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View Structure Prediction Details

Protein: MNN4
Organism: Saccharomyces cerevisiae
Length: 1178 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MNN4.

Description E-value Query
Range
Subject
Range
gi|2980815 - gi|2980815|emb|CAA82044.1| MNN4 [Saccharomyces cerevisiae]
541.0 [0..1] [639..1]
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
495.0 [0..162] [1177..1865]
gi|28564137 - gi|28564137|gb|AAO32447.1| MNN4 [Saccharomyces bayanus]
458.0 [0..1] [744..1]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
384.0 [0..202] [1178..937]
MYH1_BOVIN - Myosin-1 OS=Bos taurus GN=MYH1 PE=2 SV=2
384.0 [0..202] [1178..938]
gi|50757621 - gi|50757621|ref|XP_415581.1| PREDICTED: similar to fast myosin heavy chain isoform 3 [Gallus gallus]
382.0 [0..202] [1178..1040]

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Predicted Domain #1
Region A:
Residues: [1-164]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR NGLGRDADYL  60
   61 LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF GTNPKWVNEY TLQNDLLSVK 120
  121 MGPRKGSKLE SVDELKFYDF DPRLTWSVVL NHLQNNDADQ PEKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.293 N/A N/A d.379.1 Description not found.
View Download 0.256 N/A N/A a.118.8 TPR-like
View Download 0.256 N/A N/A a.118.8 TPR-like
View Download 0.248 N/A N/A a.118.8 TPR-like
View Download 0.247 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.247 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.228 N/A N/A a.25.1 Ferritin-like
View Download 0.211 N/A N/A c.23.5 Flavoproteins
View Download 0.210 N/A N/A a.25.1 Ferritin-like

Predicted Domain #2
Region A:
Residues: [165-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFSWYDWTTF HELNKLISID KTVLPCNFLF QSAFDKESLE AIETELGEPL FLYERPKYAQ  60
   61 KLWYKAARNQ DRIKDSKELK KHCSKLFTPD GHG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.602 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.559 a.22.1 Histone-fold
View Download 0.519 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.519 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.511 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.504 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.486 c.5.1 MurCD N-terminal domain
View Download 0.457 a.4.5 "Winged helix" DNA-binding domain
View Download 0.446 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.437 c.5.1 MurCD N-terminal domain

Predicted Domain #3
Region A:
Residues: [258-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKGLRFNTQ FQIKELYDKV RPEVYQLQAR NYILTTQSHP LSISIIESDN STYQVPLQTE  60
   61 KSKNLVQSGL LQEYINDNIN STNKRKKNKQ DVEFNHNRLF QEFVNNDQVN SLYKLEIEET 120
  121 DKFTFDKDLV YLSPSDFKFD ASKKIEELEE QKKLYPDKFS AHNENYLNSL KNSVKTSPAL 180
  181 QRKFFYEAGA VKQYKGMGFH RDKRFFNVDT LINDKQEYQA RLNSMIRTFQ KFTKANGIIS 240
  241 WLSHGTLYGY LYNGMAFPWD NDFDLQMPIK HLQLLSQYFN QSLILEDPRQ GNGRYFLDVS 300
  301 DSLTVRINGN GKNNIDARFI DVDTGLYIDI TGLASTSAPS RDYLNSYIEE RLQEEHLDIN 360
  361 NIPESNGETA TLPDKVDDGL VNMATLNITE LRDYITSDEN KNHKRVPTDT DLKDLLKKEL 420
  421 EELPKSKTIE NK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [690-1122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNPKQRYFLN EKLKLYNCRN NHFNSFEELS PLINTVFHGV PALIPHRHTY CLHNEYHVPD  60
   61 RYAFDAYKNT AYLPEFRFWF DYDGLKKCSN INSWYPNIPS INSWNPNLLK EISSTKFESK 120
  121 LFDSNKVSEY SFKNLSMDDV RLIYKNIPKA GFIEVFTNLY NSFNVTAYRQ KELEIQYCQN 180
  181 LTFIEKKKLL HQLRINVAPK LSSPAKDPFL FGYEKAMWKD LSKSMNQTTL DQVTKIVHEE 240
  241 YVGKIIDLSE SLKYRNFSLF NITFDETGTT LDDNTEDYTP ANTVEVNPVD FKSNLNFSSN 300
  301 SFLDLNSYGL DLFAPTLSDV NRKGIQMFDK DPIIVYEDYA YAKLLEERKR REKKKKEEEE 360
  361 KKKKEEEEKK KKEEEEKKKK EEEEKKKKEE EEKKKKEEEE KKKQEEEEKK KKEEEEKKKQ 420
  421 EEGEKMKNED EEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.39794
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1123-1178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKNEDEEKKK NEEEEKKKQE EKNKKNEDEE KKKQEEEEKK KNEEEEKKKQ EEGHSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.562 a.60.1 SAM/Pointed domain
View Download 0.562 a.60.1 SAM/Pointed domain
View Download 0.501 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.492 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.492 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.491 a.4.1 Homeodomain-like
View Download 0.480 a.4.1 Homeodomain-like
View Download 0.385 a.4.1 Homeodomain-like
View Download 0.383 a.4.1 Homeodomain-like
View Download 0.361 a.4.1 Homeodomain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle