DGNTINRNIM LDAGENTLGT  60
   61 IHRMFSQLAV KSIFQDLKMI YLSHLHADHH LGIISVLNEW YKYNKDDETS YIYVVTPWQY 120
  121 HKFVNEWLVL ENKEILKRIK YISCEHFIND SFVRMQTQSV PLAEFNEILK ENSNQESNRK 180
  181 LEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1e5dA_
Description: Rubredoxin oxygen:oxidoreductase (ROO), C-terminal domain; Rubredoxin oxygen:oxidoreductase (ROO), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.25638799652541 bayes_pls_golite062009
3'-tRNA processing endoribonuclease activity 0.998280249151351 bayes_pls_golite062009
nucleic acid binding 0.980281910076056 bayes_pls_golite062009
catalytic activity 0.941400907161877 bayes_pls_golite062009
RNA binding 0.794779546418275 bayes_pls_golite062009
protein binding 0.0732519352239051 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [640-838]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRDSSYRDVD LIRQMYEDLS IEYFQTCRAI HCDWAYSNSI TFRMDENNEH NTFKVSYSGD  60
   61 TRPNIEKFSL EIGYNSDLLI HEATLENQLL EDAVKKKHCT INEAIGVSNK MNARKLILTH 120
  121 FSQRYPKLPQ LDNNIDVMAR EFCFAFDSMI VDYEKIGEQQ RIFPLLNKAF VEEKEEEEDV 180
  181 DDVESVQDLE VKLKKHKKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle