YRC Public Data Repository - Protein Structure Prediction

Protein:	YKT6
Organism:	Saccharomyces cerevisiae
Length:	200 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YKT6.

Description	E-value	Query Range	Subject Range
YKT6 - Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and wit... gi\|151941723 - gi\|151941723\|gb\|EDN60084.1\| v-SNARE [Saccharomyces cerevisiae YJM789] gi\|190409647 - gi\|190409647\|gb\|EDV12912.1\| hypothetical protein SCRG_03832 [Saccharomyces cerevisiae RM11-1a] ORFP:14223 - YKL196C, Contig c319 75707-76309 gi\|207343688 - gi\|207343688\|gb\|EDZ71077.1\| YKL196Cp-like protein [Saccharomyces cerevisiae AWRI1631] YKT6_YEAST - Synaptobrevin homolog YKT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YKT6 PE=1 SV=...	8.0E-65	[1..200]	[1..200]
gi\|25349719, gi\|... - gi\|3859707\|emb\|CAA21982.1\| probable snare protein [Candida albicans], pir\|\|T52162 probable snare pro... gi\|68469373, gi\|... - gi\|68469373\|ref\|XP_721201.1\| hypothetical protein CaO19.10491 [Candida albicans SC5314], gi\|68468829... gi\|238879237 - gi\|238879237\|gb\|EEQ42875.1\| hypothetical protein CAWG_01098 [Candida albicans WO-1]	3.0E-62	[1..200]	[1..200]
gi\|4097579 - gi\|4097579\|gb\|AAD00116.1\| NTGP1 [Nicotiana tabacum]	5.0E-61	[1..200]	[1..199]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-59	[1..200]	[1..198]
gi\|109066683 - gi\|109066683\|ref\|XP_001092567.1\| PREDICTED: similar to YKT6 v-SNARE protein isoform 2 [Macaca mulatt... CCDS5482.1_1 - null gi\|123994315, gi... - gi\|60655967\|gb\|AAX32547.1\| SNARE protein Ykt6 [synthetic construct], gi\|60655965\|gb\|AAX32546.1\| SNAR... YKT6 - YKT6 v-SNARE homolog (S. cerevisiae) gi\|114613119 - gi\|114613119\|ref\|XP_001144106.1\| PREDICTED: YKT6 v-SNARE protein isoform 3 [Pan troglodytes]	1.0E-58	[1..200]	[1..198]
YKT61_ARATH - VAMP-like protein YKT61 OS=Arabidopsis thaliana GN=YKT61 PE=2 SV=1	7.0E-58	[1..200]	[1..199]
YKT6_MOUSE - Synaptobrevin homolog YKT6 OS=Mus musculus GN=Ykt6 PE=1 SV=1	8.0E-58	[1..200]	[1..198]
ykt6 - SNARE Ykt6 YKT6_SCHPO - Synaptobrevin homolog ykt6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ykt6 PE=3 SV=1	2.0E-56	[1..199]	[1..196]
Ykt6-PA - This gene is referred to in FlyBase by the symbol Dmel\Ykt6 (CG1515, FBgn0260858). It is a protein_c... gi\|194203791, gi... - gi\|195565657\|ref\|XP_002106415.1\| GD16871 [Drosophila simulans], gi\|194203791\|gb\|EDX17367.1\| GD16871 ... gi\|220955826, gi... - gi\|220955826\|gb\|ACL90456.1\| l(1)G0155-PA [synthetic construct], gi\|220946098\|gb\|ACL85592.1\| l(1)G015... gi\|195355986, gi... - gi\|195355986\|ref\|XP_002044464.1\| GM11984 [Drosophila sechellia], gi\|194131629\|gb\|EDW53671.1\| GM11984... gi\|194188740, gi... - gi\|195480300\|ref\|XP_002101216.1\| GE15747 [Drosophila yakuba], gi\|194188740\|gb\|EDX02324.1\| GE15747 [D... gi\|190650236, gi... - gi\|194897084\|ref\|XP_001978587.1\| GG19670 [Drosophila erecta], gi\|190650236\|gb\|EDV47514.1\| GG19670 [D...	3.0E-56	[1..197]	[2..196]

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Predicted Domain #1

Region A:
Residues: [1-137]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIYYIGVFR SGGEKALELS EVKDLSQFGF FERSSVGQFM TFFAETVASR TGAGQRQSIE  60
   61 EGNYIGHVYA RSEGICGVLI TDKEYPVRPA YTLLNKILDE YLVAHPKEEW ADVTETNDAL 120
  121 KMKQLDTYIS KYQDPSQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	798.68867
Match:	1h8mA_
Description:	Synaptobrevin homolog 1 ykt6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-cysteine S-acyltransferase activity	5.70902768432932	bayes_pls_golite062009
protein-cysteine S-palmitoleyltransferase activity	5.70902768432932	bayes_pls_golite062009
S-acyltransferase activity	2.42277624456482	bayes_pls_golite062009
palmitoyltransferase activity	2.39665981402803	bayes_pls_golite062009
SNAP receptor activity	2.23518960752054	bayes_pls_golite062009
clathrin binding	2.03985651011974	bayes_pls_golite062009
binding	1.76450203501026	bayes_pls_golite062009
transporter activity	1.71943098913274	bayes_pls_golite062009
substrate-specific transporter activity	0.939682472116899	bayes_pls_golite062009
hydrolase activity	0.815544630085919	bayes_pls_golite062009
signal recognition particle binding	0.66489873553532	bayes_pls_golite062009
protein binding	0.590936503990514	bayes_pls_golite062009
protein transporter activity	0.17469233791907	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.131410992694836	bayes_pls_golite062009
pyrophosphatase activity	0.0936690070284361	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0846345824909659	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0820309452260982	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [138-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADAIMKVQQE LDETKIVLHK TIENVLQRGE KLDNLVDKSE SLTASSKMFY KQAKKSNSCC  60
   61 IIM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.9897
Match:	1gl2A_
Description:	Endobrevin
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: